ENSG00000112079

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229812 ENSG00000112079 HEK293_OSMI2_2hA HEK293_TMG_2hB STK38 protein_coding protein_coding 12.58855 10.48939 14.74031 0.606696 0.6831586 0.4904405 8.8964457 8.6170480 8.836498 0.51497828 0.46955259 0.03623945 0.72566250 0.82136667 0.59970000 -0.22166667 4.286925e-09 1.539446e-18 FALSE TRUE
MSTRG.28207.2 ENSG00000112079 HEK293_OSMI2_2hA HEK293_TMG_2hB STK38 protein_coding   12.58855 10.48939 14.74031 0.606696 0.6831586 0.4904405 1.2978040 1.3204840 1.145373 0.06941504 0.20223406 -0.20359222 0.09904583 0.12680000 0.07696667 -0.04983333 1.253499e-01 1.539446e-18 FALSE TRUE
MSTRG.28207.3 ENSG00000112079 HEK293_OSMI2_2hA HEK293_TMG_2hB STK38 protein_coding   12.58855 10.48939 14.74031 0.606696 0.6831586 0.4904405 0.7765758 0.5207094 1.279634 0.14164254 0.09618923 1.28096736 0.06322500 0.04896667 0.08726667 0.03830000 2.151899e-01 1.539446e-18 FALSE TRUE
MSTRG.28207.6 ENSG00000112079 HEK293_OSMI2_2hA HEK293_TMG_2hB STK38 protein_coding   12.58855 10.48939 14.74031 0.606696 0.6831586 0.4904405 1.4819390 0.0000000 3.099582 0.00000000 0.44172126 8.28057663 0.10260417 0.00000000 0.21063333 0.21063333 1.539446e-18 1.539446e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112079 E001 50.676836 0.0114603391 3.349979e-05 1.968619e-04 6 36493892 36494004 113 - 1.539 1.845 1.036
ENSG00000112079 E002 203.814365 0.0030762140 4.458893e-15 1.545981e-13 6 36494005 36494389 385 - 2.153 2.430 0.925
ENSG00000112079 E003 64.797683 0.0004325173 2.079075e-08 2.416112e-07 6 36494390 36494420 31 - 1.676 1.929 0.853
ENSG00000112079 E004 66.845698 0.0005126215 1.052115e-06 8.690651e-06 6 36494421 36494468 48 - 1.715 1.932 0.732
ENSG00000112079 E005 129.369010 0.0003380262 3.224693e-10 5.222333e-09 6 36494469 36494637 169 - 2.008 2.209 0.673
ENSG00000112079 E006 424.684851 0.0001770257 2.017287e-03 7.280113e-03 6 36494638 36495914 1277 - 2.604 2.659 0.183
ENSG00000112079 E007 86.553576 0.0003304708 5.479523e-03 1.723406e-02 6 36496711 36496805 95 - 1.990 1.891 -0.333
ENSG00000112079 E008 84.126664 0.0004095876 5.766963e-02 1.226287e-01 6 36497780 36497875 96 - 1.964 1.897 -0.227
ENSG00000112079 E009 96.086825 0.0082054461 3.066484e-01 4.488350e-01 6 36498363 36498486 124 - 2.015 1.959 -0.186
ENSG00000112079 E010 83.818656 0.0008907160 4.932944e-02 1.079714e-01 6 36499873 36499990 118 - 1.964 1.891 -0.246
ENSG00000112079 E011 61.975359 0.0013847816 1.477636e-01 2.586422e-01 6 36506583 36506644 62 - 1.831 1.768 -0.212
ENSG00000112079 E012 77.085475 0.0003503487 1.701693e-02 4.497185e-02 6 36507500 36507602 103 - 1.938 1.849 -0.300
ENSG00000112079 E013 97.078075 0.0003455084 3.673621e-04 1.647936e-03 6 36515338 36515492 155 - 2.052 1.931 -0.407
ENSG00000112079 E014 93.256465 0.0003139919 2.111597e-03 7.570411e-03 6 36517717 36517840 124 - 2.026 1.920 -0.356
ENSG00000112079 E015 78.333516 0.0026779947 2.269811e-04 1.078987e-03 6 36521734 36521817 84 - 1.973 1.804 -0.566
ENSG00000112079 E016 86.722902 0.0009035733 2.560059e-05 1.548319e-04 6 36524341 36524463 123 - 2.016 1.854 -0.544
ENSG00000112079 E017 60.855475 0.0030858732 3.986620e-05 2.298635e-04 6 36525591 36525642 52 - 1.883 1.672 -0.714
ENSG00000112079 E018 83.495558 0.0075910144 2.567282e-04 1.203305e-03 6 36540072 36540204 133 - 2.018 1.810 -0.699
ENSG00000112079 E019 14.569027 0.0012710406 2.900968e-03 9.971870e-03 6 36540205 36540207 3 - 1.302 1.040 -0.936
ENSG00000112079 E020 6.578434 0.0025443505 2.343465e-02 5.865302e-02 6 36541769 36541874 106 - 0.997 0.722 -1.066
ENSG00000112079 E021 2.879577 0.0053109060 7.344977e-01 8.254292e-01 6 36541875 36541935 61 - 0.566 0.623 0.255
ENSG00000112079 E022 72.710342 0.0036975322 1.066490e-07 1.077852e-06 6 36547190 36547540 351 - 1.981 1.715 -0.898