ENSG00000112335

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000230085 ENSG00000112335 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX3 protein_coding protein_coding 76.07261 61.26183 96.06587 7.864977 2.681603 0.6489501 33.620861 31.409186 47.820557 4.5690540 2.5825035 0.6062868 0.44240833 0.51186667 0.49743333 -0.01443333 0.91456097 0.01221107 FALSE  
ENST00000349379 ENSG00000112335 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX3 protein_coding protein_coding 76.07261 61.26183 96.06587 7.864977 2.681603 0.6489501 4.311673 2.943775 8.115711 0.3441709 0.5422474 1.4599341 0.05464167 0.04876667 0.08450000 0.03573333 0.01221107 0.01221107 FALSE  
ENST00000426155 ENSG00000112335 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX3 protein_coding protein_coding 76.07261 61.26183 96.06587 7.864977 2.681603 0.6489501 26.065942 23.851066 30.612596 4.4441854 1.4082848 0.3599381 0.35640417 0.38403333 0.31903333 -0.06500000 0.23798474 0.01221107 FALSE  
MSTRG.28732.5 ENSG00000112335 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX3 protein_coding   76.07261 61.26183 96.06587 7.864977 2.681603 0.6489501 4.687933 1.453584 7.544184 0.4950626 0.6015266 2.3677704 0.05833750 0.02583333 0.07843333 0.05260000 0.03525469 0.01221107 FALSE  
MSTRG.28732.6 ENSG00000112335 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX3 protein_coding   76.07261 61.26183 96.06587 7.864977 2.681603 0.6489501 6.766274 1.477689 1.137451 1.4776894 1.1374506 -0.3746414 0.08150833 0.02716667 0.01196667 -0.01520000 0.98102847 0.01221107 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112335 E001 40.5199346 0.0090271875 6.064580e-03 1.877990e-02 6 108211222 108211512 291 - 1.525 1.712 0.635
ENSG00000112335 E002 508.3063165 0.0009481005 5.883916e-07 5.135875e-06 6 108211513 108211728 216 - 2.664 2.760 0.319
ENSG00000112335 E003 1212.9431487 0.0027927452 1.355449e-05 8.733911e-05 6 108211729 108212004 276 - 3.041 3.130 0.293
ENSG00000112335 E004 994.5799564 0.0001996934 2.000018e-08 2.332107e-07 6 108212005 108212254 250 - 2.974 3.033 0.197
ENSG00000112335 E005 549.3307776 0.0001212541 9.239174e-01 9.560904e-01 6 108214498 108214622 125 - 2.747 2.744 -0.009
ENSG00000112335 E006 0.4396707 0.0280360033 1.461550e-01 2.564545e-01 6 108222234 108222320 87 - 0.267 0.000 -11.191
ENSG00000112335 E007 452.7536888 0.0002290274 1.429459e-03 5.405214e-03 6 108222950 108223045 96 - 2.688 2.629 -0.198
ENSG00000112335 E008 0.1451727 0.0431826174 6.598765e-01   6 108238013 108238068 56 - 0.108 0.000 -9.606
ENSG00000112335 E009 420.6706371 0.0045377031 3.541873e-05 2.068043e-04 6 108260760 108260825 66 - 2.694 2.533 -0.536
ENSG00000112335 E010 442.3927510 0.0052084765 2.462679e-09 3.395045e-08 6 108260826 108260954 129 - 2.745 2.505 -0.797
ENSG00000112335 E011 215.9995069 0.0063705808 6.012631e-09 7.738807e-08 6 108260955 108261107 153 - 2.449 2.165 -0.949
ENSG00000112335 E012 32.9065119 0.0034655406 7.198507e-04 2.970035e-03 6 108261108 108261279 172 - 1.629 1.391 -0.814