ENSG00000111850

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229570 ENSG00000111850 HEK293_OSMI2_2hA HEK293_TMG_2hB SMIM8 protein_coding protein_coding 4.639313 2.864128 5.664239 0.3184493 0.4432372 0.9813024 2.11637103 1.50993595 2.9976848 0.38316417 0.07383078 0.9846429 0.47268333 0.513833333 0.53740000 0.02356667 0.964722813 0.003797446 FALSE  
ENST00000369570 ENSG00000111850 HEK293_OSMI2_2hA HEK293_TMG_2hB SMIM8 protein_coding retained_intron 4.639313 2.864128 5.664239 0.3184493 0.4432372 0.9813024 0.19814395 0.02680565 0.3312914 0.01701751 0.03624286 3.2130049 0.05258333 0.009366667 0.05970000 0.05033333 0.023873446 0.003797446    
ENST00000369572 ENSG00000111850 HEK293_OSMI2_2hA HEK293_TMG_2hB SMIM8 protein_coding processed_transcript 4.639313 2.864128 5.664239 0.3184493 0.4432372 0.9813024 0.08106279 0.17798117 0.0000000 0.08926835 0.00000000 -4.2325163 0.02480833 0.062666667 0.00000000 -0.06266667 0.045695114 0.003797446 FALSE  
ENST00000448282 ENSG00000111850 HEK293_OSMI2_2hA HEK293_TMG_2hB SMIM8 protein_coding nonsense_mediated_decay 4.639313 2.864128 5.664239 0.3184493 0.4432372 0.9813024 0.23199184 0.02008459 0.4222331 0.02008459 0.05220022 3.8447129 0.04773333 0.008266667 0.07623333 0.06796667 0.003797446 0.003797446    
MSTRG.28612.5 ENSG00000111850 HEK293_OSMI2_2hA HEK293_TMG_2hB SMIM8 protein_coding   4.639313 2.864128 5.664239 0.3184493 0.4432372 0.9813024 1.56640912 1.01537579 1.3094727 0.27178519 0.74608518 0.3638087 0.30402917 0.372266667 0.21280000 -0.15946667 0.714504551 0.003797446 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111850 E001 0.4031496 0.0290826185 0.0937633771 0.181005854 6 87322583 87322587 5 + 0.000 0.263 11.271
ENSG00000111850 E002 0.4031496 0.0290826185 0.0937633771 0.181005854 6 87322588 87322592 5 + 0.000 0.263 13.499
ENSG00000111850 E003 1.4467039 0.0100747657 0.6943288402 0.795188648 6 87322593 87322595 3 + 0.357 0.426 0.387
ENSG00000111850 E004 2.0702691 0.0079412480 0.9663065076 0.982851040 6 87322596 87322598 3 + 0.482 0.489 0.031
ENSG00000111850 E005 5.3593300 0.0030252735 0.2454739412 0.380602538 6 87322599 87322604 6 + 0.867 0.713 -0.614
ENSG00000111850 E006 5.8752732 0.0027950497 0.2469978404 0.382405098 6 87322605 87322608 4 + 0.896 0.746 -0.587
ENSG00000111850 E007 11.8148089 0.0015960214 0.2352812734 0.368694581 6 87322609 87322619 11 + 1.068 1.180 0.403
ENSG00000111850 E008 17.5878885 0.0012688905 0.7276488314 0.820272459 6 87322620 87322631 12 + 1.292 1.266 -0.091
ENSG00000111850 E009 17.5878885 0.0012688905 0.7276488314 0.820272459 6 87322632 87322632 1 + 1.292 1.266 -0.091
ENSG00000111850 E010 0.2924217 0.0294278656 0.4007445370   6 87322633 87322878 246 + 0.179 0.000 -13.281
ENSG00000111850 E011 0.2955422 0.0274445445 0.7177553349   6 87330692 87330712 21 + 0.098 0.151 0.707
ENSG00000111850 E012 0.4470576 0.0226867647 0.9323303175 0.961367161 6 87330713 87330950 238 + 0.179 0.151 -0.293
ENSG00000111850 E013 1.0017226 0.0138909169 0.5502995357 0.679949624 6 87332984 87333170 187 + 0.246 0.352 0.710
ENSG00000111850 E014 45.6120630 0.0007326455 0.2441379469 0.379061604 6 87337009 87337166 158 + 1.646 1.703 0.193
ENSG00000111850 E015 57.4386649 0.0006227327 0.7399259963 0.829501462 6 87340116 87340282 167 + 1.762 1.775 0.047
ENSG00000111850 E016 33.7142630 0.0007417600 0.9582308198 0.977815962 6 87340283 87340337 55 + 1.542 1.545 0.011
ENSG00000111850 E017 24.8929078 0.0009347060 0.6281949199 0.743782377 6 87340338 87340369 32 + 1.427 1.393 -0.116
ENSG00000111850 E018 61.7340047 0.0006316544 0.4590686312 0.599303837 6 87340370 87341225 856 + 1.788 1.818 0.104
ENSG00000111850 E019 50.6980475 0.0007221131 0.8218980902 0.887694920 6 87341226 87342329 1104 + 1.726 1.717 -0.031
ENSG00000111850 E020 0.5901540 0.0192823151 0.6030712124 0.723921607 6 87371593 87371712 120 + 0.246 0.151 -0.877
ENSG00000111850 E021 0.4375944 0.0249434297 0.2069566446 0.334895603 6 87374688 87375461 774 + 0.246 0.000 -13.812
ENSG00000111850 E022 2.8993598 0.0458196504 0.7965755025 0.870167734 6 87375462 87375710 249 + 0.608 0.545 -0.281
ENSG00000111850 E023 1.1050531 0.0121260608 0.1754836360 0.295297400 6 87375711 87378602 2892 + 0.403 0.151 -1.874
ENSG00000111850 E024 0.1817044 0.0458698562 0.2913283788   6 87391780 87391835 56 + 0.000 0.151 12.500
ENSG00000111850 E025 0.0000000       6 87391836 87391877 42 +      
ENSG00000111850 E026 3.4729538 0.0164507554 0.5914078843 0.714188410 6 87392725 87392842 118 + 0.683 0.593 -0.390
ENSG00000111850 E027 5.4713967 0.0031143836 0.0003268179 0.001488011 6 87397122 87398242 1121 + 0.961 0.426 -2.290
ENSG00000111850 E028 3.8866123 0.0041900316 0.8405589920 0.900482806 6 87398243 87398377 135 + 0.683 0.712 0.123
ENSG00000111850 E029 2.7667854 0.0054267056 0.9394762972 0.966006850 6 87399434 87399437 4 + 0.580 0.592 0.056
ENSG00000111850 E030 4.8359086 0.0036155063 0.6561100261 0.765825516 6 87399438 87399749 312 + 0.747 0.806 0.238