ENSG00000111897

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339697 ENSG00000111897 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC1 protein_coding protein_coding 62.78647 13.62374 96.48032 1.02714 2.744993 2.823202 54.0121 13.62374 81.49192 1.02714 2.6817047 2.579652 0.92105417 1 0.8445 -0.1555 4.422092e-35 6.791288e-36 FALSE TRUE
MSTRG.28901.3 ENSG00000111897 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC1 protein_coding   62.78647 13.62374 96.48032 1.02714 2.744993 2.823202 8.7457 0.00000 14.91389 0.00000 0.6863626 10.543408 0.07835417 0 0.1547 0.1547 6.791288e-36 6.791288e-36 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111897 E001 32.682264 0.0036086264 7.655394e-15 2.564165e-13 6 122443351 122443385 35 - 1.221 1.837 2.116
ENSG00000111897 E002 933.467038 0.0070258013 9.324542e-15 3.080221e-13 6 122443386 122444283 898 - 2.744 3.096 1.171
ENSG00000111897 E003 1535.086209 0.0004736253 1.287904e-03 4.936163e-03 6 122444284 122445179 896 - 3.013 3.122 0.362
ENSG00000111897 E004 613.489247 0.0001288682 1.208454e-02 3.373731e-02 6 122446774 122447004 231 - 2.630 2.647 0.057
ENSG00000111897 E005 457.575144 0.0001509990 1.349368e-05 8.697981e-05 6 122447121 122447265 145 - 2.511 2.473 -0.125
ENSG00000111897 E006 391.345153 0.0002650857 1.179895e-06 9.652286e-06 6 122451664 122451754 91 - 2.446 2.382 -0.215
ENSG00000111897 E007 497.758908 0.0002436159 9.229897e-14 2.636972e-12 6 122451888 122452057 170 - 2.556 2.440 -0.389
ENSG00000111897 E008 408.254035 0.0009919151 6.623609e-07 5.718296e-06 6 122453770 122453907 138 - 2.466 2.383 -0.276
ENSG00000111897 E009 271.214574 0.0001764204 1.101115e-03 4.306775e-03 6 122454151 122454230 80 - 2.284 2.249 -0.118
ENSG00000111897 E010 337.565137 0.0029760853 2.174942e-02 5.515557e-02 6 122456481 122456650 170 - 2.377 2.355 -0.075
ENSG00000111897 E011 441.318434 0.0001351537 2.971880e-13 7.895299e-12 6 122458520 122458681 162 - 2.505 2.385 -0.400
ENSG00000111897 E012 1.066356 0.0117929201 3.111149e-01 4.535574e-01 6 122471694 122471698 5 - 0.204 0.441 1.554
ENSG00000111897 E013 294.121240 0.0001454344 3.339500e-14 1.016809e-12 6 122471699 122471853 155 - 2.336 2.155 -0.603