ENSG00000111837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354489 ENSG00000111837 HEK293_OSMI2_2hA HEK293_TMG_2hB MAK protein_coding protein_coding 0.7125031 0.4791649 1.130751 0.08876571 0.1004346 1.221591 0.04479522 0.000000000 0.0000000 0.000000000 0.0000000 0.0000000 0.05776667 0.0000000 0.0000000 0.00000000   0.01525514 FALSE TRUE
ENST00000474039 ENSG00000111837 HEK293_OSMI2_2hA HEK293_TMG_2hB MAK protein_coding protein_coding 0.7125031 0.4791649 1.130751 0.08876571 0.1004346 1.221591 0.29978632 0.259760647 0.2186047 0.058562073 0.2186047 -0.2388249 0.49915417 0.6221667 0.1795667 -0.44260000 0.26688578 0.01525514 FALSE TRUE
ENST00000536370 ENSG00000111837 HEK293_OSMI2_2hA HEK293_TMG_2hB MAK protein_coding protein_coding 0.7125031 0.4791649 1.130751 0.08876571 0.1004346 1.221591 0.10318899 0.090043515 0.2619680 0.046241228 0.1309848 1.4428093 0.15098750 0.1592333 0.2128667 0.05363333 0.98076948 0.01525514 FALSE TRUE
ENST00000538030 ENSG00000111837 HEK293_OSMI2_2hA HEK293_TMG_2hB MAK protein_coding nonsense_mediated_decay 0.7125031 0.4791649 1.130751 0.08876571 0.1004346 1.221591 0.11546233 0.008448296 0.4269833 0.008448296 0.1410270 4.5660185 0.11524583 0.0138000 0.3853667 0.37156667 0.01525514 0.01525514 TRUE TRUE
ENST00000676116 ENSG00000111837 HEK293_OSMI2_2hA HEK293_TMG_2hB MAK protein_coding protein_coding 0.7125031 0.4791649 1.130751 0.08876571 0.1004346 1.221591 0.12917944 0.095317533 0.2231949 0.063047195 0.1375630 1.1467907 0.15115417 0.1630333 0.2222000 0.05916667 1.00000000 0.01525514 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111837 E001 0.0000000       6 10762723 10762724 2 -      
ENSG00000111837 E002 0.8052565 0.157693274 0.800926844 0.873119765 6 10762725 10762798 74 - 0.228 0.284 0.421
ENSG00000111837 E003 21.2177229 0.033502712 0.000725828 0.002991834 6 10762799 10764195 1397 - 1.163 1.531 1.282
ENSG00000111837 E004 1.9646483 0.213429169 0.264828501 0.402824332 6 10764196 10764200 5 - 0.333 0.652 1.597
ENSG00000111837 E005 8.7863613 0.099472887 0.888134974 0.932493731 6 10764201 10764606 406 - 0.947 1.047 0.372
ENSG00000111837 E006 2.9257618 0.005738721 0.769187464 0.850885641 6 10770111 10770230 120 - 0.548 0.626 0.348
ENSG00000111837 E007 0.0000000       6 10773034 10773108 75 -      
ENSG00000111837 E008 8.0090146 0.002447768 0.802799067 0.874414909 6 10775328 10775459 132 - 0.922 0.988 0.247
ENSG00000111837 E009 0.0000000       6 10779326 10779497 172 -      
ENSG00000111837 E010 8.6047698 0.002117015 0.349482673 0.493683918 6 10784424 10784572 149 - 0.989 0.922 -0.248
ENSG00000111837 E011 0.2934659 0.028544913 0.661042837   6 10784820 10784924 105 - 0.090 0.164 0.997
ENSG00000111837 E012 8.8432675 0.019792194 0.526399059 0.659633571 6 10791675 10791847 173 - 0.989 0.947 -0.155
ENSG00000111837 E013 14.1693633 0.007095998 0.031465832 0.074817792 6 10795998 10796309 312 - 1.215 1.048 -0.603
ENSG00000111837 E014 5.7806555 0.003106495 0.006141640 0.018982220 6 10801892 10802059 168 - 0.922 0.575 -1.416
ENSG00000111837 E015 6.3650420 0.005905346 0.245239659 0.380320217 6 10803720 10803891 172 - 0.898 0.783 -0.448
ENSG00000111837 E016 4.7396641 0.186434654 0.851599497 0.907976914 6 10808810 10808942 133 - 0.748 0.750 0.007
ENSG00000111837 E017 3.1335036 0.227602347 0.939271966 0.965852812 6 10813644 10813723 80 - 0.576 0.636 0.263
ENSG00000111837 E018 3.5388196 0.005117639 0.414484213 0.557900280 6 10817850 10817971 122 - 0.670 0.576 -0.414
ENSG00000111837 E019 3.9817246 0.004352505 0.428247796 0.571042275 6 10818886 10818940 55 - 0.711 0.626 -0.362
ENSG00000111837 E020 8.5047634 0.002544670 0.259746118 0.397201408 6 10830548 10830877 330 - 0.989 0.898 -0.340
ENSG00000111837 E021 0.1482932 0.041073600 0.271665277   6 10838342 10838481 140 - 0.000 0.164 9.640
ENSG00000111837 E022 0.6727692 0.033940851 0.561425183 0.689245748 6 10838482 10838502 21 - 0.165 0.283 0.999
ENSG00000111837 E023 3.1816649 0.005362593 0.603255866 0.724079032 6 10838503 10838553 51 - 0.626 0.575 -0.222