ENSG00000111752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000433083 ENSG00000111752 HEK293_OSMI2_2hA HEK293_TMG_2hB PHC1 protein_coding protein_coding 12.00195 11.5607 13.08201 0.475831 0.8197544 0.1782096 2.8045054 5.2212413 1.8831299 0.34934869 0.4017969 -1.4663799 0.23732917 0.45556667 0.14160000 -0.313966667 6.233927e-06 1.6078e-14 FALSE TRUE
ENST00000540809 ENSG00000111752 HEK293_OSMI2_2hA HEK293_TMG_2hB PHC1 protein_coding retained_intron 12.00195 11.5607 13.08201 0.475831 0.8197544 0.1782096 1.4397328 0.4095217 1.8181857 0.22745698 0.1564094 2.1235954 0.11899167 0.03560000 0.13976667 0.104166667 2.214785e-02 1.6078e-14 FALSE FALSE
ENST00000544916 ENSG00000111752 HEK293_OSMI2_2hA HEK293_TMG_2hB PHC1 protein_coding protein_coding 12.00195 11.5607 13.08201 0.475831 0.8197544 0.1782096 5.1677312 4.7526428 5.3454460 0.68147589 0.5876171 0.1692444 0.42888750 0.40773333 0.41586667 0.008133333 1.000000e+00 1.6078e-14 FALSE TRUE
MSTRG.6777.4 ENSG00000111752 HEK293_OSMI2_2hA HEK293_TMG_2hB PHC1 protein_coding   12.00195 11.5607 13.08201 0.475831 0.8197544 0.1782096 0.6534140 0.6515924 0.5455669 0.07052699 0.1745971 -0.2519821 0.05474167 0.05703333 0.04293333 -0.014100000 7.108103e-01 1.6078e-14 TRUE TRUE
MSTRG.6777.6 ENSG00000111752 HEK293_OSMI2_2hA HEK293_TMG_2hB PHC1 protein_coding   12.00195 11.5607 13.08201 0.475831 0.8197544 0.1782096 0.9294917 0.0000000 2.3197818 0.00000000 0.4134984 7.8640510 0.08065833 0.00000000 0.17963333 0.179633333 1.607800e-14 1.6078e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111752 E001 0.3332198 0.0296062145 1.000000e+00   12 8913896 8913950 55 + 0.119 0.126 0.107
ENSG00000111752 E002 1.7401578 0.0087484727 1.323569e-01 2.373794e-01 12 8914509 8914552 44 + 0.545 0.304 -1.307
ENSG00000111752 E003 1.5929088 0.0085764200 2.083350e-01 3.364888e-01 12 8914553 8914590 38 + 0.504 0.304 -1.115
ENSG00000111752 E004 1.0006785 0.0174023694 4.226179e-01 5.657531e-01 12 8914591 8914596 6 + 0.353 0.224 -0.891
ENSG00000111752 E005 1.6639845 0.0088826371 2.099898e-01 3.385235e-01 12 8914597 8914695 99 + 0.504 0.304 -1.113
ENSG00000111752 E006 1.5210019 0.1927749839 4.786571e-01 6.170816e-01 12 8914696 8914713 18 + 0.460 0.310 -0.859
ENSG00000111752 E007 2.4389634 0.0063077498 4.499552e-01 5.911420e-01 12 8914714 8914730 17 + 0.582 0.481 -0.477
ENSG00000111752 E008 6.8125761 0.0358632854 8.376578e-02 1.654435e-01 12 8914731 8914772 42 + 0.991 0.761 -0.883
ENSG00000111752 E009 6.9178943 0.0401617720 7.128941e-02 1.454636e-01 12 8914773 8914781 9 + 1.005 0.761 -0.936
ENSG00000111752 E010 14.9250080 0.0551215230 3.243937e-02 7.670326e-02 12 8914782 8914827 46 + 1.318 1.044 -0.976
ENSG00000111752 E011 0.3666179 0.0309466204 9.975146e-01 1.000000e+00 12 8915760 8916060 301 + 0.119 0.127 0.110
ENSG00000111752 E012 0.0000000       12 8916061 8916069 9 +      
ENSG00000111752 E013 22.1703535 0.0374702173 6.220202e-02 1.303524e-01 12 8917630 8917654 25 + 1.447 1.261 -0.645
ENSG00000111752 E014 37.9217050 0.0167570476 5.514386e-02 1.182424e-01 12 8917655 8917791 137 + 1.649 1.523 -0.430
ENSG00000111752 E015 44.0303984 0.0005091023 5.189521e-02 1.125388e-01 12 8919756 8919866 111 + 1.693 1.622 -0.241
ENSG00000111752 E016 0.8845503 0.2117608054 9.231594e-01 9.555461e-01 12 8919867 8919873 7 + 0.288 0.297 0.065
ENSG00000111752 E017 0.5169874 0.0203881434 5.637034e-01 6.911449e-01 12 8919874 8919917 44 + 0.119 0.224 1.107
ENSG00000111752 E018 48.9750872 0.0004778736 2.923317e-03 1.003983e-02 12 8920985 8921065 81 + 1.759 1.642 -0.396
ENSG00000111752 E019 43.0911995 0.0005381948 2.356712e-09 3.261062e-08 12 8921601 8921750 150 + 1.773 1.483 -0.989
ENSG00000111752 E020 27.9167604 0.0007145453 1.151176e-02 3.237681e-02 12 8922633 8922638 6 + 1.526 1.392 -0.464
ENSG00000111752 E021 28.1964080 0.0007278408 1.823410e-02 4.764157e-02 12 8922639 8922656 18 + 1.526 1.403 -0.423
ENSG00000111752 E022 39.2184941 0.0044133941 1.681361e-03 6.223429e-03 12 8922657 8922732 76 + 1.684 1.516 -0.575
ENSG00000111752 E023 20.9299656 0.0010884799 1.484030e-01 2.595049e-01 12 8922733 8922743 11 + 1.378 1.299 -0.275
ENSG00000111752 E024 22.5583870 0.0065530991 2.129434e-01 3.419987e-01 12 8922744 8922788 45 + 1.406 1.335 -0.245
ENSG00000111752 E025 19.7650918 0.0181713915 5.981013e-02 1.262884e-01 12 8930435 8930611 177 + 1.390 1.230 -0.560
ENSG00000111752 E026 2.9173544 0.1857294542 8.715045e-01 9.213439e-01 12 8930612 8930672 61 + 0.583 0.580 -0.017
ENSG00000111752 E027 9.9656442 0.0110664413 3.136540e-01 4.562748e-01 12 8930673 8930915 243 + 1.078 0.991 -0.318
ENSG00000111752 E028 10.3741070 0.0111904456 1.872593e-01 3.102868e-01 12 8930916 8930927 12 + 1.111 0.991 -0.438
ENSG00000111752 E029 28.8147240 0.0007225946 8.571528e-03 2.521859e-02 12 8932563 8932813 251 + 1.542 1.403 -0.477
ENSG00000111752 E030 4.6330852 0.0036219999 5.919133e-01 7.145801e-01 12 8932814 8932831 18 + 0.779 0.732 -0.192
ENSG00000111752 E031 10.9067596 0.0282212775 3.856255e-01 5.298070e-01 12 8932832 8933063 232 + 1.121 1.033 -0.317
ENSG00000111752 E032 14.6434051 0.0234347081 5.028607e-02 1.096724e-01 12 8933064 8933206 143 + 1.283 1.086 -0.698
ENSG00000111752 E033 15.0047480 0.0071028710 1.406234e-01 2.488736e-01 12 8933207 8933254 48 + 1.254 1.142 -0.396
ENSG00000111752 E034 28.4056925 0.0007187816 6.616242e-02 1.369821e-01 12 8933255 8933306 52 + 1.510 1.421 -0.307
ENSG00000111752 E035 33.2505864 0.0006383135 3.548219e-02 8.258079e-02 12 8933307 8933321 15 + 1.583 1.487 -0.328
ENSG00000111752 E036 42.1994181 0.0005601512 1.585002e-02 4.240018e-02 12 8933322 8933350 29 + 1.684 1.585 -0.336
ENSG00000111752 E037 8.8129659 0.0389352017 4.520464e-03 1.460093e-02 12 8933537 8933864 328 + 1.142 0.763 -1.426
ENSG00000111752 E038 89.9131297 0.0003799805 1.154226e-02 3.244764e-02 12 8933865 8934012 148 + 1.988 1.925 -0.212
ENSG00000111752 E039 105.3175981 0.0003051177 1.898942e-02 4.930971e-02 12 8934267 8934478 212 + 2.052 2.003 -0.164
ENSG00000111752 E040 60.9461952 0.0004112420 5.700373e-02 1.214688e-01 12 8935124 8935238 115 + 1.821 1.767 -0.184
ENSG00000111752 E041 59.4781905 0.0003971003 5.978337e-01 7.195319e-01 12 8936856 8936964 109 + 1.778 1.784 0.020
ENSG00000111752 E042 1.2639554 0.0105597862 1.551342e-01 2.685732e-01 12 8936965 8936975 11 + 0.460 0.224 -1.478
ENSG00000111752 E043 89.0418842 0.0011070158 5.199277e-01 6.539770e-01 12 8937176 8937326 151 + 1.922 1.976 0.183
ENSG00000111752 E044 62.0725903 0.0048459812 1.889883e-01 3.124794e-01 12 8937829 8938060 232 + 1.740 1.840 0.338
ENSG00000111752 E045 11.9628195 0.0015482221 8.049518e-01 8.758871e-01 12 8939305 8939460 156 + 1.089 1.141 0.185
ENSG00000111752 E046 9.6605411 0.0034239610 6.984292e-04 2.893458e-03 12 8939461 8939564 104 + 0.779 1.181 1.498
ENSG00000111752 E047 59.2348628 0.0126942082 1.776391e-07 1.719807e-06 12 8939565 8939728 164 + 1.526 1.927 1.358
ENSG00000111752 E048 93.1793487 0.0072438620 1.526186e-09 2.186922e-08 12 8939729 8939822 94 + 1.752 2.111 1.208
ENSG00000111752 E049 78.8660805 0.0023868714 4.111889e-12 9.115200e-11 12 8939823 8939870 48 + 1.687 2.038 1.181
ENSG00000111752 E050 108.9249917 0.0127969794 8.485284e-07 7.157539e-06 12 8939871 8940575 705 + 1.833 2.171 1.134
ENSG00000111752 E051 54.9166570 0.0189107793 1.797797e-03 6.592480e-03 12 8940576 8941467 892 + 1.573 1.864 0.988