ENSG00000111785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392837 ENSG00000111785 HEK293_OSMI2_2hA HEK293_TMG_2hB RIC8B protein_coding protein_coding 5.565053 3.145204 7.115159 0.4080511 0.2389405 1.175189 0.6248107 0.2803174 0.7328510 0.05183218 0.1125905 1.3554417 0.1201333 0.09740000 0.10420000 0.00680000 0.91723258 0.02622926 FALSE TRUE
ENST00000392839 ENSG00000111785 HEK293_OSMI2_2hA HEK293_TMG_2hB RIC8B protein_coding protein_coding 5.565053 3.145204 7.115159 0.4080511 0.2389405 1.175189 2.1928351 2.0447154 2.6286479 0.18669542 0.0669276 0.3608603 0.4561750 0.67036667 0.36980000 -0.30056667 0.02622926 0.02622926 FALSE TRUE
ENST00000548914 ENSG00000111785 HEK293_OSMI2_2hA HEK293_TMG_2hB RIC8B protein_coding protein_coding 5.565053 3.145204 7.115159 0.4080511 0.2389405 1.175189 1.3241675 0.4497396 2.0855469 0.29929783 0.1319078 2.1884378 0.1859333 0.12386667 0.29253333 0.16866667 0.34272399 0.02622926 FALSE TRUE
ENST00000550215 ENSG00000111785 HEK293_OSMI2_2hA HEK293_TMG_2hB RIC8B protein_coding nonsense_mediated_decay 5.565053 3.145204 7.115159 0.4080511 0.2389405 1.175189 0.3266747 0.1236733 0.3821542 0.06720787 0.1424361 1.5527099 0.0546125 0.03460000 0.05446667 0.01986667 0.84671314 0.02622926 FALSE FALSE
MSTRG.7939.5 ENSG00000111785 HEK293_OSMI2_2hA HEK293_TMG_2hB RIC8B protein_coding   5.565053 3.145204 7.115159 0.4080511 0.2389405 1.175189 0.4867312 0.1761265 0.5415985 0.11762230 0.1532522 1.5673354 0.0940250 0.04973333 0.07550000 0.02576667 0.77877188 0.02622926 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111785 E001 2.5818468 0.0063635640 4.624169e-01 6.022762e-01 12 106774621 106774639 19 + 0.601 0.495 -0.490
ENSG00000111785 E002 7.4473426 0.0344550083 2.987203e-01 4.401828e-01 12 106774640 106774662 23 + 0.976 0.840 -0.517
ENSG00000111785 E003 7.9632858 0.0475367659 3.567523e-01 5.011468e-01 12 106774663 106774670 8 + 0.999 0.866 -0.499
ENSG00000111785 E004 9.2649188 0.0399926768 2.904325e-01 4.312407e-01 12 106774671 106774681 11 + 1.060 0.915 -0.536
ENSG00000111785 E005 13.9245114 0.0299033197 1.186162e-01 2.179645e-01 12 106774682 106774713 32 + 1.236 1.049 -0.668
ENSG00000111785 E006 15.1132359 0.0238919061 2.453739e-01 3.804754e-01 12 106774714 106774745 32 + 1.248 1.125 -0.439
ENSG00000111785 E007 18.9131700 0.0057000923 3.629252e-02 8.414115e-02 12 106774746 106774829 84 + 1.355 1.189 -0.583
ENSG00000111785 E008 0.1451727 0.0438062300 7.893219e-01   12 106775324 106775425 102 + 0.096 0.000 -10.300
ENSG00000111785 E009 14.2176356 0.0012520670 2.269356e-01 3.587353e-01 12 106783997 106784044 48 + 1.216 1.125 -0.322
ENSG00000111785 E010 0.2998086 0.0285159853 7.219260e-01   12 106797977 106798069 93 + 0.097 0.154 0.772
ENSG00000111785 E011 79.0219551 0.0019083483 1.701264e-01 2.883542e-01 12 106814696 106815304 609 + 1.918 1.881 -0.126
ENSG00000111785 E012 3.1774105 0.0049749002 8.557215e-01 9.107931e-01 12 106822258 106823447 1190 + 0.601 0.644 0.189
ENSG00000111785 E013 37.8345715 0.0053462308 1.651300e-01 2.818729e-01 12 106825726 106825820 95 + 1.616 1.543 -0.247
ENSG00000111785 E014 59.2895941 0.0027376470 1.937994e-02 5.015945e-02 12 106842589 106842817 229 + 1.816 1.716 -0.338
ENSG00000111785 E015 39.1166070 0.0005437671 7.294524e-01 8.216309e-01 12 106843852 106843947 96 + 1.603 1.603 0.002
ENSG00000111785 E016 45.8497667 0.0065795162 4.553963e-01 5.959265e-01 12 106851450 106851594 145 + 1.641 1.707 0.222
ENSG00000111785 E017 49.3094196 0.0006626398 3.541543e-01 4.984244e-01 12 106860268 106860412 145 + 1.675 1.740 0.222
ENSG00000111785 E018 0.4847352 0.2107352446 9.437447e-01 9.686975e-01 12 106868301 106868423 123 + 0.176 0.154 -0.226
ENSG00000111785 E019 10.6133920 0.0016656249 5.372905e-03 1.694294e-02 12 106870823 106870942 120 + 1.152 0.868 -1.047
ENSG00000111785 E020 0.8867284 0.0142300001 2.600245e-01 3.975022e-01 12 106870943 106871505 563 + 0.351 0.154 -1.549
ENSG00000111785 E021 0.4545463 0.6667419470 4.659672e-01 6.055476e-01 12 106873032 106873174 143 + 0.244 0.000 -10.862
ENSG00000111785 E022 1.3953985 0.0140231961 7.519017e-02 1.518366e-01 12 106874481 106874567 87 + 0.476 0.154 -2.224
ENSG00000111785 E023 4.2115028 0.0038272828 1.911020e-01 3.151252e-01 12 106878987 106879125 139 + 0.776 0.600 -0.740
ENSG00000111785 E024 0.4407149 0.0213575799 8.942363e-01 9.363932e-01 12 106879728 106879774 47 + 0.175 0.154 -0.227
ENSG00000111785 E025 7.3994113 0.0028814963 5.994547e-02 1.265136e-01 12 106879775 106879947 173 + 0.998 0.786 -0.811
ENSG00000111785 E026 282.7823269 0.0028384161 2.003880e-07 1.919354e-06 12 106885904 106889316 3413 + 2.388 2.521 0.443