ENSG00000112541

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000539869 ENSG00000112541 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE10A protein_coding protein_coding 1.405258 0.7837009 2.459391 0.08679669 0.05309817 1.637488 0.21680623 0.08901756 0.40682308 0.01796018 0.05823597 2.0736789 0.13911250 0.11190000 0.16513333 0.05323333 6.925516e-01 9.556635e-06 FALSE TRUE
ENST00000647989 ENSG00000112541 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE10A protein_coding processed_transcript 1.405258 0.7837009 2.459391 0.08679669 0.05309817 1.637488 0.40339507 0.00000000 0.97766131 0.00000000 0.18975904 6.6259445 0.23985417 0.00000000 0.39806667 0.39806667 9.556635e-06 9.556635e-06 FALSE TRUE
ENST00000648917 ENSG00000112541 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE10A protein_coding protein_coding 1.405258 0.7837009 2.459391 0.08679669 0.05309817 1.637488 0.02939406 0.06144779 0.00000000 0.01674999 0.00000000 -2.8368895 0.03445000 0.07560000 0.00000000 -0.07560000 3.674593e-03 9.556635e-06 FALSE TRUE
ENST00000649273 ENSG00000112541 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE10A protein_coding nonsense_mediated_decay 1.405258 0.7837009 2.459391 0.08679669 0.05309817 1.637488 0.12753324 0.25846933 0.21926125 0.05039369 0.21926125 -0.2277647 0.10642500 0.35420000 0.09193333 -0.26226667 1.920855e-01 9.556635e-06 FALSE TRUE
ENST00000676766 ENSG00000112541 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE10A protein_coding protein_coding 1.405258 0.7837009 2.459391 0.08679669 0.05309817 1.637488 0.28036447 0.26227441 0.38705626 0.13124338 0.19401081 0.5442821 0.21005833 0.30280000 0.15496667 -0.14783333 8.456672e-01 9.556635e-06 FALSE TRUE
ENST00000676767 ENSG00000112541 HEK293_OSMI2_2hA HEK293_TMG_2hB PDE10A protein_coding nonsense_mediated_decay 1.405258 0.7837009 2.459391 0.08679669 0.05309817 1.637488 0.07477676 0.03139569 0.07840332 0.03139569 0.07840332 1.0946200 0.06080417 0.05106667 0.03060000 -0.02046667 8.719561e-01 9.556635e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112541 E001 0.1482932 0.0422270196 0.1557293760   6 165327287 165327288 2 - 0.000 0.193 11.825
ENSG00000112541 E002 0.4782907 0.0229607343 0.0079328991 0.0236113736 6 165327289 165327313 25 - 0.000 0.428 15.635
ENSG00000112541 E003 0.4782907 0.0229607343 0.0079328991 0.0236113736 6 165327314 165327383 70 - 0.000 0.428 15.635
ENSG00000112541 E004 1.2114379 0.0108647759 0.0000234192 0.0001429164 6 165327384 165327498 115 - 0.000 0.692 16.713
ENSG00000112541 E005 90.2928886 0.0058135026 0.1565188228 0.2704736059 6 165327499 165331049 3551 - 1.939 1.867 -0.242
ENSG00000112541 E006 9.9300056 0.0069121836 0.0041763271 0.0136398413 6 165331050 165331403 354 - 1.084 0.692 -1.507
ENSG00000112541 E007 62.0532552 0.0005027828 0.0338318353 0.0794188531 6 165331404 165333127 1724 - 1.725 1.820 0.319
ENSG00000112541 E008 0.1451727 0.0432135127 1.0000000000   6 165333128 165333293 166 - 0.075 0.000 -12.934
ENSG00000112541 E009 14.2704517 0.0317206295 0.4559099268 0.5963888102 6 165336123 165336211 89 - 1.122 1.206 0.297
ENSG00000112541 E010 1.0393897 0.0119401861 0.0888699044 0.1733878825 6 165336212 165336644 433 - 0.366 0.000 -15.383
ENSG00000112541 E011 14.3193632 0.0022210180 0.0197549517 0.0509678238 6 165339278 165339358 81 - 1.078 1.290 0.755
ENSG00000112541 E012 14.6406822 0.0013136115 0.2750447111 0.4142990808 6 165343391 165343502 112 - 1.123 1.223 0.354
ENSG00000112541 E013 19.5034206 0.0067961798 0.1252097040 0.2274357432 6 165379194 165379366 173 - 1.227 1.359 0.462
ENSG00000112541 E014 0.1472490 0.0432879144 1.0000000000   6 165381541 165381597 57 - 0.075 0.000 -12.933
ENSG00000112541 E015 21.8675895 0.0010281757 0.0024395961 0.0085807316 6 165388298 165388453 156 - 1.237 1.463 0.787
ENSG00000112541 E016 18.8526499 0.0012401168 0.2030091564 0.3299847435 6 165392646 165392796 151 - 1.222 1.326 0.364
ENSG00000112541 E017 13.8255246 0.0147723127 0.6817742428 0.7853920876 6 165395181 165395264 84 - 1.117 1.161 0.155
ENSG00000112541 E018 8.8813126 0.0020317793 0.9251281820 0.9568781492 6 165396317 165396339 23 - 0.960 0.947 -0.050
ENSG00000112541 E019 13.2932593 0.0135789651 0.5665305288 0.6934907193 6 165396340 165396459 120 - 1.135 1.067 -0.247
ENSG00000112541 E020 18.1012573 0.0040521027 0.8147598381 0.8826267222 6 165413501 165413687 187 - 1.246 1.223 -0.082
ENSG00000112541 E021 13.6411100 0.0013581263 0.5519605180 0.6813534960 6 165416189 165416281 93 - 1.104 1.160 0.200
ENSG00000112541 E022 0.4407149 0.0215416744 0.7385441532 0.8284041410 6 165418353 165418507 155 - 0.139 0.193 0.567
ENSG00000112541 E023 0.1451727 0.0432135127 1.0000000000   6 165418508 165418551 44 - 0.075 0.000 -12.934
ENSG00000112541 E024 14.0183370 0.0013471015 0.4787379353 0.6171648847 6 165418635 165418777 143 - 1.111 1.177 0.236
ENSG00000112541 E025 8.0764087 0.0028122967 0.7365505467 0.8269954686 6 165428658 165428709 52 - 0.932 0.888 -0.168
ENSG00000112541 E026 11.0736867 0.0018099233 0.8226100886 0.8881668717 6 165430287 165430345 59 - 1.049 1.022 -0.098
ENSG00000112541 E027 9.1336381 0.0282092514 0.7499913631 0.8367857504 6 165431422 165431472 51 - 0.960 0.997 0.140
ENSG00000112541 E028 15.8249684 0.0017052969 0.5494150592 0.6791446813 6 165432974 165433129 156 - 1.202 1.143 -0.211
ENSG00000112541 E029 15.6680229 0.0013823398 0.0119918664 0.0335111755 6 165435237 165435377 141 - 1.237 0.974 -0.950
ENSG00000112541 E030 8.7282780 0.0021732430 0.0486938987 0.1068440240 6 165448928 165448977 50 - 1.003 0.739 -1.015
ENSG00000112541 E031 13.8250166 0.0105334466 0.0050219889 0.0159917020 6 165450242 165450362 121 - 1.202 0.856 -1.273
ENSG00000112541 E032 0.0000000       6 165454578 165454695 118 -      
ENSG00000112541 E033 0.0000000       6 165466420 165466532 113 -      
ENSG00000112541 E034 9.1038221 0.0397785864 0.0818860082 0.1625186854 6 165482315 165482343 29 - 1.028 0.741 -1.100
ENSG00000112541 E035 0.0000000       6 165503005 165503356 352 -      
ENSG00000112541 E036 0.1451727 0.0432135127 1.0000000000   6 165542655 165543439 785 - 0.075 0.000 -12.934
ENSG00000112541 E037 10.5188004 0.0023033338 0.0376988404 0.0867655439 6 165543440 165543568 129 - 1.078 0.820 -0.967
ENSG00000112541 E038 1.4791742 0.0245065299 0.0344430144 0.0806098527 6 165576412 165576449 38 - 0.461 0.000 -15.729
ENSG00000112541 E039 1.0330470 0.0119153820 0.0889083831 0.1734540241 6 165576450 165576539 90 - 0.366 0.000 -15.383
ENSG00000112541 E040 0.0000000       6 165600166 165600778 613 -      
ENSG00000112541 E041 0.0000000       6 165611354 165611496 143 -      
ENSG00000112541 E042 0.5514428 0.0197130366 0.0077674403 0.0231947016 6 165654813 165655336 524 - 0.000 0.429 15.651
ENSG00000112541 E043 0.2214452 0.0393214738 0.1546812041   6 165660069 165660954 886 - 0.000 0.194 14.142
ENSG00000112541 E044 0.0000000       6 165660955 165661578 624 -      
ENSG00000112541 E045 6.9206149 0.0028402931 0.4220915338 0.5652522500 6 165661947 165663241 1295 - 0.892 0.781 -0.431
ENSG00000112541 E046 0.0000000       6 165711019 165711153 135 -      
ENSG00000112541 E047 0.1515154 0.0429234186 1.0000000000   6 165778326 165780268 1943 - 0.075 0.000 -12.935
ENSG00000112541 E048 0.1472490 0.0432879144 1.0000000000   6 165780269 165781923 1655 - 0.075 0.000 -12.933
ENSG00000112541 E049 0.1472490 0.0432879144 1.0000000000   6 165786479 165786677 199 - 0.075 0.000 -12.933
ENSG00000112541 E050 0.2987644 0.0272497285 0.7130737653   6 165790096 165790581 486 - 0.139 0.000 -13.881
ENSG00000112541 E051 0.4545463 0.6662938127 0.7494966811 0.8364450779 6 165790582 165791910 1329 - 0.197 0.000 -13.711
ENSG00000112541 E052 0.1472490 0.0432879144 1.0000000000   6 165791911 165792093 183 - 0.075 0.000 -12.933
ENSG00000112541 E053 0.1472490 0.0432879144 1.0000000000   6 165792094 165792227 134 - 0.075 0.000 -12.933
ENSG00000112541 E054 0.1472490 0.0432879144 1.0000000000   6 165792228 165792335 108 - 0.075 0.000 -12.933
ENSG00000112541 E055 0.0000000       6 165823645 165824203 559 -      
ENSG00000112541 E056 0.0000000       6 165828530 165828701 172 -      
ENSG00000112541 E057 0.0000000       6 165872269 165873443 1175 -      
ENSG00000112541 E058 0.0000000       6 165893825 165893841 17 -      
ENSG00000112541 E059 0.0000000       6 165893842 165894300 459 -      
ENSG00000112541 E060 0.0000000       6 165894301 165896237 1937 -      
ENSG00000112541 E061 0.0000000       6 165901820 165901880 61 -      
ENSG00000112541 E062 0.0000000       6 165901881 165901927 47 -      
ENSG00000112541 E063 0.0000000       6 165901928 165902847 920 -      
ENSG00000112541 E064 0.0000000       6 165902848 165902883 36 -      
ENSG00000112541 E065 0.0000000       6 165902884 165902912 29 -      
ENSG00000112541 E066 0.4418608 0.0265533455 0.4286948248 0.5714171526 6 165908802 165909080 279 - 0.195 0.000 -14.383
ENSG00000112541 E067 0.0000000       6 165910808 165910932 125 -      
ENSG00000112541 E068 1.2252467 0.1403243599 0.4458875412 0.5874396338 6 165918211 165924231 6021 - 0.366 0.194 -1.239
ENSG00000112541 E069 0.1472490 0.0432879144 1.0000000000   6 165924232 165924659 428 - 0.075 0.000 -12.933
ENSG00000112541 E070 0.0000000       6 165938914 165939455 542 -      
ENSG00000112541 E071 0.7395785 0.1184659353 0.3148751405 0.4576306156 6 165939456 165940588 1133 - 0.139 0.330 1.592
ENSG00000112541 E072 0.5138669 0.0206330802 0.7366761601 0.8270972911 6 165940589 165940766 178 - 0.139 0.194 0.571
ENSG00000112541 E073 0.1472490 0.0432879144 1.0000000000   6 165946772 165947063 292 - 0.075 0.000 -12.933
ENSG00000112541 E074 0.1472490 0.0432879144 1.0000000000   6 165947064 165947220 157 - 0.075 0.000 -12.933
ENSG00000112541 E075 0.0000000       6 165948223 165948463 241 -      
ENSG00000112541 E076 0.1817044 0.0392553046 0.1553420704   6 165948464 165948608 145 - 0.000 0.193 14.139
ENSG00000112541 E077 0.3268771 0.0289155637 0.4247473738   6 165948609 165949254 646 - 0.075 0.193 1.570
ENSG00000112541 E078 0.0000000       6 165949255 165949619 365 -      
ENSG00000112541 E079 0.0000000       6 165949620 165949914 295 -      
ENSG00000112541 E080 0.0000000       6 165986108 165986603 496 -      
ENSG00000112541 E081 1.7274724 0.0085220490 0.8700485890 0.9203977132 6 165987529 165988117 589 - 0.400 0.428 0.154