ENSG00000112290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392586 ENSG00000112290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASF1 protein_coding protein_coding 37.22322 32.03873 46.00781 1.519797 0.9107225 0.5219252 1.733280 2.161802 1.579021 1.1265430 0.9878263 -0.4507545 0.05025000 0.06446667 0.03516667 -0.029300000 9.168621e-01 3.11747e-19 FALSE TRUE
ENST00000392587 ENSG00000112290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASF1 protein_coding protein_coding 37.22322 32.03873 46.00781 1.519797 0.9107225 0.5219252 23.636206 24.751642 27.026813 1.1036648 1.2494148 0.1268181 0.65538750 0.77290000 0.58683333 -0.186066667 2.483567e-09 3.11747e-19 FALSE TRUE
ENST00000392588 ENSG00000112290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASF1 protein_coding protein_coding 37.22322 32.03873 46.00781 1.519797 0.9107225 0.5219252 2.014163 1.557142 2.012894 0.1693728 1.0068298 0.3682853 0.05264167 0.04893333 0.04290000 -0.006033333 8.479393e-01 3.11747e-19 FALSE TRUE
MSTRG.28774.6 ENSG00000112290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASF1 protein_coding   37.22322 32.03873 46.00781 1.519797 0.9107225 0.5219252 2.644354 0.000000 4.197729 0.0000000 0.6444817 8.7168981 0.06120417 0.00000000 0.09183333 0.091833333 3.117470e-19 3.11747e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112290 E001 394.635089 0.0059178778 6.533324e-10 1.003257e-08 6 110099819 110100129 311 - 2.453 2.698 0.817
ENSG00000112290 E002 221.887123 0.0003679180 3.296428e-16 1.329003e-14 6 110100130 110100144 15 - 2.232 2.432 0.665
ENSG00000112290 E003 291.980478 0.0026962715 2.769330e-09 3.785010e-08 6 110100145 110100194 50 - 2.358 2.545 0.624
ENSG00000112290 E004 245.557215 0.0022824709 5.744439e-08 6.109397e-07 6 110100195 110100247 53 - 2.294 2.463 0.563
ENSG00000112290 E005 179.860315 0.0006701236 6.965926e-11 1.262242e-09 6 110100248 110100254 7 - 2.151 2.333 0.610
ENSG00000112290 E006 195.516497 0.0002226884 1.158837e-11 2.387063e-10 6 110100255 110100266 12 - 2.194 2.363 0.567
ENSG00000112290 E007 185.970802 0.0002420428 2.632849e-11 5.119422e-10 6 110100267 110100268 2 - 2.170 2.342 0.573
ENSG00000112290 E008 184.407489 0.0003092039 5.152851e-12 1.124905e-10 6 110100269 110100269 1 - 2.160 2.341 0.605
ENSG00000112290 E009 238.019469 0.0013112219 2.761341e-12 6.309586e-11 6 110100270 110100315 46 - 2.263 2.459 0.653
ENSG00000112290 E010 670.289884 0.0001338898 2.962290e-14 9.091153e-13 6 110100316 110100679 364 - 2.771 2.870 0.329
ENSG00000112290 E011 867.797850 0.0022674359 1.312658e-01 2.359071e-01 6 110101588 110102216 629 - 2.958 2.920 -0.124
ENSG00000112290 E012 346.417829 0.0011099975 2.601699e-04 1.217509e-03 6 110103378 110103557 180 - 2.584 2.490 -0.315
ENSG00000112290 E013 375.038405 0.0006775760 4.631916e-08 5.029533e-07 6 110105407 110105576 170 - 2.633 2.509 -0.414
ENSG00000112290 E014 152.394975 0.0005101255 2.709429e-04 1.261534e-03 6 110105577 110105579 3 - 2.241 2.125 -0.389
ENSG00000112290 E015 292.777801 0.0002429372 4.167402e-12 9.230700e-11 6 110107077 110107194 118 - 2.540 2.385 -0.519
ENSG00000112290 E016 347.464132 0.0011543044 2.019762e-15 7.327421e-14 6 110108528 110108681 154 - 2.633 2.430 -0.675
ENSG00000112290 E017 312.278399 0.0017607377 5.894462e-15 2.007349e-13 6 110113326 110113460 135 - 2.598 2.371 -0.755
ENSG00000112290 E018 287.803603 0.0009279844 7.872640e-25 8.498279e-23 6 110127469 110127629 161 - 2.578 2.310 -0.893
ENSG00000112290 E019 34.673375 0.0242042745 5.650014e-04 2.402880e-03 6 110160635 110160732 98 - 1.697 1.356 -1.172
ENSG00000112290 E020 7.463636 0.0079052325 5.176580e-02 1.123019e-01 6 110177147 110177186 40 - 1.035 0.791 -0.926
ENSG00000112290 E021 58.392013 0.0033340714 2.527538e-11 4.929324e-10 6 110178598 110178742 145 - 1.929 1.554 -1.270
ENSG00000112290 E022 106.858028 0.0175492027 3.831822e-05 2.218943e-04 6 110179439 110179466 28 - 2.165 1.856 -1.036
ENSG00000112290 E023 143.602606 0.0233585933 1.721240e-04 8.443766e-04 6 110179467 110179840 374 - 2.290 1.986 -1.019
ENSG00000112290 E024 19.564748 0.0009101041 2.343442e-07 2.217019e-06 6 110179841 110180024 184 - 1.480 1.055 -1.498