ENSG00000112339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367826 ENSG00000112339 HEK293_OSMI2_2hA HEK293_TMG_2hB HBS1L protein_coding protein_coding 48.14244 15.12344 87.19138 0.6687941 1.52053 2.526611 10.738926 6.766587 16.851293 1.0519058 0.2831479 1.315084 0.28231667 0.44783333 0.19330000 -0.25453333 2.465926e-03 2.051575e-11 FALSE TRUE
ENST00000524715 ENSG00000112339 HEK293_OSMI2_2hA HEK293_TMG_2hB HBS1L protein_coding protein_coding 48.14244 15.12344 87.19138 0.6687941 1.52053 2.526611 1.681250 0.000000 4.721323 0.0000000 0.8282614 8.886100 0.02117083 0.00000000 0.05383333 0.05383333 2.051575e-11 2.051575e-11 FALSE FALSE
ENST00000533274 ENSG00000112339 HEK293_OSMI2_2hA HEK293_TMG_2hB HBS1L protein_coding protein_coding 48.14244 15.12344 87.19138 0.6687941 1.52053 2.526611 8.500467 1.075836 16.145021 0.6849815 1.0870167 3.895104 0.15187917 0.07036667 0.18536667 0.11500000 4.163921e-01 2.051575e-11 FALSE TRUE
MSTRG.28992.10 ENSG00000112339 HEK293_OSMI2_2hA HEK293_TMG_2hB HBS1L protein_coding   48.14244 15.12344 87.19138 0.6687941 1.52053 2.526611 13.290886 1.693665 25.632598 0.2018971 0.8001998 3.911829 0.23198750 0.11240000 0.29386667 0.18146667 1.225490e-10 2.051575e-11 TRUE TRUE
MSTRG.28992.2 ENSG00000112339 HEK293_OSMI2_2hA HEK293_TMG_2hB HBS1L protein_coding   48.14244 15.12344 87.19138 0.6687941 1.52053 2.526611 8.725938 4.650356 14.834316 0.2533615 1.7785757 1.671399 0.21508333 0.30766667 0.16970000 -0.13796667 7.054840e-04 2.051575e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112339 E001 19.0661951 0.0010428057 3.328729e-02 7.836194e-02 6 134960378 134964628 4251 - 1.253 1.058 -0.697
ENSG00000112339 E002 1.1145283 0.0235119517 2.979816e-02 7.156567e-02 6 134964629 134964630 2 - 0.163 0.577 2.602
ENSG00000112339 E003 1.1145283 0.0235119517 2.979816e-02 7.156567e-02 6 134964631 134964632 2 - 0.163 0.577 2.602
ENSG00000112339 E004 79.9737508 0.0087672213 4.230106e-23 3.792621e-21 6 134964633 134964768 136 - 1.599 2.230 2.125
ENSG00000112339 E005 119.9126362 0.0058022484 6.436447e-32 1.232661e-29 6 134964769 134964841 73 - 1.782 2.394 2.050
ENSG00000112339 E006 192.7262946 0.0061682673 3.007465e-13 7.979766e-12 6 134964842 134964950 109 - 2.093 2.465 1.241
ENSG00000112339 E007 293.2198615 0.0029681173 1.781283e-11 3.556315e-10 6 134964951 134965148 198 - 2.312 2.575 0.876
ENSG00000112339 E008 299.4451992 0.0062457499 1.457288e-03 5.498155e-03 6 134965149 134965290 142 - 2.346 2.520 0.580
ENSG00000112339 E009 327.4309177 0.0043812332 5.422745e-03 1.707679e-02 6 134966329 134966473 145 - 2.395 2.536 0.470
ENSG00000112339 E010 284.8302614 0.0001996851 1.052595e-02 3.003812e-02 6 134969238 134969338 101 - 2.348 2.442 0.315
ENSG00000112339 E011 281.0794202 0.0001818611 6.856346e-03 2.085236e-02 6 134978679 134978787 109 - 2.341 2.439 0.327
ENSG00000112339 E012 286.0927822 0.0001421214 2.760425e-01 4.154486e-01 6 134979178 134979268 91 - 2.357 2.414 0.190
ENSG00000112339 E013 4.0725605 0.0047424462 6.840894e-01 7.871401e-01 6 134982293 134982457 165 - 0.623 0.713 0.382
ENSG00000112339 E014 288.1323390 0.0001601347 2.456789e-01 3.808393e-01 6 134982458 134982562 105 - 2.360 2.419 0.196
ENSG00000112339 E015 1.8927174 0.0081686681 2.461188e-01 3.813900e-01 6 134982563 134983573 1011 - 0.346 0.578 1.190
ENSG00000112339 E016 230.1383150 0.0045888261 2.701181e-01 4.087011e-01 6 134985341 134985409 69 - 2.259 2.332 0.241
ENSG00000112339 E017 277.7214705 0.0001817995 8.939707e-01 9.361979e-01 6 134986066 134986183 118 - 2.350 2.383 0.109
ENSG00000112339 E018 245.0406000 0.0001757589 2.726295e-01 4.115807e-01 6 134986736 134986810 75 - 2.302 2.301 -0.006
ENSG00000112339 E019 155.3321474 0.0002371188 3.416974e-02 8.008500e-02 6 134987645 134987653 9 - 2.114 2.066 -0.160
ENSG00000112339 E020 360.0390688 0.0002568905 3.771633e-02 8.680158e-02 6 134987654 134987791 138 - 2.472 2.451 -0.071
ENSG00000112339 E021 306.7674642 0.0002136525 2.002367e-02 5.153828e-02 6 134993758 134993875 118 - 2.404 2.373 -0.104
ENSG00000112339 E022 201.0497803 0.0010603389 2.492120e-02 6.171161e-02 6 134996777 134996821 45 - 2.225 2.174 -0.171
ENSG00000112339 E023 301.0909976 0.0003951699 2.193902e-02 5.554966e-02 6 134996822 134996942 121 - 2.397 2.364 -0.110
ENSG00000112339 E024 178.5474714 0.0001998953 1.414234e-01 2.499743e-01 6 134997397 134997421 25 - 2.170 2.151 -0.066
ENSG00000112339 E025 430.8561171 0.0001268518 8.917636e-05 4.711546e-04 6 134997422 134997656 235 - 2.557 2.502 -0.186
ENSG00000112339 E026 0.1451727 0.0432628624 1.000000e+00   6 135002621 135002733 113 - 0.062 0.000 -9.038
ENSG00000112339 E027 212.9341372 0.0004631221 8.370731e-08 8.629477e-07 6 135002734 135002781 48 - 2.269 2.117 -0.507
ENSG00000112339 E028 192.4869127 0.0001972676 2.848223e-09 3.882203e-08 6 135002782 135002814 33 - 2.229 2.053 -0.591
ENSG00000112339 E029 185.7782865 0.0002170883 2.199158e-07 2.091381e-06 6 135002815 135002833 19 - 2.210 2.058 -0.508
ENSG00000112339 E030 154.3923622 0.0011846137 8.571775e-04 3.462984e-03 6 135002834 135002842 9 - 2.123 2.017 -0.357
ENSG00000112339 E031 0.1817044 0.0427745907 9.710440e-02   6 135026854 135026863 10 - 0.000 0.229 13.146
ENSG00000112339 E032 0.2903454 0.3261219389 1.000000e+00   6 135026864 135027066 203 - 0.115 0.000 -10.035
ENSG00000112339 E033 0.2903454 0.3261219389 1.000000e+00   6 135027067 135027196 130 - 0.115 0.000 -10.035
ENSG00000112339 E034 22.6801478 0.0018079637 4.376936e-01 5.796070e-01 6 135035857 135036695 839 - 1.271 1.366 0.332
ENSG00000112339 E035 14.2758339 0.0012531607 3.237199e-01 4.670457e-01 6 135036696 135036794 99 - 1.115 1.031 -0.306
ENSG00000112339 E036 66.1570128 0.0151246502 3.683010e-04 1.651679e-03 6 135036795 135037810 1016 - 1.785 1.508 -0.941
ENSG00000112339 E037 16.7989684 0.0929650263 7.227718e-02 1.471257e-01 6 135037811 135037848 38 - 1.211 0.910 -1.097
ENSG00000112339 E038 24.6529439 0.0501006591 5.919927e-03 1.839751e-02 6 135037849 135038026 178 - 1.380 0.975 -1.445
ENSG00000112339 E039 0.4355181 0.5907074705 1.000000e+00 1.000000e+00 6 135038027 135038031 5 - 0.162 0.000 -10.615
ENSG00000112339 E040 392.5518275 0.0001842227 1.858325e-14 5.881291e-13 6 135039573 135039767 195 - 2.534 2.378 -0.521
ENSG00000112339 E041 263.5384473 0.0002363661 3.057409e-15 1.086303e-13 6 135042001 135042126 126 - 2.370 2.159 -0.704
ENSG00000112339 E042 177.1319675 0.0029282183 1.047486e-06 8.654675e-06 6 135050582 135050647 66 - 2.196 2.005 -0.640
ENSG00000112339 E043 218.4223870 0.0011323152 1.458960e-12 3.478862e-11 6 135054649 135054884 236 - 2.292 2.058 -0.782
ENSG00000112339 E044 0.0000000       6 135102928 135103056 129 -