ENSG00000112039

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229769 ENSG00000112039 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCE protein_coding protein_coding 19.83037 29.05833 11.5827 1.426162 0.6605366 -1.326231 8.745352 13.014563 4.9599038 1.96787219 0.2849772 -1.389945088 0.42818333 0.44416667 0.43076667 -0.01340000 0.967852129 0.001496005 FALSE  
ENST00000696264 ENSG00000112039 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCE protein_coding nonsense_mediated_decay 19.83037 29.05833 11.5827 1.426162 0.6605366 -1.326231 1.636696 2.924507 1.0429811 0.57899066 0.1360862 -1.478638653 0.08425000 0.10073333 0.08926667 -0.01146667 0.912572365 0.001496005 FALSE  
ENST00000696266 ENSG00000112039 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCE protein_coding nonsense_mediated_decay 19.83037 29.05833 11.5827 1.426162 0.6605366 -1.326231 1.332960 2.769078 0.4893053 0.23832726 0.2713223 -2.476612348 0.05677917 0.09656667 0.04233333 -0.05423333 0.522159963 0.001496005 TRUE  
ENST00000696268 ENSG00000112039 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCE protein_coding retained_intron 19.83037 29.05833 11.5827 1.426162 0.6605366 -1.326231 1.253351 1.041102 1.0440894 0.03748704 0.1972111 0.004094785 0.06905833 0.03603333 0.08873333 0.05270000 0.001496005 0.001496005 FALSE  
ENST00000696269 ENSG00000112039 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCE protein_coding retained_intron 19.83037 29.05833 11.5827 1.426162 0.6605366 -1.326231 1.595717 1.531326 1.1915929 0.19470900 0.1620363 -0.359223626 0.08587083 0.05230000 0.10220000 0.04990000 0.008828035 0.001496005    
MSTRG.28184.8 ENSG00000112039 HEK293_OSMI2_2hA HEK293_TMG_2hB FANCE protein_coding   19.83037 29.05833 11.5827 1.426162 0.6605366 -1.326231 2.661695 5.434205 0.9277027 0.47471704 0.3321523 -2.537518867 0.12643750 0.18866667 0.07900000 -0.10966667 0.060698236 0.001496005 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000112039 E001 9.229571 0.0292147835 2.840029e-02 6.881779e-02 6 35452338 35452355 18 + 1.140 0.853 -1.061
ENSG00000112039 E002 32.048714 0.0135291492 4.273618e-02 9.606019e-02 6 35452356 35452382 27 + 1.557 1.389 -0.578
ENSG00000112039 E003 45.475869 0.0095588765 5.152951e-02 1.118700e-01 6 35452383 35452418 36 + 1.684 1.547 -0.466
ENSG00000112039 E004 57.495640 0.0151702217 1.043654e-02 2.983239e-02 6 35452419 35452545 127 + 1.820 1.633 -0.634
ENSG00000112039 E005 101.104771 0.0113407850 1.338823e-01 2.395482e-01 6 35452546 35452793 248 + 1.993 1.903 -0.301
ENSG00000112039 E006 3.573058 0.0251904962 2.257214e-02 5.686544e-02 6 35452933 35452949 17 + 0.852 0.490 -1.546
ENSG00000112039 E007 4.057692 0.0080505726 5.097781e-02 1.109061e-01 6 35452950 35452996 47 + 0.852 0.564 -1.199
ENSG00000112039 E008 73.158717 0.0005680883 3.517046e-01 4.959388e-01 6 35455747 35455780 34 + 1.816 1.772 -0.149
ENSG00000112039 E009 112.684902 0.0049288347 3.660727e-01 5.104169e-01 6 35455781 35455858 78 + 2.000 1.960 -0.134
ENSG00000112039 E010 346.645271 0.0006408298 1.778781e-01 2.984755e-01 6 35455859 35456353 495 + 2.429 2.462 0.111
ENSG00000112039 E011 73.405064 0.0003884470 8.918072e-01 9.349171e-01 6 35457556 35457600 45 + 1.782 1.788 0.022
ENSG00000112039 E012 14.257365 0.0014252874 5.606348e-07 4.913744e-06 6 35457601 35457788 188 + 1.406 0.954 -1.612
ENSG00000112039 E013 7.709427 0.0080555981 3.672579e-03 1.221852e-02 6 35457789 35457915 127 + 1.103 0.747 -1.347
ENSG00000112039 E014 83.398975 0.0009536624 1.552024e-01 2.686570e-01 6 35457916 35457984 69 + 1.786 1.854 0.230
ENSG00000112039 E015 9.071283 0.0426187028 2.645277e-02 6.485484e-02 6 35457985 35458296 312 + 1.139 0.833 -1.139
ENSG00000112039 E016 56.413043 0.0007353766 5.281722e-02 1.141632e-01 6 35458297 35458317 21 + 1.589 1.700 0.379
ENSG00000112039 E017 136.503664 0.0008989919 3.351728e-01 4.789443e-01 6 35458318 35458440 123 + 2.028 2.065 0.124
ENSG00000112039 E018 93.977750 0.0079011008 8.387834e-01 8.992425e-01 6 35459331 35459357 27 + 1.906 1.898 -0.028
ENSG00000112039 E019 146.449404 0.0003183783 6.164450e-01 7.345028e-01 6 35459358 35459454 97 + 2.073 2.090 0.058
ENSG00000112039 E020 131.797460 0.0002882228 2.568861e-01 3.939029e-01 6 35459682 35459760 79 + 2.005 2.046 0.139
ENSG00000112039 E021 73.211851 0.0005985697 8.860621e-02 1.729963e-01 6 35460552 35460555 4 + 1.717 1.803 0.290
ENSG00000112039 E022 120.277211 0.0002785086 5.177750e-01 6.521092e-01 6 35460556 35460618 63 + 1.980 2.005 0.082
ENSG00000112039 E023 12.664715 0.0014127700 8.537572e-03 2.513274e-02 6 35460619 35460946 328 + 1.247 0.990 -0.929
ENSG00000112039 E024 38.995251 0.0054502500 4.240194e-06 3.065532e-05 6 35461790 35462788 999 + 1.735 1.427 -1.053
ENSG00000112039 E025 184.258957 0.0011864608 4.180556e-01 5.613673e-01 6 35462789 35462914 126 + 2.165 2.193 0.095
ENSG00000112039 E026 2.716519 0.2700208041 9.528114e-01 9.744508e-01 6 35463848 35463980 133 + 0.576 0.492 -0.394
ENSG00000112039 E027 566.505344 0.0027713399 7.302936e-03 2.200743e-02 6 35466244 35467104 861 + 2.613 2.688 0.247