ENSG00000112592

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230354 ENSG00000112592 HEK293_OSMI2_2hA HEK293_TMG_2hB TBP protein_coding protein_coding 26.361 26.32576 29.99666 2.733617 0.2536073 0.1882594 7.978803 8.954976 9.835718 1.0464552 0.6074135 0.1351968 0.3032583 0.3443667 0.3276000 -0.01676667 9.306512e-01 4.049071e-09 FALSE TRUE
ENST00000392092 ENSG00000112592 HEK293_OSMI2_2hA HEK293_TMG_2hB TBP protein_coding protein_coding 26.361 26.32576 29.99666 2.733617 0.2536073 0.1882594 11.954962 13.232525 10.267699 1.9191311 0.8610120 -0.3656608 0.4628208 0.4995333 0.3427000 -0.15683333 5.961963e-02 4.049071e-09 FALSE TRUE
ENST00000421512 ENSG00000112592 HEK293_OSMI2_2hA HEK293_TMG_2hB TBP protein_coding protein_coding 26.361 26.32576 29.99666 2.733617 0.2536073 0.1882594 5.435641 3.444205 8.645841 0.4329875 0.5861503 1.3253203 0.1971667 0.1301667 0.2880333 0.15786667 4.049071e-09 4.049071e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112592 E001 8.713808 0.0256088832 5.401957e-01 6.713668e-01 6 170554302 170554332 31 + 1.028 0.951 -0.285
ENSG00000112592 E002 23.730037 0.0008518607 2.140494e-02 5.444113e-02 6 170554333 170554368 36 + 1.473 1.322 -0.521
ENSG00000112592 E003 32.003246 0.0007707632 5.235559e-01 6.572208e-01 6 170554369 170554378 10 + 1.532 1.502 -0.101
ENSG00000112592 E004 130.463472 0.0007591299 1.255455e-01 2.279273e-01 6 170554379 170554463 85 + 2.140 2.099 -0.137
ENSG00000112592 E005 0.147249 0.0434728357 4.664070e-01   6 170554605 170554704 100 + 0.125 0.000 -8.653
ENSG00000112592 E006 34.836637 0.0008170444 6.552428e-01 7.651763e-01 6 170556879 170556881 3 + 1.561 1.544 -0.058
ENSG00000112592 E007 149.472585 0.0002731208 1.252716e-01 2.275216e-01 6 170556882 170556941 60 + 2.197 2.163 -0.113
ENSG00000112592 E008 237.271985 0.0002210638 1.954940e-05 1.215642e-04 6 170556942 170557083 142 + 2.426 2.341 -0.284
ENSG00000112592 E009 384.732187 0.0001871542 5.476916e-04 2.338273e-03 6 170561791 170562233 443 + 2.616 2.566 -0.165
ENSG00000112592 E010 211.925218 0.0001902588 9.586865e-01 9.781202e-01 6 170564545 170564632 88 + 2.324 2.333 0.029
ENSG00000112592 E011 221.304443 0.0006691784 3.442338e-01 4.882973e-01 6 170566918 170567009 92 + 2.355 2.340 -0.051
ENSG00000112592 E012 11.398602 0.0015320116 2.463805e-07 2.320460e-06 6 170567226 170567505 280 + 1.301 0.784 -1.904
ENSG00000112592 E013 238.183516 0.0002078475 8.324952e-01 8.950379e-01 6 170569612 170569740 129 + 2.371 2.386 0.049
ENSG00000112592 E014 134.728718 0.0002577177 4.796129e-01 6.179816e-01 6 170569741 170569779 39 + 2.117 2.148 0.105
ENSG00000112592 E015 186.718897 0.0002412189 5.708415e-01 6.972789e-01 6 170571410 170571504 95 + 2.262 2.287 0.082
ENSG00000112592 E016 419.042687 0.0013365243 2.955527e-15 1.052671e-13 6 170572186 170572870 685 + 2.513 2.696 0.611