ENSG00000112367

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000454215 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding protein_coding 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 0.6090252 0.0000000 0.6503003 0.0000000 0.6503003 6.0450503 0.05235833 0.00000000 0.05013333 0.0501333333 0.92990641 0.02041238 FALSE TRUE
ENST00000674575 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding nonsense_mediated_decay 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 1.6611469 0.4718724 2.0771355 0.2421855 1.0056463 2.1148011 0.15747917 0.09493333 0.17033333 0.0754000000 0.74703232 0.02041238 FALSE TRUE
ENST00000675004 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding nonsense_mediated_decay 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 0.7271331 0.7789773 1.4615127 0.3323837 0.2691837 0.8992442 0.09092917 0.12303333 0.12336667 0.0003333333 0.97072017 0.02041238 FALSE TRUE
ENST00000675009 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding nonsense_mediated_decay 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 0.6290584 0.9751001 0.1212892 0.2828629 0.1212892 -2.9075220 0.09920000 0.16143333 0.01110000 -0.1503333333 0.02041238 0.02041238 FALSE TRUE
ENST00000675772 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding protein_coding 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 0.6913572 0.0000000 1.8718356 0.0000000 1.2041849 7.5559968 0.05707083 0.00000000 0.15050000 0.1505000000 0.26636916 0.02041238 FALSE TRUE
ENST00000675831 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding protein_coding 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 1.3980312 1.6106579 2.1203203 0.3064417 1.0727395 0.3944908 0.18868333 0.27303333 0.19216667 -0.0808666667 0.79793344 0.02041238 FALSE TRUE
ENST00000675887 ENSG00000112367 HEK293_OSMI2_2hA HEK293_TMG_2hB FIG4 protein_coding nonsense_mediated_decay 8.887574 5.796715 11.68755 0.7578138 0.6469867 1.010412 1.8712246 0.7584570 2.1798499 0.1652397 1.0911084 1.5107955 0.18197500 0.13843333 0.19746667 0.0590333333 1.00000000 0.02041238 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112367 E001 0.0000000       6 109690609 109690914 306 +      
ENSG00000112367 E002 0.0000000       6 109691216 109691248 33 +      
ENSG00000112367 E003 0.1472490 0.0439921244 8.353110e-01   6 109691249 109691264 16 + 0.097 0.000 -11.894
ENSG00000112367 E004 0.1472490 0.0439921244 8.353110e-01   6 109691265 109691265 1 + 0.097 0.000 -11.889
ENSG00000112367 E005 0.4439371 0.0216254353 2.083732e-01 3.365217e-01 6 109691266 109691278 13 + 0.243 0.000 -13.474
ENSG00000112367 E006 0.4439371 0.0216254353 2.083732e-01 3.365217e-01 6 109691279 109691279 1 + 0.243 0.000 -13.474
ENSG00000112367 E007 0.7708142 0.0152116730 4.191122e-01 5.623675e-01 6 109691280 109691280 1 + 0.301 0.153 -1.242
ENSG00000112367 E008 1.2492067 0.0133940620 4.749535e-01 6.137337e-01 6 109691281 109691285 5 + 0.398 0.266 -0.827
ENSG00000112367 E009 1.2492067 0.0133940620 4.749535e-01 6.137337e-01 6 109691286 109691287 2 + 0.398 0.266 -0.827
ENSG00000112367 E010 1.8664292 0.2613115195 5.464270e-01 6.766131e-01 6 109691288 109691294 7 + 0.511 0.358 -0.812
ENSG00000112367 E011 2.1598950 0.1474604948 6.676655e-01 7.748402e-01 6 109691295 109691295 1 + 0.544 0.429 -0.564
ENSG00000112367 E012 2.6360975 0.0999117640 6.117744e-01 7.308402e-01 6 109691296 109691302 7 + 0.602 0.493 -0.503
ENSG00000112367 E013 3.8498167 0.1178571590 5.186550e-01 6.528877e-01 6 109691303 109691311 9 + 0.740 0.596 -0.609
ENSG00000112367 E014 4.1465048 0.1189476727 4.095761e-01 5.531830e-01 6 109691312 109691312 1 + 0.778 0.596 -0.761
ENSG00000112367 E015 4.4389265 0.1019182228 3.022285e-01 4.440846e-01 6 109691313 109691314 2 + 0.812 0.596 -0.897
ENSG00000112367 E016 4.9570598 0.0670258018 3.028636e-01 4.447868e-01 6 109691315 109691316 2 + 0.845 0.642 -0.823
ENSG00000112367 E017 5.9879167 0.0215889788 4.952943e-02 1.083323e-01 6 109691317 109691322 6 + 0.942 0.642 -1.195
ENSG00000112367 E018 30.3798825 0.0142656170 7.185699e-04 2.965427e-03 6 109691323 109691416 94 + 1.597 1.283 -1.081
ENSG00000112367 E019 31.1874559 0.0304778887 7.651471e-03 2.290472e-02 6 109691417 109691464 48 + 1.605 1.302 -1.042
ENSG00000112367 E020 29.2594273 0.0184398791 2.499876e-03 8.762359e-03 6 109691465 109691501 37 + 1.577 1.282 -1.018
ENSG00000112367 E021 0.0000000       6 109695399 109695474 76 +      
ENSG00000112367 E022 0.6299079 0.0249285030 6.241470e-01 7.405726e-01 6 109695830 109695904 75 + 0.243 0.153 -0.827
ENSG00000112367 E023 0.1472490 0.0439921244 8.353110e-01   6 109697655 109697864 210 + 0.097 0.000 -11.889
ENSG00000112367 E024 0.0000000       6 109701569 109701722 154 +      
ENSG00000112367 E025 20.0433096 0.0186327217 5.508424e-03 1.731006e-02 6 109715078 109715079 2 + 1.420 1.122 -1.046
ENSG00000112367 E026 44.5312979 0.0016334329 3.604623e-04 1.620669e-03 6 109715080 109715176 97 + 1.729 1.520 -0.709
ENSG00000112367 E027 50.8759030 0.0004710644 8.947559e-06 6.016498e-05 6 109716445 109716568 124 + 1.795 1.563 -0.787
ENSG00000112367 E028 37.4205089 0.0031287444 9.418191e-04 3.760428e-03 6 109727109 109727157 49 + 1.661 1.441 -0.750
ENSG00000112367 E029 45.3473947 0.0005088943 6.629413e-02 1.372098e-01 6 109727158 109727265 108 + 1.704 1.606 -0.333
ENSG00000112367 E030 0.0000000       6 109730380 109730506 127 +      
ENSG00000112367 E031 29.7331352 0.0009111785 9.760075e-01 9.890263e-01 6 109732637 109732687 51 + 1.488 1.486 -0.009
ENSG00000112367 E032 0.0000000       6 109735132 109735149 18 +      
ENSG00000112367 E033 24.1378396 0.0009134574 8.389376e-01 8.993358e-01 6 109735150 109735155 6 + 1.407 1.392 -0.051
ENSG00000112367 E034 57.0815336 0.0004274949 2.143882e-01 3.437305e-01 6 109735156 109735298 143 + 1.741 1.797 0.192
ENSG00000112367 E035 2.0776189 0.2936950992 2.636133e-01 4.015281e-01 6 109735299 109736772 1474 + 0.575 0.274 -1.652
ENSG00000112367 E036 2.5077618 0.0060021023 5.955068e-01 7.175831e-01 6 109736773 109738324 1552 + 0.512 0.598 0.394
ENSG00000112367 E037 50.4897314 0.0016663864 8.314980e-01 8.943932e-01 6 109738325 109738453 129 + 1.718 1.706 -0.042
ENSG00000112367 E038 0.0000000       6 109738454 109738473 20 +      
ENSG00000112367 E039 0.0000000       6 109738474 109738567 94 +      
ENSG00000112367 E040 1.9389027 0.3049306708 3.213182e-01 4.645429e-01 6 109738568 109741443 2876 + 0.546 0.274 -1.518
ENSG00000112367 E041 29.3673814 0.0009428575 4.922399e-01 6.294354e-01 6 109741444 109741467 24 + 1.495 1.448 -0.161
ENSG00000112367 E042 42.7000047 0.0081001714 8.546193e-01 9.100801e-01 6 109741468 109741544 77 + 1.634 1.640 0.021
ENSG00000112367 E043 67.4484390 0.0004909572 3.596228e-01 5.039571e-01 6 109743110 109743272 163 + 1.850 1.809 -0.138
ENSG00000112367 E044 0.9921577 0.0126929048 1.480954e-01 2.590938e-01 6 109743273 109743646 374 + 0.176 0.430 1.757
ENSG00000112367 E045 0.2998086 0.0282266782 7.021136e-01   6 109743647 109743674 28 + 0.097 0.153 0.755
ENSG00000112367 E046 52.6028002 0.0004249292 8.627043e-01 9.154602e-01 6 109743675 109743772 98 + 1.727 1.735 0.027
ENSG00000112367 E047 0.0000000       6 109744667 109744761 95 +      
ENSG00000112367 E048 0.0000000       6 109758867 109759234 368 +      
ENSG00000112367 E049 68.9259088 0.0003586583 7.563946e-01 8.414736e-01 6 109760250 109760383 134 + 1.838 1.850 0.041
ENSG00000112367 E050 66.1508933 0.0004225765 9.759403e-01 9.889866e-01 6 109762091 109762207 117 + 1.823 1.823 0.000
ENSG00000112367 E051 0.2987644 0.0290785164 3.999196e-01   6 109762208 109762926 719 + 0.176 0.000 -12.889
ENSG00000112367 E052 0.0000000       6 109762927 109763936 1010 +      
ENSG00000112367 E053 46.4978003 0.0005186036 9.499343e-01 9.726845e-01 6 109763937 109763982 46 + 1.677 1.673 -0.014
ENSG00000112367 E054 0.0000000       6 109763983 109764419 437 +      
ENSG00000112367 E055 76.6148594 0.0004480889 5.935849e-01 7.159639e-01 6 109765013 109765161 149 + 1.899 1.877 -0.074
ENSG00000112367 E056 0.0000000       6 109766402 109766641 240 +      
ENSG00000112367 E057 72.0088020 0.0033758890 2.468557e-01 3.822600e-01 6 109766729 109766895 167 + 1.839 1.894 0.186
ENSG00000112367 E058 0.2214452 0.0558960075 2.866584e-01   6 109766896 109767208 313 + 0.000 0.154 13.135
ENSG00000112367 E059 0.0000000       6 109769125 109769745 621 +      
ENSG00000112367 E060 1.2178718 0.0104292313 4.686933e-01 6.080893e-01 6 109773839 109776921 3083 + 0.398 0.266 -0.828
ENSG00000112367 E061 69.0218672 0.0012623669 3.803211e-01 5.246078e-01 6 109776922 109777060 139 + 1.831 1.871 0.135
ENSG00000112367 E062 49.7161353 0.0029969192 2.462063e-01 3.815038e-01 6 109784970 109785028 59 + 1.682 1.748 0.226
ENSG00000112367 E063 0.5169874 0.0200326679 3.051072e-01 4.471492e-01 6 109785671 109785769 99 + 0.097 0.266 1.758
ENSG00000112367 E064 0.0000000       6 109786006 109786301 296 +      
ENSG00000112367 E065 77.2981026 0.0004671426 2.559729e-01 3.929320e-01 6 109786302 109786449 148 + 1.874 1.919 0.152
ENSG00000112367 E066 2.2123082 0.0424045517 5.603040e-01 6.883085e-01 6 109786450 109788746 2297 + 0.544 0.430 -0.562
ENSG00000112367 E067 0.4396707 0.0290728824 2.104312e-01 3.390506e-01 6 109788747 109788797 51 + 0.243 0.000 -13.473
ENSG00000112367 E068 0.4460135 0.0412974107 2.117224e-01 3.405169e-01 6 109788798 109788913 116 + 0.243 0.000 -13.474
ENSG00000112367 E069 0.5159433 0.3091299665 1.000000e+00 1.000000e+00 6 109788914 109788956 43 + 0.176 0.156 -0.211
ENSG00000112367 E070 0.8105550 0.0148296443 4.204675e-01 5.636725e-01 6 109788957 109789593 637 + 0.301 0.153 -1.241
ENSG00000112367 E071 55.6717235 0.0030359779 1.106941e-01 2.065485e-01 6 109789594 109789677 84 + 1.714 1.797 0.278
ENSG00000112367 E072 0.0000000       6 109789678 109791305 1628 +      
ENSG00000112367 E073 0.0000000       6 109791306 109791375 70 +      
ENSG00000112367 E074 76.5585239 0.0004788098 3.237651e-03 1.096623e-02 6 109791376 109791571 196 + 1.838 1.955 0.395
ENSG00000112367 E075 0.7426990 0.1261954892 1.471861e-01 2.578554e-01 6 109791572 109792581 1010 + 0.097 0.358 2.355
ENSG00000112367 E076 51.5918949 0.0006788760 3.038175e-05 1.805380e-04 6 109792582 109792664 83 + 1.629 1.831 0.684
ENSG00000112367 E077 0.1472490 0.0439921244 8.353110e-01   6 109795874 109796764 891 + 0.097 0.000 -11.889
ENSG00000112367 E078 53.7107899 0.0014620858 1.055182e-04 5.474190e-04 6 109796765 109796851 87 + 1.649 1.841 0.650
ENSG00000112367 E079 0.6663248 0.0243722013 1.040482e-02 2.975834e-02 6 109796852 109797302 451 + 0.000 0.429 15.125
ENSG00000112367 E080 0.0000000       6 109825063 109825087 25 +      
ENSG00000112367 E081 73.9861754 0.0093698213 1.007378e-04 5.252923e-04 6 109825088 109825334 247 + 1.758 2.000 0.813
ENSG00000112367 E082 20.5832511 0.0190647360 1.221471e-02 3.404651e-02 6 109825335 109826521 1187 + 1.212 1.463 0.875
ENSG00000112367 E083 1.1134841 0.0120631464 7.618742e-01 8.456307e-01 6 109826522 109826696 175 + 0.301 0.356 0.342
ENSG00000112367 E084 2.0754434 0.0591155703 1.667512e-02 4.422336e-02 6 109826697 109828495 1799 + 0.629 0.153 -2.949
ENSG00000112367 E085 1.1102619 0.0123014055 2.934431e-01 4.345020e-01 6 109828496 109829119 624 + 0.243 0.430 1.171
ENSG00000112367 E086 0.0000000       6 109877822 109878098 277 +