ENSG00000111790

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229395 ENSG00000111790 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR1OP2 protein_coding protein_coding 20.7261 6.909621 36.79672 0.815287 0.6385538 2.411204 4.958966 1.9772484 9.935758 0.24864827 0.4210331 2.323309 0.24323333 0.28740000 0.26983333 -0.01756667 8.461794e-01 6.807418e-05 FALSE TRUE
ENST00000327214 ENSG00000111790 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR1OP2 protein_coding protein_coding 20.7261 6.909621 36.79672 0.815287 0.6385538 2.411204 1.616058 0.2447359 1.917403 0.08665906 0.1062723 2.919584 0.06677917 0.03506667 0.05220000 0.01713333 4.805134e-01 6.807418e-05 FALSE TRUE
ENST00000395941 ENSG00000111790 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR1OP2 protein_coding retained_intron 20.7261 6.909621 36.79672 0.815287 0.6385538 2.411204 2.183194 0.1291180 3.987223 0.06548237 0.5175253 4.844617 0.07036250 0.01823333 0.10796667 0.08973333 6.807418e-05 6.807418e-05 FALSE TRUE
ENST00000538172 ENSG00000111790 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR1OP2 protein_coding retained_intron 20.7261 6.909621 36.79672 0.815287 0.6385538 2.411204 1.591088 0.2425143 2.772924 0.06069297 0.1532083 3.462165 0.08000417 0.03430000 0.07533333 0.04103333 1.528265e-02 6.807418e-05   FALSE
ENST00000546072 ENSG00000111790 HEK293_OSMI2_2hA HEK293_TMG_2hB FGFR1OP2 protein_coding protein_coding 20.7261 6.909621 36.79672 0.815287 0.6385538 2.411204 10.273690 4.2571158 18.183407 0.49151232 0.2141630 2.092083 0.53322500 0.61643333 0.49466667 -0.12176667 4.934008e-03 6.807418e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111790 E001 11.3984983 0.0017576430 8.658134e-03 2.542796e-02 12 26938470 26938480 11 + 0.936 1.220 1.032
ENSG00000111790 E002 16.0301952 0.0011660180 9.172409e-02 1.778211e-01 12 26938481 26938483 3 + 1.107 1.272 0.585
ENSG00000111790 E003 36.5262146 0.0008865845 5.751447e-01 7.008385e-01 12 26938484 26938496 13 + 1.477 1.517 0.136
ENSG00000111790 E004 38.0835353 0.0006025279 4.488852e-01 5.901005e-01 12 26938497 26938499 3 + 1.492 1.544 0.179
ENSG00000111790 E005 129.6698415 0.0003760879 3.879599e-01 5.320726e-01 12 26938500 26938710 211 + 2.018 2.050 0.109
ENSG00000111790 E006 0.1451727 0.0437692257 1.000000e+00   12 26953549 26953706 158 + 0.060 0.001 -6.961
ENSG00000111790 E007 140.5286228 0.0012102426 9.690450e-01 9.846320e-01 12 26954145 26954293 149 + 2.059 2.055 -0.013
ENSG00000111790 E008 154.4030331 0.0022615725 7.654809e-01 8.482374e-01 12 26956543 26956660 118 + 2.103 2.088 -0.048
ENSG00000111790 E009 191.8933073 0.0002653132 6.358292e-02 1.326622e-01 12 26957601 26957743 143 + 2.182 2.238 0.187
ENSG00000111790 E010 6.3635243 0.0026755693 1.494732e-01 2.609516e-01 12 26957744 26957971 228 + 0.825 0.584 -1.003
ENSG00000111790 E011 153.3974092 0.0008628428 1.622034e-01 2.779786e-01 12 26960515 26960628 114 + 2.088 2.138 0.168
ENSG00000111790 E012 59.9770338 0.0025551780 3.126479e-04 1.431200e-03 12 26960629 26960846 218 + 1.648 1.850 0.683
ENSG00000111790 E013 96.9848721 0.0004219424 3.122664e-10 5.068363e-09 12 26960996 26963341 2346 + 1.949 1.617 -1.122
ENSG00000111790 E014 104.5884735 0.0013370827 2.410623e-13 6.491617e-12 12 26963342 26963455 114 + 1.987 1.578 -1.383
ENSG00000111790 E015 370.3570618 0.0003547626 1.208215e-01 2.211247e-01 12 26964596 26966650 2055 + 2.472 2.504 0.108