ENSG00000111786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229390 ENSG00000111786 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF9 protein_coding protein_coding 454.3344 701.9828 352.6517 48.51774 8.734414 -0.9931711 423.638 674.1856 320.7825 47.77301 9.376858 -1.071527 0.9239208 0.9601667 0.9094667 -0.0507 4.137429e-09 1.27705e-21 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111786 E001 40.4599879 0.0021512805 6.243149e-17 2.754055e-15 12 120461672 120461692 21 - 0.935 1.671 2.591
ENSG00000111786 E002 69.1279106 0.0003781913 1.830572e-03 6.697108e-03 12 120461693 120461707 15 - 1.674 1.828 0.521
ENSG00000111786 E003 496.7268275 0.0004675447 2.134666e-12 4.962646e-11 12 120461708 120461710 3 - 2.526 2.674 0.491
ENSG00000111786 E004 1030.2363712 0.0009920909 2.794953e-44 1.237139e-41 12 120461711 120461761 51 - 2.727 3.012 0.949
ENSG00000111786 E005 7613.9714076 0.0006926839 4.076187e-22 3.288847e-20 12 120461762 120462162 401 - 3.747 3.845 0.327
ENSG00000111786 E006 96.9299982 0.0053470659 1.903157e-33 4.155055e-31 12 120462163 120463396 1234 - 2.295 1.687 -2.045
ENSG00000111786 E007 3730.6816044 0.0011319295 1.704909e-04 8.372171e-04 12 120463950 120463977 28 - 3.472 3.526 0.179
ENSG00000111786 E008 6714.8157506 0.0002230154 5.697087e-08 6.064824e-07 12 120463978 120464122 145 - 3.744 3.777 0.110
ENSG00000111786 E009 161.3413910 0.0022308162 8.339309e-59 8.185788e-56 12 120464123 120464732 610 - 2.502 1.917 -1.957
ENSG00000111786 E010 32.4522778 0.0039573155 2.544039e-25 2.863699e-23 12 120464733 120464822 90 - 1.864 1.162 -2.413
ENSG00000111786 E011 25.5425683 0.0272241132 4.701244e-12 1.032383e-10 12 120464823 120464875 53 - 1.773 1.063 -2.465
ENSG00000111786 E012 31.1186127 0.0114916834 9.035285e-20 5.582869e-18 12 120464876 120464943 68 - 1.861 1.133 -2.510
ENSG00000111786 E013 108.9701499 0.0012744618 2.405705e-54 1.923011e-51 12 120465139 120465626 488 - 2.334 1.749 -1.962
ENSG00000111786 E014 4816.6573702 0.0002411241 2.609175e-02 6.413156e-02 12 120465627 120465755 129 - 3.643 3.618 -0.086
ENSG00000111786 E015 2384.1182371 0.0013195465 1.670403e-10 2.839161e-09 12 120465756 120465787 32 - 3.408 3.282 -0.419
ENSG00000111786 E016 3265.0479322 0.0031760427 3.251235e-17 1.484185e-15 12 120469422 120469714 293 - 3.611 3.384 -0.756
ENSG00000111786 E017 54.0984101 0.0161434172 1.550897e-29 2.492051e-27 12 120469715 120469748 34 - 2.146 1.223 -3.144
ENSG00000111786 E018 0.8751107 0.2940659797 2.270777e-01 3.589060e-01 12 120470384 120470552 169 - 0.000 0.310 10.209