ENSG00000111877

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316068 ENSG00000111877 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM9 protein_coding protein_coding 10.23895 5.501158 14.36573 0.4380758 0.445648 1.383208 1.0311346 0.42711298 0.8864501 0.03668998 0.09553918 1.0362170 0.10901667 0.077766667 0.06143333 -0.01633333 6.605332e-01 6.369714e-08 FALSE TRUE
ENST00000316316 ENSG00000111877 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM9 protein_coding protein_coding 10.23895 5.501158 14.36573 0.4380758 0.445648 1.383208 3.9563809 2.76518152 5.1691794 0.60738489 0.46546639 0.9001414 0.40532083 0.492500000 0.36076667 -0.13173333 3.718246e-01 6.369714e-08 FALSE TRUE
ENST00000619706 ENSG00000111877 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM9 protein_coding protein_coding 10.23895 5.501158 14.36573 0.4380758 0.445648 1.383208 2.8351145 1.13028166 4.7776514 0.18874820 0.32088359 2.0699279 0.25917917 0.212933333 0.33200000 0.11906667 2.421596e-01 6.369714e-08 FALSE TRUE
MSTRG.28883.1 ENSG00000111877 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM9 protein_coding   10.23895 5.501158 14.36573 0.4380758 0.445648 1.383208 0.6899220 0.82230852 0.7444289 0.09481540 0.06275012 -0.1417335 0.08635000 0.148933333 0.05166667 -0.09726667 6.277013e-06 6.369714e-08 FALSE TRUE
MSTRG.28883.5 ENSG00000111877 HEK293_OSMI2_2hA HEK293_TMG_2hB MCM9 protein_coding   10.23895 5.501158 14.36573 0.4380758 0.445648 1.383208 0.7874528 0.04677319 1.8031384 0.02343149 0.23036694 4.9971354 0.05490833 0.008433333 0.12573333 0.11730000 6.369714e-08 6.369714e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111877 E001 11.1199058 0.0018433628 3.099451e-10 5.031590e-09 6 118789218 118789361 144 - 0.741 1.403 2.433
ENSG00000111877 E002 5.7043571 0.1026265117 7.010541e-04 2.902881e-03 6 118789362 118789428 67 - 0.470 1.161 2.788
ENSG00000111877 E003 1.2554346 0.0111148133 2.126858e-01 3.417154e-01 6 118813442 118813454 13 - 0.251 0.500 1.465
ENSG00000111877 E004 375.0295432 0.0081071643 8.817635e-07 7.409512e-06 6 118813455 118815216 1762 - 2.456 2.689 0.775
ENSG00000111877 E005 170.1961416 0.0004201327 4.154239e-01 5.588157e-01 6 118815217 118815876 660 - 2.194 2.215 0.070
ENSG00000111877 E006 101.0459183 0.0003517092 1.956756e-04 9.454020e-04 6 118815877 118816180 304 - 2.004 1.903 -0.339
ENSG00000111877 E007 47.3676963 0.0084767934 4.918123e-03 1.570241e-02 6 118816181 118816294 114 - 1.695 1.530 -0.561
ENSG00000111877 E008 46.1070768 0.0007759040 1.209739e-01 2.213308e-01 6 118826147 118826292 146 - 1.599 1.728 0.436
ENSG00000111877 E009 50.4686906 0.0021584721 6.195797e-01 7.369577e-01 6 118826782 118826864 83 - 1.659 1.731 0.245
ENSG00000111877 E010 50.0530195 0.0040138807 8.675120e-01 9.188225e-01 6 118827927 118828013 87 - 1.666 1.700 0.113
ENSG00000111877 E011 54.4412098 0.0004085436 7.891210e-01 8.650035e-01 6 118828014 118828130 117 - 1.702 1.732 0.103
ENSG00000111877 E012 0.5827671 0.1126146706 2.519798e-01 3.882999e-01 6 118829028 118829047 20 - 0.251 0.000 -10.447
ENSG00000111877 E013 68.5599490 0.0005790790 8.355215e-01 8.971320e-01 6 118829048 118829250 203 - 1.790 1.843 0.179
ENSG00000111877 E014 0.0000000       6 118829251 118829253 3 -      
ENSG00000111877 E015 69.7984033 0.0039916642 5.520990e-01 6.814478e-01 6 118856371 118856545 175 - 1.814 1.822 0.027
ENSG00000111877 E016 13.7474487 0.0013608514 4.522020e-01 5.930820e-01 6 118894027 118894356 330 - 1.144 1.111 -0.118
ENSG00000111877 E017 22.9567712 0.0012676039 1.954429e-03 7.085108e-03 6 118910597 118911649 1053 - 1.246 1.517 0.939
ENSG00000111877 E018 65.4479431 0.0019114416 4.504255e-02 1.002782e-01 6 118911650 118911769 120 - 1.806 1.745 -0.207
ENSG00000111877 E019 0.7750806 0.0193231435 6.754725e-01 7.807485e-01 6 118911770 118913294 1525 - 0.251 0.188 -0.533
ENSG00000111877 E020 63.5308958 0.0003861071 2.321168e-01 3.649462e-01 6 118913295 118913420 126 - 1.779 1.766 -0.044
ENSG00000111877 E021 79.6269454 0.0003240548 1.672955e-01 2.846768e-01 6 118917561 118917761 201 - 1.877 1.863 -0.049
ENSG00000111877 E022 1.3349319 0.0099408233 2.082232e-01 3.363587e-01 6 118917762 118922004 4243 - 0.409 0.188 -1.535
ENSG00000111877 E023 50.1790057 0.0006222685 1.140219e-02 3.212203e-02 6 118922005 118922086 82 - 1.704 1.607 -0.327
ENSG00000111877 E024 76.0525389 0.0010129426 2.583253e-02 6.359589e-02 6 118923811 118923962 152 - 1.868 1.808 -0.202
ENSG00000111877 E025 73.2303336 0.0059332840 4.732266e-02 1.044048e-01 6 118923963 118924127 165 - 1.857 1.779 -0.262
ENSG00000111877 E026 47.6802906 0.0004623103 2.950626e-03 1.011833e-02 6 118931420 118931489 70 - 1.690 1.565 -0.426
ENSG00000111877 E027 75.3850720 0.0005430336 1.489014e-05 9.511250e-05 6 118931490 118931738 249 - 1.891 1.732 -0.534
ENSG00000111877 E028 16.8012021 0.0011110533 3.490662e-03 1.169813e-02 6 118932607 118932740 134 - 1.275 1.031 -0.871
ENSG00000111877 E029 0.1472490 0.0432497016 1.000000e+00   6 118934390 118934476 87 - 0.078 0.000 -8.450
ENSG00000111877 E030 28.5864907 0.0006681463 1.698677e-06 1.342185e-05 6 118934891 118935162 272 - 1.515 1.178 -1.173