ENSG00000112320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317357 ENSG00000112320 HEK293_OSMI2_2hA HEK293_TMG_2hB SOBP protein_coding protein_coding 5.041759 4.698893 7.584747 0.52035 0.221342 0.6896141 1.3444149 1.1938206 1.5213515 0.24025310 0.01674536 0.3471851 0.28448750 0.24870000 0.20093333 -0.04776667 4.859696e-01 2.579212e-06 FALSE TRUE
ENST00000477448 ENSG00000112320 HEK293_OSMI2_2hA HEK293_TMG_2hB SOBP protein_coding retained_intron 5.041759 4.698893 7.584747 0.52035 0.221342 0.6896141 0.6531959 0.3701594 1.7936353 0.06568916 0.19179099 2.2462311 0.11270833 0.08360000 0.23766667 0.15406667 1.272889e-02 2.579212e-06 FALSE TRUE
ENST00000494935 ENSG00000112320 HEK293_OSMI2_2hA HEK293_TMG_2hB SOBP protein_coding processed_transcript 5.041759 4.698893 7.584747 0.52035 0.221342 0.6896141 0.5477140 0.5582753 1.0857082 0.16970272 0.26415395 0.9472018 0.10138750 0.11860000 0.14533333 0.02673333 8.608082e-01 2.579212e-06 FALSE FALSE
MSTRG.28729.3 ENSG00000112320 HEK293_OSMI2_2hA HEK293_TMG_2hB SOBP protein_coding   5.041759 4.698893 7.584747 0.52035 0.221342 0.6896141 0.3142276 0.2150332 0.5527348 0.10835142 0.07826454 1.3223173 0.06002083 0.04923333 0.07360000 0.02436667 7.006641e-01 2.579212e-06 FALSE TRUE
MSTRG.28729.4 ENSG00000112320 HEK293_OSMI2_2hA HEK293_TMG_2hB SOBP protein_coding   5.041759 4.698893 7.584747 0.52035 0.221342 0.6896141 0.8973406 1.5260205 0.5244679 0.13653005 0.03037266 -1.5230222 0.20490833 0.33730000 0.06903333 -0.26826667 2.579212e-06 2.579212e-06 FALSE TRUE
MSTRG.28729.5 ENSG00000112320 HEK293_OSMI2_2hA HEK293_TMG_2hB SOBP protein_coding   5.041759 4.698893 7.584747 0.52035 0.221342 0.6896141 1.2684064 0.8355835 2.0956910 0.42702296 0.65249452 1.3162745 0.23372083 0.16260000 0.27200000 0.10940000 7.327525e-01 2.579212e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112320 E001 0.6966155 0.0172671820 3.156588e-01 4.584249e-01 6 107490106 107490116 11 + 0.118 0.305 1.708
ENSG00000112320 E002 6.9619927 0.0123084741 1.530182e-04 7.604825e-04 6 107490117 107490201 85 + 1.076 0.609 -1.833
ENSG00000112320 E003 18.4414831 0.0145996470 3.833057e-06 2.800359e-05 6 107490202 107490452 251 + 1.454 1.038 -1.470
ENSG00000112320 E004 26.8051477 0.0134045424 5.201946e-04 2.235439e-03 6 107490453 107490603 151 + 1.563 1.313 -0.863
ENSG00000112320 E005 36.9917341 0.0043628749 2.108628e-05 1.300792e-04 6 107490604 107490712 109 + 1.688 1.459 -0.779
ENSG00000112320 E006 52.8354430 0.0004922675 2.227934e-03 7.930022e-03 6 107503657 107503795 139 + 1.780 1.677 -0.349
ENSG00000112320 E007 74.8480372 0.0005974665 2.078428e-03 7.467182e-03 6 107506242 107506427 186 + 1.918 1.836 -0.274
ENSG00000112320 E008 0.1451727 0.0431108582 4.858112e-01   6 107513958 107515073 1116 + 0.118 0.000 -8.513
ENSG00000112320 E009 4.5683548 0.0114738306 7.383663e-02 1.496489e-01 6 107529459 107529611 153 + 0.860 0.642 -0.882
ENSG00000112320 E010 48.4386491 0.0119248582 1.305001e-01 2.348584e-01 6 107533459 107533610 152 + 1.720 1.657 -0.214
ENSG00000112320 E011 11.1593603 0.0018486971 8.428113e-04 3.411565e-03 6 107557837 107558287 451 + 1.220 0.928 -1.063
ENSG00000112320 E012 22.5942887 0.0011744462 2.213120e-01 3.520010e-01 6 107587080 107587175 96 + 1.393 1.344 -0.170
ENSG00000112320 E013 1.6973972 0.0131068431 3.093123e-02 7.377988e-02 6 107627386 107627509 124 + 0.581 0.225 -2.047
ENSG00000112320 E014 97.8539273 0.0026639754 4.663042e-01 6.058689e-01 6 107633514 107634989 1476 + 1.949 2.020 0.237
ENSG00000112320 E015 44.7013717 0.0077405375 5.841356e-01 7.081282e-01 6 107634990 107635469 480 + 1.615 1.691 0.257
ENSG00000112320 E016 4.1255569 0.0039564660 1.071637e-01 2.013533e-01 6 107636225 107636316 92 + 0.543 0.809 1.123
ENSG00000112320 E017 214.2472325 0.0049834489 1.345722e-17 6.501989e-16 6 107658207 107661306 3100 + 2.138 2.454 1.056