ENSG00000112249

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369143 ENSG00000112249 HEK293_OSMI2_2hA HEK293_TMG_2hB ASCC3 protein_coding protein_coding 12.03094 3.471943 18.72538 0.6589506 0.4283113 2.427801 1.2152419 0.6308319 2.3935567 0.06696266 0.1117211 1.907153 0.1273958 0.1994333 0.1277 -0.07173333 5.228118e-01 1.650067e-05 FALSE FALSE
ENST00000369162 ENSG00000112249 HEK293_OSMI2_2hA HEK293_TMG_2hB ASCC3 protein_coding protein_coding 12.03094 3.471943 18.72538 0.6589506 0.4283113 2.427801 9.6983757 1.5847245 15.0793734 0.04497602 0.2562156 3.242154 0.6885500 0.4816667 0.8055 0.32383333 1.650067e-05 1.650067e-05 FALSE TRUE
ENST00000518006 ENSG00000112249 HEK293_OSMI2_2hA HEK293_TMG_2hB ASCC3 protein_coding retained_intron 12.03094 3.471943 18.72538 0.6589506 0.4283113 2.427801 0.9183366 1.2532497 0.6533048 0.67344984 0.3556184 -0.929396 0.1740917 0.3182333 0.0346 -0.28363333 1.125333e-01 1.650067e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112249 E001 140.2877995 0.0099564358 1.498121e-22 1.271001e-20 6 100508194 100509217 1024 - 1.836 2.437 2.016
ENSG00000112249 E002 152.4698419 0.0263708590 7.705752e-05 4.141249e-04 6 100509218 100509533 316 - 1.935 2.330 1.322
ENSG00000112249 E003 107.1223486 0.0023429495 6.405688e-10 9.853348e-09 6 100509932 100510107 176 - 1.798 2.139 1.144
ENSG00000112249 E004 0.8942170 0.0134894901 5.569638e-01 6.854962e-01 6 100510108 100510308 201 - 0.222 0.000 -10.561
ENSG00000112249 E005 114.3399185 0.0008598780 2.101635e-06 1.627155e-05 6 100512709 100512918 210 - 1.842 2.099 0.863
ENSG00000112249 E006 94.2678238 0.0009032482 8.012722e-02 1.597447e-01 6 100516180 100516327 148 - 1.783 1.918 0.456
ENSG00000112249 E007 92.9672304 0.0003944903 8.411341e-02 1.659917e-01 6 100517991 100518142 152 - 1.775 1.908 0.448
ENSG00000112249 E008 107.3081570 0.0003243153 2.831919e-03 9.769619e-03 6 100540163 100540387 225 - 1.829 2.012 0.617
ENSG00000112249 E009 76.6599757 0.0003674867 1.313523e-02 3.622063e-02 6 100589634 100589768 135 - 1.685 1.865 0.611
ENSG00000112249 E010 65.4252046 0.0036176481 1.155345e-01 2.136133e-01 6 100589948 100590059 112 - 1.624 1.771 0.500
ENSG00000112249 E011 54.6241162 0.0004166506 1.605887e-01 2.759093e-01 6 100601810 100601935 126 - 1.550 1.687 0.465
ENSG00000112249 E012 48.0400900 0.0009571248 3.331132e-01 4.767889e-01 6 100605568 100605700 133 - 1.499 1.613 0.387
ENSG00000112249 E013 60.1551782 0.0004048656 5.997440e-01 7.210882e-01 6 100606740 100606860 121 - 1.600 1.678 0.265
ENSG00000112249 E014 85.3653059 0.0003229404 9.992490e-01 1.000000e+00 6 100606951 100607088 138 - 1.755 1.798 0.148
ENSG00000112249 E015 86.9541268 0.0002989845 5.848545e-01 7.086732e-01 6 100625192 100625334 143 - 1.766 1.778 0.043
ENSG00000112249 E016 73.6439256 0.0003496418 4.556840e-01 5.961918e-01 6 100627590 100627710 121 - 1.684 1.771 0.297
ENSG00000112249 E017 77.1952750 0.0056331930 2.413664e-01 3.757840e-01 6 100627842 100627987 146 - 1.721 1.678 -0.145
ENSG00000112249 E018 60.3564055 0.0034586634 1.467798e-01 2.572929e-01 6 100629015 100629181 167 - 1.618 1.548 -0.238
ENSG00000112249 E019 55.2086300 0.0004490839 1.940967e-01 3.189245e-01 6 100631128 100631213 86 - 1.576 1.523 -0.181
ENSG00000112249 E020 93.5030299 0.0003302931 1.169818e-02 3.281486e-02 6 100638601 100638821 221 - 1.808 1.703 -0.354
ENSG00000112249 E021 72.7231852 0.0023782877 3.309651e-01 4.745352e-01 6 100642581 100642749 169 - 1.692 1.669 -0.076
ENSG00000112249 E022 57.8121428 0.0137036818 5.487427e-01 6.785704e-01 6 100644031 100644129 99 - 1.594 1.581 -0.047
ENSG00000112249 E023 63.5513473 0.0106814441 2.928273e-01 4.338445e-01 6 100646615 100646769 155 - 1.639 1.590 -0.167
ENSG00000112249 E024 40.6582671 0.0005806804 3.247807e-01 4.681864e-01 6 100647226 100647287 62 - 1.451 1.411 -0.139
ENSG00000112249 E025 69.9065283 0.0003433165 2.720892e-03 9.435217e-03 6 100647288 100647451 164 - 1.691 1.523 -0.570
ENSG00000112249 E026 72.8118347 0.0004023284 3.104546e-04 1.422156e-03 6 100650538 100650714 177 - 1.711 1.498 -0.726
ENSG00000112249 E027 56.6977452 0.0004508275 1.902800e-07 1.830869e-06 6 100651560 100651646 87 - 1.618 1.184 -1.503
ENSG00000112249 E028 80.6833483 0.0039515434 2.273753e-05 1.391240e-04 6 100652725 100652889 165 - 1.759 1.472 -0.980
ENSG00000112249 E029 71.2120213 0.0003586708 9.028089e-03 2.634866e-02 6 100655699 100655818 120 - 1.695 1.559 -0.461
ENSG00000112249 E030 97.2246675 0.0018249374 1.672054e-06 1.322557e-05 6 100661806 100662030 225 - 1.839 1.559 -0.949
ENSG00000112249 E031 71.5486928 0.0003624951 5.020525e-04 2.167506e-03 6 100662345 100662536 192 - 1.702 1.498 -0.697
ENSG00000112249 E032 51.9666028 0.0004446804 2.739475e-03 9.490973e-03 6 100679618 100679752 135 - 1.566 1.360 -0.710
ENSG00000112249 E033 0.1472490 0.0436988870 7.172386e-01   6 100715130 100715461 332 - 0.046 0.000 -7.976
ENSG00000112249 E034 44.4256259 0.0004812584 1.760591e-03 6.473336e-03 6 100715462 100715533 72 - 1.503 1.259 -0.846
ENSG00000112249 E035 71.9335813 0.0004364021 8.615691e-04 3.479020e-03 6 100718075 100718251 177 - 1.703 1.511 -0.655
ENSG00000112249 E036 66.3580630 0.0011007418 3.616212e-04 1.625257e-03 6 100725539 100725703 165 - 1.671 1.442 -0.784
ENSG00000112249 E037 57.1146890 0.0332416379 4.269285e-02 9.598216e-02 6 100766565 100766705 141 - 1.606 1.400 -0.708
ENSG00000112249 E038 74.1699825 0.0153395344 6.311349e-05 3.467206e-04 6 100767145 100767345 201 - 1.729 1.363 -1.252
ENSG00000112249 E039 62.9200195 0.0003929586 1.074290e-05 7.088049e-05 6 100798713 100798838 126 - 1.655 1.341 -1.076
ENSG00000112249 E040 54.3948915 0.0004585824 6.555837e-07 5.664950e-06 6 100799431 100799572 142 - 1.600 1.184 -1.442
ENSG00000112249 E041 62.8038910 0.0004401648 1.513251e-11 3.059562e-10 6 100800300 100800504 205 - 1.669 1.060 -2.126
ENSG00000112249 E042 46.6916173 0.0004709767 2.320220e-08 2.671439e-07 6 100805760 100805880 121 - 1.542 0.981 -1.980
ENSG00000112249 E043 0.2966881 0.0270351496 1.000000e+00   6 100848004 100848147 144 - 0.087 0.000 -8.976
ENSG00000112249 E044 68.3465789 0.0003849533 6.103061e-14 1.788133e-12 6 100848148 100848419 272 - 1.708 1.022 -2.394
ENSG00000112249 E045 62.4893728 0.0025113574 7.681381e-08 7.975964e-07 6 100848420 100848707 288 - 1.661 1.210 -1.558
ENSG00000112249 E046 114.0760526 0.0036415402 4.369965e-16 1.728344e-14 6 100856303 100859202 2900 - 1.797 2.228 1.448
ENSG00000112249 E047 57.4048706 0.0098656091 5.640643e-02 1.204332e-01 6 100864064 100864214 151 - 1.603 1.471 -0.454
ENSG00000112249 E048 48.4138501 0.0055781370 1.056991e-01 1.991604e-01 6 100867908 100868032 125 - 1.528 1.427 -0.349
ENSG00000112249 E049 22.0358165 0.0008330506 9.195563e-01 9.531914e-01 6 100868033 100868038 6 - 1.183 1.235 0.185
ENSG00000112249 E050 61.8206986 0.0003797196 2.103966e-02 5.367494e-02 6 100881061 100881372 312 - 1.635 1.511 -0.424