ENSG00000112514

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374484 ENSG00000112514 HEK293_OSMI2_2hA HEK293_TMG_2hB CUTA protein_coding nonsense_mediated_decay 369.4147 668.6306 197.911 15.87788 0.2471132 -1.756306 44.16242 77.53295 22.70049 7.226141 1.5486067 -1.771637 0.1155167 0.1165333 0.1146667 -0.001866667 1.00000000 0.00239463 TRUE  
ENST00000440279 ENSG00000112514 HEK293_OSMI2_2hA HEK293_TMG_2hB CUTA protein_coding protein_coding 369.4147 668.6306 197.911 15.87788 0.2471132 -1.756306 79.60230 152.78148 38.53904 2.745151 0.7370709 -1.986797 0.2057833 0.2285667 0.1947333 -0.033833333 0.00239463 0.00239463 FALSE  
ENST00000488034 ENSG00000112514 HEK293_OSMI2_2hA HEK293_TMG_2hB CUTA protein_coding protein_coding 369.4147 668.6306 197.911 15.87788 0.2471132 -1.756306 68.58741 112.71947 43.50090 8.257231 1.6940391 -1.373416 0.1968167 0.1682000 0.2197667 0.051566667 0.02258079 0.00239463 FALSE  
ENST00000607266 ENSG00000112514 HEK293_OSMI2_2hA HEK293_TMG_2hB CUTA protein_coding protein_coding 369.4147 668.6306 197.911 15.87788 0.2471132 -1.756306 93.67989 167.34445 47.23312 13.209045 3.2579613 -1.824731 0.2580125 0.2509333 0.2386667 -0.012266667 0.91025314 0.00239463 FALSE  
MSTRG.28142.5 ENSG00000112514 HEK293_OSMI2_2hA HEK293_TMG_2hB CUTA protein_coding   369.4147 668.6306 197.911 15.87788 0.2471132 -1.756306 44.31005 86.23072 30.08552 15.094253 5.2678234 -1.518821 0.1224542 0.1281333 0.1520333 0.023900000 0.79690860 0.00239463 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112514 E001 10.36298 0.0018128394 0.9888059642 0.997031627 6 33416442 33416534 93 - 0.943 0.939 -0.014
ENSG00000112514 E002 11.61843 0.0014783165 0.4751427964 0.613886948 6 33416535 33416541 7 - 1.055 0.971 -0.311
ENSG00000112514 E003 13.27597 0.0013054059 0.1450465545 0.254896753 6 33416542 33416542 1 - 1.164 1.007 -0.568
ENSG00000112514 E004 35.11428 0.0005885247 0.0762419311 0.153494210 6 33416543 33416549 7 - 1.324 1.462 0.480
ENSG00000112514 E005 56.18882 0.0052205071 0.0011766965 0.004562643 6 33416550 33416550 1 - 1.430 1.678 0.848
ENSG00000112514 E006 56.96171 0.0046083424 0.0007095323 0.002933179 6 33416551 33416551 1 - 1.430 1.684 0.869
ENSG00000112514 E007 137.22799 0.0003326619 0.6243188935 0.740670125 6 33416552 33416560 9 - 2.008 2.026 0.059
ENSG00000112514 E008 1200.03683 0.0017841973 0.0050053769 0.015944015 6 33416561 33416618 58 - 2.904 2.970 0.220
ENSG00000112514 E009 1429.51898 0.0024907384 0.0079437744 0.023638811 6 33416619 33416660 42 - 2.977 3.046 0.229
ENSG00000112514 E010 2538.76273 0.0017975895 0.1707157990 0.289086891 6 33416661 33416748 88 - 3.262 3.288 0.089
ENSG00000112514 E011 2409.05910 0.0010324534 0.6947938955 0.795538506 6 33416749 33416776 28 - 3.268 3.260 -0.027
ENSG00000112514 E012 20.65039 0.0035594287 0.0646126570 0.134396228 6 33416777 33416919 143 - 1.362 1.195 -0.584
ENSG00000112514 E013 2797.52689 0.0007092506 0.9135033719 0.949196799 6 33416920 33416969 50 - 3.326 3.326 0.000
ENSG00000112514 E014 30.76830 0.0119367208 0.9534584235 0.974865626 6 33416970 33417096 127 - 1.386 1.394 0.028
ENSG00000112514 E015 2313.20522 0.0009852726 0.3651575263 0.509497175 6 33417097 33417142 46 - 3.232 3.246 0.046
ENSG00000112514 E016 24.03265 0.0287867965 0.4487161134 0.589989118 6 33417143 33417246 104 - 1.363 1.264 -0.346
ENSG00000112514 E017 15.52733 0.0473635448 0.8162574753 0.883735976 6 33417247 33417250 4 - 1.080 1.109 0.104
ENSG00000112514 E018 2783.78515 0.0001986447 0.0026957659 0.009361111 6 33417251 33417310 60 - 3.350 3.317 -0.109
ENSG00000112514 E019 24.09540 0.0008203006 0.8952414383 0.937052083 6 33417311 33417480 170 - 1.296 1.282 -0.047
ENSG00000112514 E020 4601.52968 0.0024475245 0.2862182716 0.426618355 6 33417481 33417695 215 - 3.562 3.537 -0.081
ENSG00000112514 E021 611.55720 0.0008461790 0.0034363735 0.011542742 6 33417696 33417816 121 - 2.609 2.675 0.219
ENSG00000112514 E022 314.54641 0.0009585302 0.2506562372 0.386725891 6 33417817 33417868 52 - 2.350 2.381 0.105
ENSG00000112514 E023 440.60265 0.0022622986 0.8496486932 0.906698113 6 33417869 33417958 90 - 2.529 2.521 -0.029
ENSG00000112514 E024 626.05287 0.0043541252 0.0954363626 0.183539739 6 33417959 33417983 25 - 2.727 2.663 -0.210
ENSG00000112514 E025 688.09090 0.0033004697 0.1630734413 0.279149680 6 33417984 33418010 27 - 2.755 2.707 -0.160
ENSG00000112514 E026 632.62017 0.0030071867 0.0405813153 0.092089603 6 33418011 33418086 76 - 2.735 2.667 -0.225
ENSG00000112514 E027 962.92830 0.0046421612 0.2139367063 0.343172207 6 33418087 33418201 115 - 2.899 2.854 -0.151
ENSG00000112514 E028 60.94822 0.0096723219 0.3834861337 0.527690357 6 33418202 33418317 116 - 1.614 1.683 0.234