ENSG00000112237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518714 ENSG00000112237 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNC protein_coding protein_coding 42.3063 13.67541 77.01319 2.158847 3.32398 2.492654 3.576245 2.89512181 5.054543 0.41537179 0.226625 0.8018335 0.1276583 0.2127000 0.06570000 -0.1470000000 2.947669e-19 2.947669e-19 FALSE TRUE
ENST00000520429 ENSG00000112237 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNC protein_coding protein_coding 42.3063 13.67541 77.01319 2.158847 3.32398 2.492654 28.350538 9.40345824 52.751833 1.56317457 2.217444 2.4866979 0.6717167 0.6864667 0.68603333 -0.0004333333 1.000000e+00 2.947669e-19 FALSE TRUE
ENST00000523985 ENSG00000112237 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNC protein_coding protein_coding 42.3063 13.67541 77.01319 2.158847 3.32398 2.492654 2.452854 0.01986001 4.537922 0.01986001 1.229098 7.2508491 0.0348750 0.0011000 0.05813333 0.0570333333 2.269301e-05 2.947669e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112237 E001 116.8887480 0.0273530131 6.864510e-04 2.849763e-03 6 99542387 99542501 115 - 1.870 2.234 1.221
ENSG00000112237 E002 749.1297671 0.0043960161 2.511380e-08 2.871467e-07 6 99542502 99543288 787 - 2.717 2.930 0.711
ENSG00000112237 E003 198.3470894 0.0002193570 1.499683e-02 4.048024e-02 6 99543289 99543447 159 - 2.166 2.281 0.382
ENSG00000112237 E004 113.2255507 0.0016771122 1.182462e-01 2.174132e-01 6 99543448 99543463 16 - 1.955 1.918 -0.124
ENSG00000112237 E005 104.4542932 0.0007404949 1.870563e-01 3.100345e-01 6 99543464 99543474 11 - 1.918 1.894 -0.080
ENSG00000112237 E006 295.6973695 0.0001979957 1.206852e-05 7.868480e-05 6 99543475 99543609 135 - 2.376 2.293 -0.280
ENSG00000112237 E007 54.0105261 0.0004570119 1.192428e-44 5.456567e-42 6 99543780 99544178 399 - 1.380 2.112 2.480
ENSG00000112237 E008 40.5973644 0.0005435729 1.473728e-07 1.448913e-06 6 99544179 99544205 27 - 1.426 1.785 1.225
ENSG00000112237 E009 57.8685259 0.0059532253 1.508272e-10 2.581889e-09 6 99544206 99544273 68 - 1.546 1.984 1.482
ENSG00000112237 E010 265.6475992 0.0001499295 2.624071e-01 4.001926e-01 6 99545112 99545167 56 - 2.314 2.322 0.025
ENSG00000112237 E011 239.7314263 0.0002261706 9.598766e-02 1.843529e-01 6 99545168 99545204 37 - 2.272 2.261 -0.037
ENSG00000112237 E012 225.1588377 0.0001872508 1.232281e-02 3.430897e-02 6 99545205 99545230 26 - 2.251 2.212 -0.132
ENSG00000112237 E013 293.3214715 0.0001752012 8.269354e-03 2.446519e-02 6 99546395 99546474 80 - 2.364 2.331 -0.111
ENSG00000112237 E014 4.4070003 0.0047316404 8.711387e-01 9.211577e-01 6 99549312 99549388 77 - 0.624 0.681 0.245
ENSG00000112237 E015 2.5830668 0.1490453276 8.353372e-01 8.969937e-01 6 99549389 99549399 11 - 0.449 0.524 0.373
ENSG00000112237 E016 248.6843820 0.0004969959 5.335050e-05 2.985053e-04 6 99549508 99549572 65 - 2.302 2.211 -0.303
ENSG00000112237 E017 131.4022488 0.0006683369 1.379148e-02 3.775237e-02 6 99549573 99549575 3 - 2.022 1.954 -0.230
ENSG00000112237 E018 4.8143066 0.0034160056 2.341298e-01 3.672990e-01 6 99549576 99549647 72 - 0.703 0.516 -0.827
ENSG00000112237 E019 235.7080955 0.0004421896 3.482003e-03 1.167242e-02 6 99550218 99550309 92 - 2.272 2.216 -0.187
ENSG00000112237 E020 5.3052227 0.0451781668 1.606893e-02 4.288888e-02 6 99550571 99550610 40 - 0.769 0.245 -2.685
ENSG00000112237 E021 2.8704200 0.0983958825 2.121693e-01 3.410905e-01 6 99550856 99550992 137 - 0.545 0.247 -1.711
ENSG00000112237 E022 118.8135367 0.0003276557 1.304568e-02 3.601827e-02 6 99550993 99550993 1 - 1.979 1.907 -0.241
ENSG00000112237 E023 139.4055226 0.0002629221 2.338358e-02 5.854688e-02 6 99550994 99551028 35 - 2.045 1.992 -0.178
ENSG00000112237 E024 131.2894028 0.0004990637 1.136381e-01 2.108332e-01 6 99551840 99551895 56 - 2.016 1.989 -0.093
ENSG00000112237 E025 3.5064432 0.0042810259 2.685108e-01 4.069810e-01 6 99557240 99558413 1174 - 0.594 0.401 -0.946
ENSG00000112237 E026 1.1437748 0.0117642862 4.356136e-01 5.778301e-01 6 99558414 99558496 83 - 0.230 0.402 1.125
ENSG00000112237 E027 77.8425649 0.0003267185 1.892916e-01 3.128389e-01 6 99558497 99558500 4 - 1.794 1.763 -0.104
ENSG00000112237 E028 123.7999438 0.0002466948 6.568376e-01 7.662970e-01 6 99558501 99558548 48 - 1.982 2.002 0.068
ENSG00000112237 E029 202.1128364 0.0011494422 1.492366e-03 5.611575e-03 6 99561367 99561436 70 - 2.210 2.127 -0.278
ENSG00000112237 E030 261.9814792 0.0001991213 5.286871e-07 4.653975e-06 6 99561597 99561681 85 - 2.327 2.214 -0.379
ENSG00000112237 E031 0.2214452 0.0432194819 7.703950e-02   6 99561682 99561872 191 - 0.000 0.246 10.835
ENSG00000112237 E032 0.8855825 0.7052749240 4.614488e-01 6.013999e-01 6 99562020 99562841 822 - 0.192 0.387 1.368
ENSG00000112237 E033 234.8738217 0.0002156536 1.034260e-04 5.378907e-04 6 99562842 99562948 107 - 2.275 2.191 -0.281
ENSG00000112237 E034 1.7788691 0.0079200181 4.040553e-01 5.477703e-01 6 99566898 99567038 141 - 0.404 0.245 -1.014
ENSG00000112237 E035 0.9933036 0.0133321606 6.290055e-02 1.315456e-01 6 99568178 99568495 318 - 0.152 0.516 2.447
ENSG00000112237 E036 206.8378004 0.0051862933 4.759254e-03 1.525879e-02 6 99568496 99568717 222 - 2.223 2.116 -0.358
ENSG00000112237 E037 11.3275942 0.0026846412 1.430020e-01 2.521243e-01 6 99568718 99568825 108 - 1.014 0.850 -0.620