ENSG00000112182

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257749 ENSG00000112182 HEK293_OSMI2_2hA HEK293_TMG_2hB BACH2 protein_coding protein_coding 1.080223 0.8707342 1.582132 0.02073067 0.1482975 0.8541818 0.86439677 0.794594014 1.0975180 0.035464606 0.03227092 0.4609973 0.83482917 0.9133 0.70170000 -0.21160000 0.05655623 0.04917646 FALSE  
ENST00000406998 ENSG00000112182 HEK293_OSMI2_2hA HEK293_TMG_2hB BACH2 protein_coding protein_coding 1.080223 0.8707342 1.582132 0.02073067 0.1482975 0.8541818 0.05362088 0.004664924 0.1217018 0.004664924 0.03486141 3.1668335 0.04532083 0.0051 0.07676667 0.07166667 0.04917646 0.04917646 FALSE  
ENST00000470301 ENSG00000112182 HEK293_OSMI2_2hA HEK293_TMG_2hB BACH2 protein_coding retained_intron 1.080223 0.8707342 1.582132 0.02073067 0.1482975 0.8541818 0.02127261 0.000000000 0.1229104 0.000000000 0.06438326 3.7323825 0.01689167 0.0000 0.08580000 0.08580000 0.35320767 0.04917646    
ENST00000481150 ENSG00000112182 HEK293_OSMI2_2hA HEK293_TMG_2hB BACH2 protein_coding processed_transcript 1.080223 0.8707342 1.582132 0.02073067 0.1482975 0.8541818 0.05127003 0.000000000 0.1243746 0.000000000 0.12437463 3.7481888 0.03817083 0.0000 0.06620000 0.06620000 0.87936271 0.04917646    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112182 E001 166.1368972 0.020776637 3.988461e-09 5.291330e-08 6 89926528 89931423 4896 - 2.057 2.382 1.086
ENSG00000112182 E002 5.0394319 0.005958049 7.573660e-01 8.422177e-01 6 89931424 89931484 61 - 0.738 0.806 0.271
ENSG00000112182 E003 26.1742287 0.000765016 1.398972e-05 8.985930e-05 6 89931485 89932407 923 - 1.484 1.318 -0.574
ENSG00000112182 E004 12.8071837 0.001708494 1.283906e-01 2.319102e-01 6 89932408 89932890 483 - 1.137 1.119 -0.067
ENSG00000112182 E005 5.2007580 0.228144819 3.294263e-02 7.769056e-02 6 89938144 89938350 207 - 0.894 0.514 -1.591
ENSG00000112182 E006 0.4375944 0.024288894 1.524638e-01 2.650294e-01 6 89950156 89950269 114 - 0.232 0.000 -12.386
ENSG00000112182 E007 29.2744287 0.048583746 4.645273e-04 2.024181e-03 6 89950270 89951862 1593 - 1.558 1.281 -0.958
ENSG00000112182 E008 0.1451727 0.042707836 6.696445e-01   6 89975550 89975903 354 - 0.092 0.000 -10.777
ENSG00000112182 E009 0.2903454 0.252105143 3.823535e-01   6 90008090 90008258 169 - 0.167 0.000 -11.081
ENSG00000112182 E010 8.7786651 0.031493764 9.989322e-03 2.873745e-02 6 90008602 90008856 255 - 1.056 0.808 -0.937
ENSG00000112182 E011 1.1135859 0.011770276 1.215677e-01 2.221705e-01 6 90062884 90062963 80 - 0.383 0.161 -1.652
ENSG00000112182 E012 0.0000000       6 90088958 90088960 3 -      
ENSG00000112182 E013 5.1403499 0.070157836 7.287841e-02 1.481241e-01 6 90088961 90089053 93 - 0.838 0.624 -0.877
ENSG00000112182 E014 1.8455646 0.115488037 3.060916e-02 7.316465e-02 6 90089054 90089065 12 - 0.555 0.162 -2.515
ENSG00000112182 E015 2.3594315 0.181741371 8.466380e-02 1.668553e-01 6 90089066 90089109 44 - 0.608 0.284 -1.731
ENSG00000112182 E016 0.0000000       6 90096931 90097145 215 -      
ENSG00000112182 E017 0.1482932 0.041213853 3.530160e-01   6 90104365 90104435 71 - 0.000 0.161 12.229
ENSG00000112182 E018 0.0000000       6 90172683 90172775 93 -      
ENSG00000112182 E019 0.1451727 0.042707836 6.696445e-01   6 90173586 90173610 25 - 0.092 0.000 -10.777
ENSG00000112182 E020 0.1451727 0.042707836 6.696445e-01   6 90176766 90176820 55 - 0.092 0.000 -10.777
ENSG00000112182 E021 3.6118725 0.004463625 4.689247e-02 1.036388e-01 6 90206569 90206676 108 - 0.719 0.512 -0.915
ENSG00000112182 E022 2.5121179 0.005946182 5.404408e-02 1.163372e-01 6 90206677 90206681 5 - 0.609 0.371 -1.182
ENSG00000112182 E023 0.0000000       6 90206682 90206689 8 -      
ENSG00000112182 E024 0.0000000       6 90217979 90218245 267 -      
ENSG00000112182 E025 0.0000000       6 90219552 90219750 199 -      
ENSG00000112182 E026 1.7296730 0.012730760 2.465839e-01 3.819422e-01 6 90252513 90252590 78 - 0.288 0.568 1.519
ENSG00000112182 E027 2.8346243 0.005546672 3.490721e-01 4.933026e-01 6 90271849 90271941 93 - 0.460 0.703 1.103
ENSG00000112182 E028 4.4890318 0.035325234 9.753829e-01 9.886449e-01 6 90296480 90296843 364 - 0.678 0.778 0.406