ENSG00000111907

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368388 ENSG00000111907 HEK293_OSMI2_2hA HEK293_TMG_2hB TPD52L1 protein_coding protein_coding 7.035344 9.980292 8.227198 0.2673086 0.3915666 -0.2783732 1.539647 2.443019 1.4837345 0.3340967 0.05764271 -0.7156346 0.2277083 0.2440000 0.1817000 -0.0623000 0.3998560092 0.0002181709 FALSE TRUE
ENST00000368402 ENSG00000111907 HEK293_OSMI2_2hA HEK293_TMG_2hB TPD52L1 protein_coding protein_coding 7.035344 9.980292 8.227198 0.2673086 0.3915666 -0.2783732 1.090093 1.751409 0.9679363 0.2509153 0.33836943 -0.8489173 0.1538500 0.1750667 0.1145667 -0.0605000 0.4867879665 0.0002181709 FALSE TRUE
ENST00000392483 ENSG00000111907 HEK293_OSMI2_2hA HEK293_TMG_2hB TPD52L1 protein_coding retained_intron 7.035344 9.980292 8.227198 0.2673086 0.3915666 -0.2783732 2.764286 3.130080 4.4038814 0.2276777 0.28071691 0.4912468 0.3844042 0.3152333 0.5346333 0.2194000 0.0002181709 0.0002181709 FALSE TRUE
ENST00000534000 ENSG00000111907 HEK293_OSMI2_2hA HEK293_TMG_2hB TPD52L1 protein_coding protein_coding 7.035344 9.980292 8.227198 0.2673086 0.3915666 -0.2783732 1.307787 2.356853 1.0992629 0.0808650 0.13270929 -1.0933688 0.1829000 0.2362667 0.1355000 -0.1007667 0.0308533971 0.0002181709 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111907 E001 0.0000000       6 125119049 125119388 340 +      
ENSG00000111907 E002 0.6966155 0.0169684997 6.522155e-01 7.629344e-01 6 125153649 125153732 84 + 0.158 0.237 0.732
ENSG00000111907 E003 5.0425618 0.0079119382 6.435056e-01 7.560370e-01 6 125153733 125153764 32 + 0.796 0.729 -0.267
ENSG00000111907 E004 10.3462527 0.0162338227 1.130678e-01 2.100097e-01 6 125153765 125153772 8 + 1.150 0.964 -0.678
ENSG00000111907 E005 15.2518970 0.0328086213 5.891627e-01 7.122489e-01 6 125153773 125153792 20 + 1.235 1.164 -0.251
ENSG00000111907 E006 33.1061980 0.0007209032 5.615220e-01 6.893113e-01 6 125153793 125153848 56 + 1.535 1.498 -0.125
ENSG00000111907 E007 36.4606793 0.0056790595 4.265296e-01 5.693523e-01 6 125153849 125153899 51 + 1.587 1.529 -0.198
ENSG00000111907 E008 54.2189854 0.0012508536 5.318397e-01 6.642369e-01 6 125153900 125153970 71 + 1.739 1.706 -0.112
ENSG00000111907 E009 0.2214452 0.0404579491 8.194922e-01   6 125154189 125154380 192 + 0.000 0.094 10.543
ENSG00000111907 E010 0.3697384 0.0274424043 4.113587e-01 5.549235e-01 6 125154381 125154532 152 + 0.000 0.172 11.613
ENSG00000111907 E011 0.0000000       6 125203639 125203777 139 +      
ENSG00000111907 E012 0.0000000       6 125219845 125220077 233 +      
ENSG00000111907 E013 91.5839575 0.0004285007 4.615769e-01 6.015090e-01 6 125220078 125220193 116 + 1.960 1.931 -0.094
ENSG00000111907 E014 0.0000000       6 125229067 125229117 51 +      
ENSG00000111907 E015 118.0253389 0.0003312711 5.488229e-02 1.177936e-01 6 125229118 125229266 149 + 2.087 2.025 -0.206
ENSG00000111907 E016 0.0000000       6 125231207 125231237 31 +      
ENSG00000111907 E017 97.8828156 0.0006477249 2.955838e-01 4.367091e-01 6 125248282 125248383 102 + 1.992 1.953 -0.129
ENSG00000111907 E018 0.0000000       6 125248384 125248475 92 +      
ENSG00000111907 E019 0.0000000       6 125252022 125252036 15 +      
ENSG00000111907 E020 0.4741261 0.0221192752 2.850083e-01 4.253101e-01 6 125252037 125253716 1680 + 0.273 0.094 -1.853
ENSG00000111907 E021 34.8235372 0.0033303170 2.970785e-01 4.383909e-01 6 125253717 125253755 39 + 1.475 1.543 0.231
ENSG00000111907 E022 0.2944980 0.3577168961 1.460659e-01   6 125253756 125253799 44 + 0.273 0.000 -12.583
ENSG00000111907 E023 24.6964732 0.0056855059 4.819523e-01 6.201313e-01 6 125257098 125257158 61 + 1.342 1.397 0.189
ENSG00000111907 E024 0.6244956 0.0470091452 5.691786e-01 6.957799e-01 6 125257159 125257180 22 + 0.273 0.171 -0.856
ENSG00000111907 E025 0.2924217 0.0290785164 8.621631e-02   6 125259963 125260380 418 + 0.273 0.000 -13.641
ENSG00000111907 E026 3.8415438 0.0066252946 4.515203e-01 5.924709e-01 6 125261011 125262833 1823 + 0.730 0.618 -0.475
ENSG00000111907 E027 195.3536544 0.0002584651 8.782014e-06 5.912673e-05 6 125262834 125264407 1574 + 2.190 2.296 0.354