ENSG00000111962

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367463 ENSG00000111962 HEK293_OSMI2_2hA HEK293_TMG_2hB UST protein_coding protein_coding 9.266908 7.646729 13.05188 1.2901 0.4889261 0.7705623 4.1216590 2.4305649 7.2284709 0.1169575 0.665280370 1.5684698 0.43895833 0.34186667 0.55853333 0.21666667 0.19573574 0.02254219 FALSE  
ENST00000466695 ENSG00000111962 HEK293_OSMI2_2hA HEK293_TMG_2hB UST protein_coding processed_transcript 9.266908 7.646729 13.05188 1.2901 0.4889261 0.7705623 0.9412684 0.6344750 1.0396526 0.6344750 0.546908802 0.7037156 0.09044167 0.06373333 0.07716667 0.01343333 0.69091102 0.02254219    
ENST00000473631 ENSG00000111962 HEK293_OSMI2_2hA HEK293_TMG_2hB UST protein_coding processed_transcript 9.266908 7.646729 13.05188 1.2901 0.4889261 0.7705623 0.2950405 0.8740365 0.1487551 0.4120325 0.004400151 -2.4773027 0.03886250 0.10170000 0.01140000 -0.09030000 0.02254219 0.02254219    
MSTRG.29118.3 ENSG00000111962 HEK293_OSMI2_2hA HEK293_TMG_2hB UST protein_coding   9.266908 7.646729 13.05188 1.2901 0.4889261 0.7705623 0.9431094 1.0042219 0.5779612 0.2160767 0.321898567 -0.7865804 0.10442083 0.12920000 0.04320000 -0.08600000 0.38203568 0.02254219 FALSE  
MSTRG.29118.4 ENSG00000111962 HEK293_OSMI2_2hA HEK293_TMG_2hB UST protein_coding   9.266908 7.646729 13.05188 1.2901 0.4889261 0.7705623 2.8290533 2.5838525 3.8459267 0.3004752 0.641668189 0.5719812 0.31314167 0.34566667 0.29296667 -0.05270000 0.73084588 0.02254219 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111962 E001 30.3596926 0.0430897571 0.647617275 0.75926672 6 148747030 148747448 419 + 1.518 1.439 -0.272
ENSG00000111962 E002 37.5945519 0.0212398884 0.768439905 0.85036875 6 148747449 148747605 157 + 1.577 1.580 0.010
ENSG00000111962 E003 46.6372008 0.0040165521 0.229609011 0.36197066 6 148747606 148747677 72 + 1.703 1.618 -0.286
ENSG00000111962 E004 48.1919526 0.0108783005 0.348373577 0.49259837 6 148886986 148887029 44 + 1.717 1.633 -0.287
ENSG00000111962 E005 81.3661100 0.0059423697 0.711738325 0.80864493 6 148941279 148941434 156 + 1.924 1.890 -0.115
ENSG00000111962 E006 40.9482707 0.0012113941 0.571003729 0.69739444 6 148953872 148953906 35 + 1.608 1.631 0.080
ENSG00000111962 E007 45.5130790 0.0005303444 0.673810003 0.77939379 6 148953907 148953951 45 + 1.658 1.672 0.049
ENSG00000111962 E008 76.2550442 0.0004033301 0.008163678 0.02419770 6 148964410 148964563 154 + 1.844 1.942 0.328
ENSG00000111962 E009 4.0541033 0.1893250500 0.006491261 0.01990048 6 149005303 149005588 286 + 0.300 0.989 3.137
ENSG00000111962 E010 58.8955944 0.0004214692 0.998047400 1.00000000 6 149019139 149019236 98 + 1.777 1.770 -0.024
ENSG00000111962 E011 87.8738041 0.0004458373 0.323472301 0.46680929 6 149021324 149021481 158 + 1.933 1.962 0.098
ENSG00000111962 E012 0.0000000       6 149066176 149066254 79 +      
ENSG00000111962 E013 112.9172162 0.0002569415 0.581149152 0.70574072 6 149073833 149074112 280 + 2.064 2.038 -0.086
ENSG00000111962 E014 484.9849672 0.0161463103 0.515514973 0.65017918 6 149074113 149076990 2878 + 2.694 2.662 -0.108
ENSG00000111962 E015 2.6821930 0.1148368872 0.663816149 0.77179942 6 149077354 149077476 123 + 0.542 0.598 0.257
ENSG00000111962 E016 0.1451727 0.0430111028 0.856399486   6 149077943 149077988 46 + 0.096 0.001 -7.354
ENSG00000111962 E017 1.7640029 0.1703330946 0.336857343 0.48071692 6 149093801 149093940 140 + 0.350 0.548 1.030