ENSG00000112210

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317483 ENSG00000112210 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB23 protein_coding protein_coding 9.574565 2.680855 18.10137 0.009590526 0.4725384 2.750759 4.6577837 1.94646425 7.804275 0.04233644 0.2408410 1.997863 0.59380833 0.72610000 0.43106667 -0.29503333 4.678515e-10 4.722299e-12 FALSE TRUE
ENST00000468148 ENSG00000112210 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB23 protein_coding protein_coding 9.574565 2.680855 18.10137 0.009590526 0.4725384 2.750759 1.1746892 0.50676151 2.365394 0.06563725 0.1212831 2.200596 0.14711250 0.18920000 0.13050000 -0.05870000 2.211690e-01 4.722299e-12 FALSE TRUE
MSTRG.28439.3 ENSG00000112210 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB23 protein_coding   9.574565 2.680855 18.10137 0.009590526 0.4725384 2.750759 0.7905168 0.07973818 1.351273 0.07973818 0.3971488 3.923090 0.06423333 0.02990000 0.07583333 0.04593333 3.990081e-01 4.722299e-12   FALSE
MSTRG.28439.5 ENSG00000112210 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB23 protein_coding   9.574565 2.680855 18.10137 0.009590526 0.4725384 2.750759 1.5942970 0.00000000 3.352152 0.00000000 0.3139720 8.393241 0.10315833 0.00000000 0.18473333 0.18473333 4.722299e-12 4.722299e-12 FALSE TRUE
MSTRG.28439.6 ENSG00000112210 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB23 protein_coding   9.574565 2.680855 18.10137 0.009590526 0.4725384 2.750759 1.2244078 0.13151536 3.043147 0.13151536 0.2518126 4.431266 0.08034167 0.04873333 0.16770000 0.11896667 1.859991e-01 4.722299e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112210 E001 41.85972 0.0259072750 1.014869e-02 2.913045e-02 6 57186992 57188782 1791 - 1.423 1.768 1.176
ENSG00000112210 E002 260.50519 0.0126530943 1.930850e-07 1.855785e-06 6 57188783 57190369 1587 - 2.212 2.530 1.061
ENSG00000112210 E003 32.67833 0.0036831678 8.015427e-01 8.735424e-01 6 57190370 57190384 15 - 1.372 1.479 0.369
ENSG00000112210 E004 43.81347 0.0006315451 6.841575e-01 7.871905e-01 6 57190385 57190450 66 - 1.496 1.612 0.396
ENSG00000112210 E005 82.93080 0.0003292606 2.852193e-01 4.255336e-01 6 57190451 57190600 150 - 1.782 1.818 0.123
ENSG00000112210 E006 69.55784 0.0009228160 1.158527e-02 3.254970e-02 6 57193842 57193934 93 - 1.720 1.662 -0.198
ENSG00000112210 E007 64.34589 0.0004852210 1.621592e-03 6.030259e-03 6 57194770 57194852 83 - 1.691 1.584 -0.361
ENSG00000112210 E008 77.13654 0.0066355709 7.550082e-02 1.523104e-01 6 57196450 57196606 157 - 1.757 1.730 -0.093
ENSG00000112210 E009 59.57730 0.0004913094 2.537985e-04 1.191047e-03 6 57207628 57207713 86 - 1.665 1.513 -0.518
ENSG00000112210 E010 82.48622 0.0003599524 2.448940e-06 1.868860e-05 6 57210226 57210445 220 - 1.806 1.629 -0.599
ENSG00000112210 E011 0.00000       6 57221319 57221407 89 -      
ENSG00000112210 E012 26.24972 0.0007783064 1.988718e-02 5.124895e-02 6 57221726 57221769 44 - 1.320 1.180 -0.492
ENSG00000112210 E013 42.33252 0.0005097003 5.274737e-04 2.262459e-03 6 57221770 57222022 253 - 1.525 1.338 -0.645
ENSG00000112210 E014 37.14990 0.0005944069 2.457505e-03 8.636164e-03 6 57222023 57222307 285 - 1.469 1.304 -0.572