ENSG00000112531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361195 ENSG00000112531 HEK293_OSMI2_2hA HEK293_TMG_2hB QKI protein_coding protein_coding 26.22462 7.026063 44.39962 0.2070721 0.2573182 2.658032 5.2175034 3.171374 4.1626004 0.2428865 1.1766793 0.3912969 0.2849417 0.4542333 0.093466667 -0.3607667 6.534160e-05 4.38867e-26 FALSE TRUE
ENST00000361752 ENSG00000112531 HEK293_OSMI2_2hA HEK293_TMG_2hB QKI protein_coding protein_coding 26.22462 7.026063 44.39962 0.2070721 0.2573182 2.658032 3.3861276 0.000000 10.8346338 0.0000000 0.7622045 10.0827656 0.1042458 0.0000000 0.244233333 0.2442333 4.388670e-26 4.38867e-26 FALSE TRUE
ENST00000537883 ENSG00000112531 HEK293_OSMI2_2hA HEK293_TMG_2hB QKI protein_coding protein_coding 26.22462 7.026063 44.39962 0.2070721 0.2573182 2.658032 0.5307316 1.682814 0.2170572 0.4406760 0.1125822 -2.8982963 0.0590875 0.2430333 0.004933333 -0.2381000 1.027186e-07 4.38867e-26 FALSE FALSE
ENST00000544823 ENSG00000112531 HEK293_OSMI2_2hA HEK293_TMG_2hB QKI protein_coding protein_coding 26.22462 7.026063 44.39962 0.2070721 0.2573182 2.658032 15.0255805 1.755933 25.4072607 0.9164728 0.3722060 3.8473061 0.4723958 0.2430333 0.572333333 0.3293000 4.939415e-01 4.38867e-26 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112531 E001 1.9337205 0.0993637785 5.595779e-02 1.196262e-01 6 163414000 163414642 643 + 0.410 0.000 -16.479
ENSG00000112531 E002 5.7574652 0.0027972020 1.287535e-03 4.934949e-03 6 163414643 163414717 75 + 0.747 0.274 -2.385
ENSG00000112531 E003 60.7242502 0.0046523179 2.679130e-22 2.205793e-20 6 163414718 163415169 452 + 1.692 0.950 -2.610
ENSG00000112531 E004 38.6311009 0.0157382473 1.360716e-10 2.349681e-09 6 163415170 163415193 24 + 1.495 0.906 -2.101
ENSG00000112531 E005 81.8137706 0.0077283314 8.637787e-15 2.870379e-13 6 163415194 163415237 44 + 1.803 1.409 -1.346
ENSG00000112531 E006 142.7830173 0.0006287412 3.841011e-20 2.490308e-18 6 163415238 163415335 98 + 2.024 1.853 -0.576
ENSG00000112531 E007 0.0000000       6 163416315 163416486 172 +      
ENSG00000112531 E008 0.0000000       6 163423134 163423207 74 +      
ENSG00000112531 E009 0.0000000       6 163423208 163423213 6 +      
ENSG00000112531 E010 0.0000000       6 163423214 163423592 379 +      
ENSG00000112531 E011 0.0000000       6 163428995 163429017 23 +      
ENSG00000112531 E012 0.1451727 0.0439171908 1.000000e+00   6 163455216 163455278 63 + 0.049 0.000 -12.760
ENSG00000112531 E013 131.9106916 0.0002777197 2.983813e-13 7.922558e-12 6 163455279 163455330 52 + 1.979 1.908 -0.240
ENSG00000112531 E014 182.6196365 0.0028072184 2.229086e-09 3.096676e-08 6 163455331 163455421 91 + 2.112 2.088 -0.083
ENSG00000112531 E015 0.1451727 0.0439171908 1.000000e+00   6 163457381 163457551 171 + 0.049 0.000 -12.760
ENSG00000112531 E016 206.2439813 0.0066798832 3.490512e-06 2.575930e-05 6 163478780 163478896 117 + 2.162 2.157 -0.017
ENSG00000112531 E017 0.5975289 0.0298279931 4.432219e-01 5.847858e-01 6 163534959 163534981 23 + 0.171 0.000 -14.761
ENSG00000112531 E018 181.4219732 0.0042345397 1.769387e-05 1.110539e-04 6 163534982 163535079 98 + 2.101 2.137 0.122
ENSG00000112531 E019 112.4287949 0.0013482207 2.096666e-03 7.523859e-03 6 163535080 163535125 46 + 1.884 1.986 0.340
ENSG00000112531 E020 138.5407043 0.0053054913 6.266767e-03 1.931132e-02 6 163561982 163562069 88 + 1.974 2.069 0.319
ENSG00000112531 E021 89.8758802 0.0094395341 4.135985e-02 9.355038e-02 6 163563420 163563443 24 + 1.789 1.886 0.327
ENSG00000112531 E022 285.0310546 0.0124254907 1.441740e-03 5.445567e-03 6 163563444 163563719 276 + 2.295 2.339 0.149
ENSG00000112531 E023 21.6527449 0.0216343878 4.424466e-06 3.187321e-05 6 163563720 163564666 947 + 1.250 0.796 -1.676
ENSG00000112531 E024 27.8508337 0.0140158867 6.397290e-04 2.679166e-03 6 163564667 163565945 1279 + 1.328 1.178 -0.531
ENSG00000112531 E025 35.9080833 0.0005655707 1.389408e-11 2.827529e-10 6 163565946 163566457 512 + 1.457 1.028 -1.517
ENSG00000112531 E026 20.0396615 0.0009095620 6.225004e-06 4.337127e-05 6 163566458 163566720 263 + 1.213 0.904 -1.126
ENSG00000112531 E027 159.9289220 0.0006881442 4.826023e-09 6.317111e-08 6 163566721 163566795 75 + 2.051 2.067 0.055
ENSG00000112531 E028 78.0659012 0.0261440598 5.943541e-02 1.256709e-01 6 163566796 163569437 2642 + 1.733 1.826 0.314
ENSG00000112531 E029 23.6481737 0.0633393808 4.374568e-02 9.792149e-02 6 163569438 163570145 708 + 1.104 1.687 2.026
ENSG00000112531 E030 1996.7780694 0.0100726327 1.579315e-17 7.534537e-16 6 163570694 163578592 7899 + 3.049 3.488 1.462