ENSG00000111737

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229340 ENSG00000111737 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB35 protein_coding protein_coding 28.57099 43.72703 22.61492 2.20318 0.839141 -0.9509426 22.625963 38.309734 15.857151 1.680595 0.1011138 -1.2720444 0.7632000 0.8776000 0.7031333 -0.1744667 0.004702932 0.003761726 FALSE TRUE
ENST00000543364 ENSG00000111737 HEK293_OSMI2_2hA HEK293_TMG_2hB RAB35 protein_coding processed_transcript 28.57099 43.72703 22.61492 2.20318 0.839141 -0.9509426 5.767342 5.174922 6.631169 1.290217 0.8039371 0.3571149 0.2301333 0.1168667 0.2913667 0.1745000 0.003761726 0.003761726   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111737 E001 1824.7046378 0.0018489690 1.142185e-09 1.675183e-08 12 120095099 120096365 1267 - 3.101 3.231 0.432
ENSG00000111737 E002 1184.5386536 0.0002051171 1.141021e-11 2.352411e-10 12 120096366 120096903 538 - 2.935 3.038 0.343
ENSG00000111737 E003 623.8834511 0.0001061453 4.297362e-03 1.397635e-02 12 120096904 120097245 342 - 2.686 2.751 0.215
ENSG00000111737 E004 242.7351316 0.0001992443 2.763158e-01 4.157650e-01 12 120097246 120097265 20 - 2.291 2.338 0.156
ENSG00000111737 E005 474.1244523 0.0001954645 7.797570e-01 8.584269e-01 12 120097266 120097373 108 - 2.597 2.621 0.079
ENSG00000111737 E006 571.9908862 0.0001529792 3.317452e-05 1.951805e-04 12 120098811 120098935 125 - 2.733 2.683 -0.167
ENSG00000111737 E007 1.9510204 0.1157389286 3.942800e-02 8.997141e-02 12 120098948 120099029 82 - 0.703 0.306 -1.982
ENSG00000111737 E008 461.3173160 0.0006184390 8.011854e-09 1.005480e-07 12 120099030 120099106 77 - 2.676 2.575 -0.334
ENSG00000111737 E009 371.3270374 0.0002336619 2.687261e-14 8.291424e-13 12 120099107 120099154 48 - 2.607 2.471 -0.452
ENSG00000111737 E010 5.6315946 0.0029641064 3.283029e-01 4.717858e-01 12 120099243 120099462 220 - 0.850 0.732 -0.466
ENSG00000111737 E011 430.9193113 0.0009163573 5.006894e-12 1.094934e-10 12 120103826 120103945 120 - 2.671 2.536 -0.452
ENSG00000111737 E012 154.8786548 0.0031967617 4.806815e-07 4.265677e-06 12 120103946 120103949 4 - 2.260 2.076 -0.613
ENSG00000111737 E013 222.5956451 0.0024641387 2.179251e-05 1.339256e-04 12 120108417 120108467 51 - 2.378 2.252 -0.423
ENSG00000111737 E014 0.8502072 0.0143049305 5.816618e-01 7.061777e-01 12 120108592 120108703 112 - 0.304 0.212 -0.689
ENSG00000111737 E015 175.9869256 0.0052101797 2.884661e-02 6.969741e-02 12 120116599 120118986 2388 - 2.242 2.164 -0.262