ENSG00000112308

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378102 ENSG00000112308 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf62 protein_coding protein_coding 77.93293 58.23953 93.92097 2.787481 4.190311 0.6893545 25.97322 13.114617 32.98177 0.4743794 1.765438 1.3298308 0.3202542 0.2258333 0.3509333 0.125100000 1.638625e-08 1.638625e-08 FALSE TRUE
ENST00000378119 ENSG00000112308 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf62 protein_coding protein_coding 77.93293 58.23953 93.92097 2.787481 4.190311 0.6893545 40.32094 36.263160 45.47000 2.6464626 1.629305 0.3263298 0.5302208 0.6214333 0.4847333 -0.136700000 5.355716e-04 1.638625e-08 FALSE TRUE
MSTRG.27734.5 ENSG00000112308 HEK293_OSMI2_2hA HEK293_TMG_2hB C6orf62 protein_coding   77.93293 58.23953 93.92097 2.787481 4.190311 0.6893545 9.77998 8.169444 12.44128 0.4123237 1.024661 0.6062194 0.1273000 0.1403000 0.1322333 -0.008066667 8.095678e-01 1.638625e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112308 E001 216.50541 0.0035872381 1.963072e-09 2.752966e-08 6 24704861 24705074 214 - 2.209 2.444 0.786
ENSG00000112308 E002 1353.80237 0.0003309999 6.823297e-30 1.141920e-27 6 24705075 24706071 997 - 3.066 3.194 0.427
ENSG00000112308 E003 185.04443 0.0017092573 1.088481e-01 2.038387e-01 6 24706072 24706095 24 - 2.242 2.305 0.208
ENSG00000112308 E004 504.91742 0.0001523584 7.420630e-03 2.231277e-02 6 24706096 24706262 167 - 2.724 2.691 -0.111
ENSG00000112308 E005 468.51611 0.0001707664 6.707751e-06 4.639177e-05 6 24708777 24708911 135 - 2.705 2.638 -0.220
ENSG00000112308 E006 54.06707 0.0006020333 2.206584e-15 7.970080e-14 6 24710354 24710494 141 - 1.503 1.907 1.371
ENSG00000112308 E007 51.39085 0.0007148046 3.980540e-15 1.390049e-13 6 24710495 24710589 95 - 1.469 1.883 1.406
ENSG00000112308 E008 483.79756 0.0001464206 1.071703e-03 4.206760e-03 6 24714318 24714440 123 - 2.709 2.665 -0.147
ENSG00000112308 E009 549.48211 0.0010584948 2.644044e-05 1.593669e-04 6 24716148 24716321 174 - 2.780 2.700 -0.266
ENSG00000112308 E010 185.32504 0.0002218913 2.012285e-05 1.247207e-04 6 24716322 24716324 3 - 2.320 2.216 -0.346
ENSG00000112308 E011 975.21380 0.0001227722 1.351222e-16 5.721613e-15 6 24718540 24719154 615 - 3.031 2.947 -0.279
ENSG00000112308 E012 141.46765 0.0064622392 6.967736e-04 2.887365e-03 6 24719860 24719998 139 - 2.228 2.063 -0.551