ENSG00000112282

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354577 ENSG00000112282 HEK293_OSMI2_2hA HEK293_TMG_2hB MED23 protein_coding protein_coding 14.94528 4.926891 22.65655 0.3581916 0.8929462 2.19889 0.7485689 0.41872709 1.404598 0.33367175 0.1235075 1.722260 0.07906667 0.07650000 0.06243333 -0.014066667 8.904786e-01 7.75517e-07 FALSE TRUE
ENST00000368068 ENSG00000112282 HEK293_OSMI2_2hA HEK293_TMG_2hB MED23 protein_coding protein_coding 14.94528 4.926891 22.65655 0.3581916 0.8929462 2.19889 4.8080134 2.75383203 6.507207 0.24588951 0.2402882 1.237584 0.40547500 0.55846667 0.28886667 -0.269600000 7.755170e-07 7.75517e-07 FALSE TRUE
ENST00000479213 ENSG00000112282 HEK293_OSMI2_2hA HEK293_TMG_2hB MED23 protein_coding processed_transcript 14.94528 4.926891 22.65655 0.3581916 0.8929462 2.19889 0.7366182 0.33723840 1.102230 0.10764456 0.1134556 1.679457 0.06215417 0.06623333 0.04840000 -0.017833333 6.081255e-01 7.75517e-07 FALSE TRUE
ENST00000484885 ENSG00000112282 HEK293_OSMI2_2hA HEK293_TMG_2hB MED23 protein_coding processed_transcript 14.94528 4.926891 22.65655 0.3581916 0.8929462 2.19889 1.6886777 0.48622287 2.419627 0.08208142 0.2720154 2.291675 0.11598333 0.09986667 0.10663333 0.006766667 9.277663e-01 7.75517e-07   FALSE
MSTRG.28962.2 ENSG00000112282 HEK293_OSMI2_2hA HEK293_TMG_2hB MED23 protein_coding   14.94528 4.926891 22.65655 0.3581916 0.8929462 2.19889 2.0432217 0.79561427 2.871834 0.44289373 0.3154610 1.838826 0.12545833 0.17193333 0.12783333 -0.044100000 9.761801e-01 7.75517e-07 FALSE TRUE
MSTRG.28962.6 ENSG00000112282 HEK293_OSMI2_2hA HEK293_TMG_2hB MED23 protein_coding   14.94528 4.926891 22.65655 0.3581916 0.8929462 2.19889 3.6135152 0.04986885 6.821677 0.04986885 0.8516222 6.834291 0.15361667 0.01133333 0.30013333 0.288800000 5.071869e-06 7.75517e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112282 E001 1.3703297 0.0108866068 2.774023e-02 6.749857e-02 6 131573966 131573982 17 - 0.222 0.619 2.243
ENSG00000112282 E002 24.0790502 0.0016529515 8.110909e-21 5.727124e-19 6 131573983 131574295 313 - 1.061 1.744 2.371
ENSG00000112282 E003 0.5879639 0.0210697853 8.640316e-01 9.163328e-01 6 131586732 131586737 6 - 0.176 0.213 0.338
ENSG00000112282 E004 0.8824620 0.2367246377 8.782297e-01 9.258011e-01 6 131586738 131586748 11 - 0.263 0.211 -0.413
ENSG00000112282 E005 15.4153391 0.0650384441 7.972648e-07 6.762152e-06 6 131586749 131586937 189 - 0.824 1.590 2.741
ENSG00000112282 E006 56.6920265 0.0082062239 1.596568e-19 9.663417e-18 6 131586938 131587202 265 - 1.471 2.062 2.002
ENSG00000112282 E007 27.8108583 0.0066646117 2.188422e-18 1.155013e-16 6 131587203 131587244 42 - 1.120 1.794 2.328
ENSG00000112282 E008 145.0401332 0.0029207891 3.815419e-09 5.078120e-08 6 131587245 131587708 464 - 2.027 2.274 0.827
ENSG00000112282 E009 133.3590584 0.0002685228 1.239920e-07 1.237288e-06 6 131587709 131587842 134 - 2.012 2.201 0.631
ENSG00000112282 E010 55.6961030 0.0004435826 9.519541e-04 3.794497e-03 6 131587843 131587846 4 - 1.639 1.821 0.616
ENSG00000112282 E011 0.1482932 0.0405979433 1.176031e-01   6 131589461 131589464 4 - 0.000 0.213 11.337
ENSG00000112282 E012 123.8411785 0.0002694168 1.250172e-07 1.246731e-06 6 131589465 131589596 132 - 1.976 2.170 0.653
ENSG00000112282 E013 110.2967653 0.0003840503 1.126926e-06 9.254526e-06 6 131590322 131590409 88 - 1.925 2.117 0.644
ENSG00000112282 E014 67.2689392 0.0003767596 3.121334e-03 1.062316e-02 6 131590410 131590442 33 - 1.728 1.880 0.512
ENSG00000112282 E015 164.6730055 0.0002252230 2.083258e-03 7.481696e-03 6 131591313 131591527 215 - 2.126 2.233 0.355
ENSG00000112282 E016 18.8800153 0.0036814449 5.347587e-01 6.667634e-01 6 131591528 131591984 457 - 1.244 1.193 -0.181
ENSG00000112282 E017 83.6105521 0.0003355414 2.082354e-02 5.321962e-02 6 131592388 131592460 73 - 1.836 1.947 0.374
ENSG00000112282 E018 18.2851392 0.0026554321 6.627686e-03 2.025742e-02 6 131592461 131593005 545 - 1.276 0.994 -1.010
ENSG00000112282 E019 117.0825393 0.0003188468 4.016050e-01 5.452991e-01 6 131593006 131593171 166 - 1.999 2.041 0.143
ENSG00000112282 E020 131.9931528 0.0002473198 2.087383e-01 3.369906e-01 6 131594099 131594335 237 - 2.045 2.100 0.184
ENSG00000112282 E021 114.9202379 0.0003581190 1.175374e-01 2.164196e-01 6 131595947 131596163 217 - 1.979 2.049 0.234
ENSG00000112282 E022 1.8561737 0.0725406377 2.780891e-01 4.177124e-01 6 131596164 131596517 354 - 0.453 0.214 -1.529
ENSG00000112282 E023 92.5508469 0.0003471964 5.682596e-01 6.949479e-01 6 131596518 131596688 171 - 1.908 1.894 -0.049
ENSG00000112282 E024 0.6611159 0.0191428666 8.557639e-01 9.108059e-01 6 131598251 131598286 36 - 0.176 0.214 0.342
ENSG00000112282 E025 90.8509527 0.0003547479 8.314485e-01 8.943540e-01 6 131598287 131598467 181 - 1.899 1.901 0.005
ENSG00000112282 E026 99.5544153 0.0025592823 8.114796e-02 1.613311e-01 6 131598556 131598761 206 - 1.955 1.879 -0.255
ENSG00000112282 E027 79.9120314 0.0010655701 1.374790e-03 5.224672e-03 6 131600038 131600162 125 - 1.874 1.719 -0.524
ENSG00000112282 E028 75.1500066 0.0006325432 4.681600e-06 3.354063e-05 6 131602218 131602298 81 - 1.862 1.625 -0.801
ENSG00000112282 E029 72.6691206 0.0015376138 7.277467e-05 3.935191e-04 6 131602299 131602381 83 - 1.845 1.632 -0.722
ENSG00000112282 E030 104.1100202 0.0003126485 4.030301e-05 2.321037e-04 6 131603030 131603204 175 - 1.991 1.821 -0.572
ENSG00000112282 E031 99.2636064 0.0003188618 7.339240e-05 3.964973e-04 6 131604178 131604320 143 - 1.969 1.800 -0.567
ENSG00000112282 E032 121.8778854 0.0002872196 6.784357e-05 3.697360e-04 6 131605240 131605485 246 - 2.055 1.904 -0.504
ENSG00000112282 E033 84.7956280 0.0003643238 6.762882e-03 2.060747e-02 6 131606479 131606624 146 - 1.892 1.773 -0.400
ENSG00000112282 E034 71.3282674 0.0008131062 7.406919e-04 3.045377e-03 6 131607928 131608071 144 - 1.829 1.657 -0.583
ENSG00000112282 E035 39.9768532 0.0005129646 3.114668e-02 7.418555e-02 6 131610046 131610087 42 - 1.579 1.441 -0.471
ENSG00000112282 E036 59.5845409 0.0005751486 1.838493e-01 3.060499e-01 6 131610088 131610246 159 - 1.732 1.669 -0.214
ENSG00000112282 E037 2.9602092 0.0050984795 1.831425e-01 3.051361e-01 6 131615324 131615341 18 - 0.603 0.356 -1.246
ENSG00000112282 E038 60.6290197 0.0004248475 2.857723e-03 9.846623e-03 6 131615907 131616002 96 - 1.758 1.599 -0.541
ENSG00000112282 E039 78.8906012 0.0003819113 5.387402e-06 3.806890e-05 6 131618407 131618519 113 - 1.882 1.657 -0.760
ENSG00000112282 E040 63.5716221 0.0054573312 1.131495e-03 4.409577e-03 6 131619827 131619896 70 - 1.787 1.577 -0.715
ENSG00000112282 E041 76.5658027 0.0004257887 2.768661e-06 2.088626e-05 6 131620628 131620729 102 - 1.870 1.632 -0.806
ENSG00000112282 E042 65.1457573 0.0018536436 1.148323e-05 7.526511e-05 6 131621881 131621979 99 - 1.805 1.547 -0.876
ENSG00000112282 E043 76.7924723 0.0004231022 4.049095e-06 2.940954e-05 6 131623351 131623462 112 - 1.871 1.638 -0.787
ENSG00000112282 E044 70.4530560 0.0146811542 1.829414e-03 6.693905e-03 6 131624865 131624989 125 - 1.835 1.581 -0.862
ENSG00000112282 E045 0.5212538 0.0202346763 9.192891e-02 1.781143e-01 6 131626961 131627395 435 - 0.067 0.356 2.925
ENSG00000112282 E046 66.7255429 0.0003851735 4.635109e-04 2.020124e-03 6 131627396 131627483 88 - 1.801 1.619 -0.618
ENSG00000112282 E047 51.8038223 0.0004293226 4.710763e-04 2.049458e-03 6 131627641 131627672 32 - 1.698 1.489 -0.716
ENSG00000112282 E048 66.0676759 0.0003684142 8.272840e-09 1.035518e-07 6 131628011 131628242 232 - 1.820 1.489 -1.128