ENSG00000112394

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368851 ENSG00000112394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A10 protein_coding protein_coding 14.97992 13.82944 15.79598 1.231 0.9221728 0.1916847 2.7670583 1.420015 4.2902368 0.1258648 0.11622445 1.5883858 0.17700000 0.10360000 0.27390000 0.170300000 1.041868e-06 5.22094e-12 FALSE TRUE
ENST00000419619 ENSG00000112394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A10 protein_coding protein_coding 14.97992 13.82944 15.79598 1.231 0.9221728 0.1916847 0.7292911 2.179521 0.0000000 0.4853371 0.00000000 -7.7744716 0.05798750 0.16330000 0.00000000 -0.163300000 5.220940e-12 5.22094e-12 FALSE TRUE
ENST00000439288 ENSG00000112394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A10 protein_coding protein_coding 14.97992 13.82944 15.79598 1.231 0.9221728 0.1916847 6.2599901 5.720968 6.3313754 1.2286005 0.44441136 0.1460170 0.40955833 0.40580000 0.40076667 -0.005033333 1.000000e+00 5.22094e-12 FALSE TRUE
MSTRG.28802.4 ENSG00000112394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A10 protein_coding   14.97992 13.82944 15.79598 1.231 0.9221728 0.1916847 3.3756370 2.929027 2.9706461 0.2846407 0.04466364 0.0202863 0.23234583 0.21606667 0.18960000 -0.026466667 8.110829e-01 5.22094e-12 TRUE TRUE
MSTRG.28802.6 ENSG00000112394 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC16A10 protein_coding   14.97992 13.82944 15.79598 1.231 0.9221728 0.1916847 0.6880992 1.042741 0.9465085 0.6363091 0.27382833 -0.1383007 0.05009167 0.07186667 0.05856667 -0.013300000 9.334242e-01 5.22094e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112394 E001 1.1898584 0.1224560755 7.005523e-01 7.999948e-01 6 111087386 111087502 117 + 0.358 0.265 -0.609
ENSG00000112394 E002 1.3350311 0.0370825655 4.967950e-01 6.333876e-01 6 111087503 111087510 8 + 0.404 0.263 -0.887
ENSG00000112394 E003 15.2533101 0.0012356302 1.778497e-10 3.006165e-09 6 111087511 111087653 143 + 1.386 0.674 -2.646
ENSG00000112394 E004 16.4218657 0.0011007546 5.764029e-12 1.246835e-10 6 111087654 111087735 82 + 1.425 0.674 -2.783
ENSG00000112394 E005 26.4089989 0.0213077686 2.155957e-02 5.476488e-02 6 111087736 111087899 164 + 1.522 1.268 -0.881
ENSG00000112394 E006 70.9602955 0.0004194643 2.724316e-02 6.648386e-02 6 111087900 111088095 196 + 1.822 1.892 0.236
ENSG00000112394 E007 104.1447739 0.0018244268 7.347072e-06 5.032470e-05 6 111172695 111172839 145 + 1.950 2.098 0.497
ENSG00000112394 E008 0.4438354 0.0637441275 3.259973e-01 4.694376e-01 6 111173438 111173525 88 + 0.099 0.260 1.680
ENSG00000112394 E009 237.2453070 0.0009196787 2.132101e-21 1.600951e-19 6 111177212 111177665 454 + 2.274 2.481 0.689
ENSG00000112394 E010 5.5386607 0.0031866890 3.950593e-04 1.755555e-03 6 111177666 111177712 47 + 0.582 1.021 1.753
ENSG00000112394 E011 19.7463320 0.0009456207 9.713723e-26 1.138760e-23 6 111178402 111178714 313 + 0.729 1.614 3.203
ENSG00000112394 E012 0.2955422 0.0290093041 7.014226e-01   6 111193293 111193324 32 + 0.099 0.150 0.689
ENSG00000112394 E013 87.0428772 0.0004907078 1.829272e-03 6.693515e-03 6 111206592 111206735 144 + 1.901 1.997 0.323
ENSG00000112394 E014 121.1095560 0.0025647492 1.581706e-02 4.232757e-02 6 111218814 111219042 229 + 2.055 2.127 0.243
ENSG00000112394 E015 665.6423413 0.0009961956 6.692720e-32 1.279431e-29 6 111222003 111231194 9192 + 2.890 2.709 -0.602
ENSG00000112394 E016 0.0000000       6 111246732 111246804 73 +      
ENSG00000112394 E017 5.1803622 0.0828182531 2.305671e-01 3.631396e-01 6 111256057 111256140 84 + 0.706 0.880 0.690
ENSG00000112394 E018 2.3896445 0.0119642107 4.614189e-01 6.013817e-01 6 111256838 111256976 139 + 0.484 0.590 0.498