ENSG00000111912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368357 ENSG00000111912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA7 protein_coding protein_coding 5.496872 4.304578 6.804962 0.3135491 0.5060474 0.6594863 0.5338908 0.33829443 0.8077714 0.04587963 0.4058784 1.2313902 0.08535833 0.078833333 0.1291667 0.05033333 9.149550e-01 1.872926e-28 FALSE TRUE
ENST00000392477 ENSG00000111912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA7 protein_coding protein_coding 5.496872 4.304578 6.804962 0.3135491 0.5060474 0.6594863 1.1380247 0.00000000 1.6944963 0.00000000 0.3973951 7.4132016 0.18298750 0.000000000 0.2441000 0.24410000 1.873296e-10 1.872926e-28 FALSE TRUE
ENST00000417494 ENSG00000111912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA7 protein_coding protein_coding 5.496872 4.304578 6.804962 0.3135491 0.5060474 0.6594863 0.4682390 0.00000000 1.1465617 0.00000000 0.1331331 6.8536984 0.06175417 0.000000000 0.1718000 0.17180000 2.387097e-10 1.872926e-28 FALSE FALSE
ENST00000433571 ENSG00000111912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA7 protein_coding processed_transcript 5.496872 4.304578 6.804962 0.3135491 0.5060474 0.6594863 0.5877963 0.03552845 0.5313195 0.03552845 0.5313195 3.5716401 0.08467917 0.007666667 0.0697000 0.06203333 1.000000e+00 1.872926e-28 FALSE FALSE
MSTRG.28918.1 ENSG00000111912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA7 protein_coding   5.496872 4.304578 6.804962 0.3135491 0.5060474 0.6594863 1.9812205 3.60490365 1.8676905 0.27452638 0.2372015 -0.9449979 0.44087917 0.837166667 0.2724000 -0.56476667 1.872926e-28 1.872926e-28   FALSE
MSTRG.28918.3 ENSG00000111912 HEK293_OSMI2_2hA HEK293_TMG_2hB NCOA7 protein_coding   5.496872 4.304578 6.804962 0.3135491 0.5060474 0.6594863 0.4095487 0.14600936 0.1999579 0.07301222 0.1025560 0.4284673 0.07333333 0.035700000 0.0318000 -0.00390000 9.683389e-01 1.872926e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111912 E001 6.1977004 0.0034332903 1.939492e-08 2.268092e-07 6 125781130 125781160 31 + 0.515 1.221 2.784
ENSG00000111912 E002 24.5110628 0.0008558464 3.015027e-28 4.353565e-26 6 125781161 125781371 211 + 1.004 1.781 2.708
ENSG00000111912 E003 20.3476475 0.0009723477 1.345801e-24 1.414076e-22 6 125786137 125786213 77 + 0.911 1.704 2.797
ENSG00000111912 E004 11.9738799 0.0036074411 8.136556e-24 7.917032e-22 6 125788726 125788924 199 + 0.536 1.560 3.857
ENSG00000111912 E005 0.8116123 0.1397019359 3.669913e-01 5.113553e-01 6 125790925 125790939 15 + 0.172 0.364 1.426
ENSG00000111912 E006 1.3943794 0.0348762601 9.039360e-01 9.428759e-01 6 125790940 125790959 20 + 0.329 0.363 0.203
ENSG00000111912 E007 1.5395521 0.1029279815 9.838004e-01 9.939420e-01 6 125790960 125790964 5 + 0.361 0.363 0.014
ENSG00000111912 E008 5.3749381 0.0039010385 1.103726e-02 3.125027e-02 6 125790965 125791067 103 + 0.814 0.363 -2.079
ENSG00000111912 E009 0.7374030 0.0157250507 1.000000e+00 1.000000e+00 6 125796680 125796797 118 + 0.217 0.218 0.007
ENSG00000111912 E010 0.0000000       6 125810135 125810347 213 +      
ENSG00000111912 E011 0.1817044 0.0398673810 1.121863e-01   6 125815218 125815290 73 + 0.000 0.218 12.403
ENSG00000111912 E012 13.8463881 0.0015042828 2.969133e-05 1.769014e-04 6 125815291 125815404 114 + 1.184 0.630 -2.129
ENSG00000111912 E013 20.0397701 0.0049283821 2.802133e-03 9.681317e-03 6 125855020 125855240 221 + 1.308 1.006 -1.080
ENSG00000111912 E014 0.0000000       6 125855241 125855590 350 +      
ENSG00000111912 E015 11.3152025 0.0236584179 5.290344e-02 1.143118e-01 6 125874889 125874968 80 + 1.069 0.795 -1.034
ENSG00000111912 E016 13.3901403 0.0013073953 9.049194e-03 2.640090e-02 6 125878263 125878370 108 + 1.140 0.837 -1.125
ENSG00000111912 E017 14.4513024 0.0011978824 2.945828e-04 1.357855e-03 6 125881090 125881203 114 + 1.189 0.746 -1.660
ENSG00000111912 E018 15.4017447 0.0012301900 1.189108e-03 4.604550e-03 6 125882426 125882551 126 + 1.207 0.837 -1.361
ENSG00000111912 E019 22.4466703 0.0009086656 6.926416e-05 3.764815e-04 6 125885159 125885343 185 + 1.363 0.977 -1.379
ENSG00000111912 E020 9.5404184 0.0042358543 1.204429e-01 2.205979e-01 6 125888939 125888971 33 + 0.989 0.794 -0.745
ENSG00000111912 E021 70.3580023 0.0005063064 3.698884e-07 3.358781e-06 6 125888972 125889981 1010 + 1.827 1.575 -0.857
ENSG00000111912 E022 19.9364795 0.0176955303 2.049078e-03 7.377967e-03 6 125890642 125890810 169 + 1.312 0.946 -1.316
ENSG00000111912 E023 0.2214452 0.0386798305 1.118532e-01   6 125899909 125900021 113 + 0.000 0.219 12.413
ENSG00000111912 E024 23.0747680 0.0199608376 2.823764e-04 1.308051e-03 6 125915333 125915480 148 + 1.378 0.947 -1.544
ENSG00000111912 E025 0.1472490 0.0433138566 1.000000e+00   6 125919224 125919304 81 + 0.065 0.000 -10.295
ENSG00000111912 E026 0.2987644 0.0273090993 1.000000e+00   6 125919305 125919431 127 + 0.122 0.000 -11.317
ENSG00000111912 E027 19.5172538 0.0382151825 8.354861e-03 2.467809e-02 6 125920943 125921068 126 + 1.304 0.945 -1.292
ENSG00000111912 E028 16.0334103 0.0011703056 9.352478e-02 1.806318e-01 6 125922682 125922834 153 + 1.193 1.033 -0.577
ENSG00000111912 E029 16.4372442 0.0011578331 8.592578e-03 2.526993e-02 6 125927663 125927758 96 + 1.220 0.946 -0.992
ENSG00000111912 E030 13.4525945 0.0012712068 4.600369e-02 1.020416e-01 6 125928174 125928247 74 + 1.130 0.913 -0.799
ENSG00000111912 E031 117.2582719 0.0029194143 6.476035e-04 2.707535e-03 6 125928636 125932034 3399 + 1.959 2.107 0.494