ENSG00000111802

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378198 ENSG00000111802 HEK293_OSMI2_2hA HEK293_TMG_2hB TDP2 protein_coding protein_coding 28.68162 13.86302 44.4421 1.344588 1.427341 1.679969 26.7560853 12.53286 41.8835906 1.3818120 1.2920507 1.7398636 0.9133375 0.9024 0.9425333 0.04013333 0.3168541093 0.0001162212 FALSE  
ENST00000480495 ENSG00000111802 HEK293_OSMI2_2hA HEK293_TMG_2hB TDP2 protein_coding processed_transcript 28.68162 13.86302 44.4421 1.344588 1.427341 1.679969 0.8071007 1.03754 0.7268688 0.1992909 0.1528301 -0.5075251 0.0470125 0.0756 0.0162000 -0.05940000 0.0001162212 0.0001162212 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111802 E001 389.3859710 0.0054751161 3.779840e-07 3.424415e-06 6 24649979 24650544 566 - 2.481 2.682 0.669
ENSG00000111802 E002 360.1885681 0.0003538267 1.143756e-03 4.450220e-03 6 24650545 24650914 370 - 2.488 2.576 0.293
ENSG00000111802 E003 181.5276313 0.0012621632 2.223152e-01 3.531701e-01 6 24650915 24650986 72 - 2.222 2.201 -0.068
ENSG00000111802 E004 188.9138929 0.0002178046 3.905947e-03 1.288002e-02 6 24650987 24651069 83 - 2.252 2.191 -0.203
ENSG00000111802 E005 282.3463131 0.0002615511 3.902557e-04 1.737020e-03 6 24652983 24653153 171 - 2.423 2.361 -0.208
ENSG00000111802 E006 0.1482932 0.0411597534 1.564214e-01   6 24654378 24654411 34 - 0.000 0.196 11.111
ENSG00000111802 E007 214.9801421 0.0002330741 8.387368e-04 3.397395e-03 6 24654412 24654530 119 - 2.308 2.239 -0.230
ENSG00000111802 E008 175.9263863 0.0002330147 4.773265e-02 1.051440e-01 6 24657812 24657903 92 - 2.214 2.178 -0.122
ENSG00000111802 E009 256.9453113 0.0034811061 2.182995e-04 1.042243e-03 6 24658561 24658734 174 - 2.396 2.280 -0.387
ENSG00000111802 E010 3.3257804 0.0046667689 8.737033e-01 9.228300e-01 6 24658735 24659172 438 - 0.597 0.588 -0.043
ENSG00000111802 E011 5.0017158 0.0095182360 2.182952e-04 1.042243e-03 6 24665987 24666118 132 - 0.532 1.053 2.101
ENSG00000111802 E012 12.6595843 0.0299158257 9.795149e-07 8.140871e-06 6 24666119 24666525 407 - 0.828 1.435 2.197
ENSG00000111802 E013 205.2754112 0.0049401824 5.744662e-01 7.002734e-01 6 24666526 24666611 86 - 2.272 2.264 -0.028
ENSG00000111802 E014 160.0880987 0.0083493288 7.367479e-01 8.271484e-01 6 24666698 24666930 233 - 2.163 2.157 -0.022