ENSG00000111906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398153 ENSG00000111906 HEK293_OSMI2_2hA HEK293_TMG_2hB HDDC2 protein_coding protein_coding 116.1597 102.1104 153.2176 13.02088 3.2868 0.585405 12.174522 8.369050 20.726887 0.2264917 1.554345 1.3073408 0.09950833 0.08403333 0.13576667 0.05173333 0.04475153 0.04475153 FALSE  
ENST00000608295 ENSG00000111906 HEK293_OSMI2_2hA HEK293_TMG_2hB HDDC2 protein_coding protein_coding 116.1597 102.1104 153.2176 13.02088 3.2868 0.585405 20.206176 20.425510 24.915785 2.4903382 1.838273 0.2865607 0.17826250 0.20093333 0.16233333 -0.03860000 0.26359581 0.04475153 TRUE  
ENST00000608461 ENSG00000111906 HEK293_OSMI2_2hA HEK293_TMG_2hB HDDC2 protein_coding retained_intron 116.1597 102.1104 153.2176 13.02088 3.2868 0.585405 8.077522 2.704925 4.516496 1.8008993 2.678081 0.7374825 0.06485000 0.02343333 0.02873333 0.00530000 1.00000000 0.04475153    
ENST00000609477 ENSG00000111906 HEK293_OSMI2_2hA HEK293_TMG_2hB HDDC2 protein_coding nonsense_mediated_decay 116.1597 102.1104 153.2176 13.02088 3.2868 0.585405 22.738550 20.096832 38.993824 0.9168209 2.478933 0.9559298 0.19829583 0.20310000 0.25540000 0.05230000 0.50901942 0.04475153    
MSTRG.28916.10 ENSG00000111906 HEK293_OSMI2_2hA HEK293_TMG_2hB HDDC2 protein_coding   116.1597 102.1104 153.2176 13.02088 3.2868 0.585405 42.878832 39.354133 54.146061 6.2520761 2.825023 0.4602411 0.36964167 0.38280000 0.35296667 -0.02983333 0.61584704 0.04475153 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111906 E001 1.2783384 1.382747e-02 2.639193e-01 4.018447e-01 6 125219962 125220152 191 - 0.437 0.239 -1.248
ENSG00000111906 E002 0.1472490 4.342867e-02 6.171804e-01   6 125221845 125221927 83 - 0.110 0.000 -8.627
ENSG00000111906 E003 0.0000000       6 125221928 125221983 56 -      
ENSG00000111906 E004 0.8825612 2.880576e-01 9.038613e-01 9.428292e-01 6 125234346 125234413 68 - 0.271 0.245 -0.195
ENSG00000111906 E005 5.7548840 2.894296e-03 7.321351e-02 1.486627e-01 6 125265182 125265352 171 - 0.704 0.938 0.919
ENSG00000111906 E006 39.2170552 1.123028e-02 1.146777e-01 2.123606e-01 6 125275350 125275700 351 - 1.662 1.551 -0.378
ENSG00000111906 E007 27.4698316 4.991480e-03 4.496719e-01 5.908598e-01 6 125275701 125275811 111 - 1.485 1.440 -0.157
ENSG00000111906 E008 19.2549603 1.813121e-03 7.206823e-01 8.152668e-01 6 125275812 125275881 70 - 1.322 1.301 -0.075
ENSG00000111906 E009 9.8104004 1.741983e-03 8.925176e-02 1.739985e-01 6 125275882 125275884 3 - 0.946 1.128 0.666
ENSG00000111906 E010 9.6588850 1.848848e-03 6.794932e-02 1.399640e-01 6 125275885 125275885 1 - 0.931 1.128 0.721
ENSG00000111906 E011 996.0161856 7.048314e-04 4.593906e-14 1.369691e-12 6 125275886 125276162 277 - 2.941 3.061 0.399
ENSG00000111906 E012 867.8679755 3.534663e-04 2.136162e-06 1.651075e-05 6 125276163 125276243 81 - 2.909 2.979 0.236
ENSG00000111906 E013 36.5872005 6.004287e-04 5.475748e-02 1.175710e-01 6 125276244 125276954 711 - 1.517 1.634 0.399
ENSG00000111906 E014 9.0176421 2.086745e-03 7.858295e-01 8.628220e-01 6 125276955 125277078 124 - 0.986 1.021 0.128
ENSG00000111906 E015 5.7768589 4.877007e-02 7.509449e-01 8.375087e-01 6 125277079 125277101 23 - 0.813 0.856 0.170
ENSG00000111906 E016 1200.2280591 1.022031e-04 1.440577e-01 2.535283e-01 6 125277102 125277240 139 - 3.075 3.095 0.068
ENSG00000111906 E017 1.7597602 1.302640e-02 2.812773e-03 9.712234e-03 6 125277241 125279414 2174 - 0.110 0.632 3.505
ENSG00000111906 E018 18.9241461 9.501530e-04 4.549572e-01 5.955329e-01 6 125292828 125292840 13 - 1.328 1.276 -0.180
ENSG00000111906 E019 921.2162718 9.377605e-05 4.311635e-03 1.401748e-02 6 125292841 125292909 69 - 2.983 2.956 -0.088
ENSG00000111906 E020 3.4125854 4.249080e-02 7.878067e-01 8.640815e-01 6 125292910 125293231 322 - 0.622 0.667 0.193
ENSG00000111906 E021 6.2968582 4.819243e-03 1.820047e-01 3.037344e-01 6 125297487 125297569 83 - 0.946 0.786 -0.615
ENSG00000111906 E022 3.9207550 9.005882e-02 2.039441e-02 5.231483e-02 6 125298650 125298713 64 - 0.866 0.391 -2.122
ENSG00000111906 E023 729.4621015 4.565606e-04 6.003452e-09 7.729092e-08 6 125298714 125298816 103 - 2.908 2.820 -0.294
ENSG00000111906 E024 1.6638958 1.095084e-01 7.166482e-01 8.122455e-01 6 125300277 125300537 261 - 0.389 0.453 0.339
ENSG00000111906 E025 1041.3816017 8.219782e-05 6.783253e-10 1.038522e-08 6 125300538 125300659 122 - 3.051 2.991 -0.199
ENSG00000111906 E026 7.5734315 1.534723e-02 4.169744e-01 5.603643e-01 6 125301598 125301848 251 - 0.885 0.989 0.391
ENSG00000111906 E027 550.4856031 1.466721e-03 2.718353e-02 6.636561e-02 6 125301849 125302032 184 - 2.769 2.716 -0.178
ENSG00000111906 E028 20.7142701 1.269378e-03 3.493871e-01 4.935978e-01 6 125302033 125302339 307 - 1.310 1.387 0.267