ENSG00000112624

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314073 ENSG00000112624 HEK293_OSMI2_2hA HEK293_TMG_2hB BICRAL protein_coding protein_coding 1.637704 1.106011 2.043046 0.07673082 0.02758659 0.8794148 0.4013260 0.07573812 0.1241218 0.07573812 0.12412180 0.6455350 0.2531417 0.0603 0.05916667 -0.001133333 9.430925e-01 7.191343e-05 FALSE TRUE
MSTRG.28300.1 ENSG00000112624 HEK293_OSMI2_2hA HEK293_TMG_2hB BICRAL protein_coding   1.637704 1.106011 2.043046 0.07673082 0.02758659 0.8794148 0.2113565 0.00000000 0.4904522 0.00000000 0.10037762 5.6451602 0.1095667 0.0000 0.24146667 0.241466667 7.191343e-05 7.191343e-05 FALSE TRUE
MSTRG.28300.3 ENSG00000112624 HEK293_OSMI2_2hA HEK293_TMG_2hB BICRAL protein_coding   1.637704 1.106011 2.043046 0.07673082 0.02758659 0.8794148 0.9768707 1.03027268 1.4284718 0.01687548 0.02458915 0.4675752 0.6129792 0.9397 0.69936667 -0.240333333 8.566435e-02 7.191343e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112624 E001 0.5848434 0.0208265613 1.351572e-01 0.2413119311 6 42746328 42746362 35 + 0.248 0.000 -12.296
ENSG00000112624 E002 0.3299976 0.0274424043 7.867586e-02   6 42746958 42747023 66 + 0.000 0.322 14.038
ENSG00000112624 E003 1.2125613 0.0123928684 1.567213e-01 0.2707293593 6 42781839 42781927 89 + 0.371 0.190 -1.298
ENSG00000112624 E004 0.8921407 0.0138423343 4.751604e-02 0.1047594623 6 42781928 42781984 57 + 0.334 0.000 -12.881
ENSG00000112624 E005 0.4502799 0.0363999914 2.377546e-01 0.3715470352 6 42781985 42782031 47 + 0.198 0.000 -11.882
ENSG00000112624 E006 0.7427016 0.0157311986 7.896039e-02 0.1578550765 6 42782032 42782051 20 + 0.293 0.000 -12.618
ENSG00000112624 E007 2.5873609 0.0059796995 3.123778e-02 0.0743632800 6 42782052 42782101 50 + 0.590 0.322 -1.397
ENSG00000112624 E008 0.6902858 0.3532294998 2.419730e-01 0.3765178871 6 42783800 42783827 28 + 0.076 0.425 3.110
ENSG00000112624 E009 1.2190178 0.0111753464 1.556895e-01 0.2693427551 6 42810306 42810401 96 + 0.371 0.190 -1.298
ENSG00000112624 E010 0.0000000       6 42821056 42821213 158 +      
ENSG00000112624 E011 4.2030837 0.0038204385 3.277560e-01 0.4712322378 6 42822018 42822063 46 + 0.686 0.685 -0.005
ENSG00000112624 E012 5.0158288 0.0158208960 2.650740e-01 0.4030946725 6 42822796 42822844 49 + 0.750 0.732 -0.074
ENSG00000112624 E013 5.6759152 0.0127536833 4.360416e-02 0.0976531829 6 42822935 42823003 69 + 0.832 0.685 -0.590
ENSG00000112624 E014 40.4394999 0.0007295728 2.054658e-04 0.0009873895 6 42828493 42829581 1089 + 1.591 1.558 -0.113
ENSG00000112624 E015 30.3248643 0.0008021709 6.028833e-05 0.0003328508 6 42829582 42830172 591 + 1.484 1.391 -0.322
ENSG00000112624 E016 11.7152326 0.0767127292 3.287220e-01 0.4721982274 6 42852092 42852197 106 + 1.064 1.081 0.064
ENSG00000112624 E017 10.5488711 0.0422196044 1.144858e-01 0.2120924633 6 42853638 42853738 101 + 1.042 0.992 -0.184
ENSG00000112624 E018 7.0466693 0.0613493951 3.796191e-01 0.5238840631 6 42855856 42855917 62 + 0.866 0.883 0.062
ENSG00000112624 E019 11.0066386 0.0016785220 4.889994e-02 0.1072017457 6 42857091 42857236 146 + 1.057 1.014 -0.158
ENSG00000112624 E020 9.5122396 0.0018060878 4.590476e-02 0.1018649914 6 42860262 42860356 95 + 1.003 0.939 -0.238
ENSG00000112624 E021 11.5730950 0.0092156489 1.863093e-01 0.3091102627 6 42862510 42862612 103 + 1.058 1.078 0.076
ENSG00000112624 E022 178.7213921 0.0485815534 1.867149e-04 0.0009066870 6 42864659 42868558 3900 + 2.074 2.435 1.206