ENSG00000112234

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229971 ENSG00000112234 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL4 protein_coding protein_coding 5.580986 2.261738 9.053211 0.1455445 0.3601394 1.996226 2.0563920 0.7769657 3.9586864 0.11048437 0.2448876 2.3342889 0.34079583 0.3403000 0.43970000 0.0994000 0.40556681 0.01734881 FALSE TRUE
ENST00000369244 ENSG00000112234 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL4 protein_coding protein_coding 5.580986 2.261738 9.053211 0.1455445 0.3601394 1.996226 1.3785091 0.3366873 2.5423271 0.04007267 0.0933096 2.8801064 0.23711667 0.1513667 0.28116667 0.1298000 0.01734881 0.01734881 FALSE TRUE
MSTRG.28673.10 ENSG00000112234 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL4 protein_coding   5.580986 2.261738 9.053211 0.1455445 0.3601394 1.996226 1.2058591 0.4056651 1.6252175 0.06966442 0.2680421 1.9759889 0.21064167 0.1783333 0.17813333 -0.0002000 0.98700851 0.01734881 FALSE TRUE
MSTRG.28673.7 ENSG00000112234 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL4 protein_coding   5.580986 2.261738 9.053211 0.1455445 0.3601394 1.996226 0.1482582 0.3829356 0.3291432 0.27021754 0.3291432 -0.2123980 0.05442917 0.1718667 0.03870000 -0.1331667 0.46331823 0.01734881 FALSE TRUE
MSTRG.28673.8 ENSG00000112234 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL4 protein_coding   5.580986 2.261738 9.053211 0.1455445 0.3601394 1.996226 0.5145486 0.3594844 0.5134460 0.18147200 0.5134460 0.5025272 0.09084167 0.1581667 0.05276667 -0.1054000 0.44884295 0.01734881 FALSE TRUE
MSTRG.28673.9 ENSG00000112234 HEK293_OSMI2_2hA HEK293_TMG_2hB FBXL4 protein_coding   5.580986 2.261738 9.053211 0.1455445 0.3601394 1.996226 0.2313396 0.0000000 0.0000000 0.00000000 0.0000000 0.0000000 0.06048333 0.0000000 0.00000000 0.0000000   0.01734881 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112234 E001 177.927069 0.0002903302 9.637790e-09 1.192671e-07 6 98868535 98873724 5190 - 2.200 2.024 -0.590
ENSG00000112234 E002 25.117256 0.0009035396 5.870568e-01 7.104465e-01 6 98873725 98874156 432 - 1.340 1.302 -0.133
ENSG00000112234 E003 8.026166 0.0028545736 1.420143e-03 5.373745e-03 6 98874157 98874191 35 - 0.754 1.144 1.468
ENSG00000112234 E004 5.792087 0.0867617997 7.321638e-03 2.205467e-02 6 98874192 98874210 19 - 0.599 1.078 1.884
ENSG00000112234 E005 43.969465 0.0104527627 3.146083e-04 1.439305e-03 6 98874211 98874441 231 - 1.497 1.760 0.897
ENSG00000112234 E006 63.479048 0.0051400226 1.025919e-06 8.488702e-06 6 98875415 98875727 313 - 1.651 1.930 0.943
ENSG00000112234 E007 34.629931 0.0005782254 1.098722e-01 2.053618e-01 6 98880553 98880624 72 - 1.444 1.560 0.400
ENSG00000112234 E008 67.935883 0.0003554869 1.641144e-04 8.097875e-04 6 98899268 98899481 214 - 1.710 1.895 0.623
ENSG00000112234 E009 67.429914 0.0004299884 3.380943e-02 7.937607e-02 6 98905426 98905670 245 - 1.727 1.839 0.377
ENSG00000112234 E010 45.664707 0.0005321335 7.342345e-01 8.252412e-01 6 98917374 98917570 197 - 1.584 1.614 0.101
ENSG00000112234 E011 41.700075 0.0006151039 1.362866e-01 2.428707e-01 6 98917571 98917719 149 - 1.572 1.480 -0.313
ENSG00000112234 E012 40.796989 0.0080130757 5.484312e-02 1.177274e-01 6 98926477 98926586 110 - 1.570 1.427 -0.492
ENSG00000112234 E013 82.942892 0.0003413361 6.620698e-04 2.759916e-03 6 98926587 98927060 474 - 1.873 1.716 -0.532
ENSG00000112234 E014 34.396950 0.0025587643 2.360076e-03 8.338169e-03 6 98927705 98927822 118 - 1.513 1.271 -0.840
ENSG00000112234 E015 16.890077 0.0017197528 1.314645e-01 2.361813e-01 6 98934762 98934879 118 - 1.203 1.049 -0.552
ENSG00000112234 E016 21.059163 0.0443154096 4.294368e-02 9.643965e-02 6 98947806 98948006 201 - 1.312 1.023 -1.031