ENSG00000111731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333957 ENSG00000111731 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD5 protein_coding protein_coding 10.86901 2.874053 17.43777 0.1831917 0.4011627 2.596873 6.8182602 2.0719781 10.8016025 0.06680242 0.8219829 2.3765536 0.63432917 0.72400000 0.61990000 -0.10410000 4.299503e-01 4.344146e-07 FALSE TRUE
ENST00000446597 ENSG00000111731 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD5 protein_coding protein_coding 10.86901 2.874053 17.43777 0.1831917 0.4011627 2.596873 0.5322307 0.3167698 0.6239977 0.09358675 0.6239977 0.9562028 0.07981667 0.11150000 0.03443333 -0.07706667 1.789378e-01 4.344146e-07 FALSE TRUE
ENST00000539615 ENSG00000111731 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD5 protein_coding protein_coding 10.86901 2.874053 17.43777 0.1831917 0.4011627 2.596873 0.1862492 0.2309427 0.0000000 0.10855023 0.0000000 -4.5906181 0.03623333 0.07783333 0.00000000 -0.07783333 4.344146e-07 4.344146e-07 FALSE TRUE
ENST00000542676 ENSG00000111731 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD5 protein_coding protein_coding 10.86901 2.874053 17.43777 0.1831917 0.4011627 2.596873 0.9169307 0.0000000 2.0955710 0.00000000 0.4225629 7.7180677 0.05073333 0.00000000 0.12083333 0.12083333 4.542774e-06 4.344146e-07 FALSE TRUE
ENST00000543888 ENSG00000111731 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD5 protein_coding retained_intron 10.86901 2.874053 17.43777 0.1831917 0.4011627 2.596873 0.7387398 0.1933294 0.4507431 0.05708096 0.1225771 1.1801441 0.08721667 0.06520000 0.02613333 -0.03906667 2.303505e-01 4.344146e-07   FALSE
MSTRG.6949.5 ENSG00000111731 HEK293_OSMI2_2hA HEK293_TMG_2hB C2CD5 protein_coding   10.86901 2.874053 17.43777 0.1831917 0.4011627 2.596873 0.8003049 0.0000000 1.7904116 0.00000000 0.4898382 7.4921829 0.04495833 0.00000000 0.10313333 0.10313333 2.370278e-04 4.344146e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111731 E001 206.0406331 0.0128063191 1.446055e-14 4.655069e-13 12 22448583 22449544 962 - 2.057 2.537 1.605
ENSG00000111731 E002 30.5970926 0.0062758944 4.134226e-06 2.996239e-05 12 22449545 22449580 36 - 1.265 1.678 1.424
ENSG00000111731 E003 41.4869084 0.0005325827 6.063524e-09 7.795308e-08 12 22449581 22449655 75 - 1.392 1.804 1.406
ENSG00000111731 E004 84.1345832 0.0058410792 5.511739e-03 1.731761e-02 12 22449656 22449814 159 - 1.748 1.962 0.720
ENSG00000111731 E005 64.2115795 0.0139674117 6.465784e-02 1.344725e-01 12 22449815 22449891 77 - 1.636 1.833 0.667
ENSG00000111731 E006 67.0659141 0.0059113950 1.394929e-02 3.810601e-02 12 22453896 22454042 147 - 1.652 1.859 0.700
ENSG00000111731 E007 83.8092677 0.0005043372 5.279481e-01 6.608840e-01 12 22456971 22457161 191 - 1.770 1.853 0.279
ENSG00000111731 E008 12.8481582 0.0013641872 5.317445e-01 6.641394e-01 12 22458484 22458555 72 - 1.011 0.976 -0.129
ENSG00000111731 E009 8.2551950 0.0022205354 3.589426e-01 5.032831e-01 12 22458556 22458585 30 - 0.805 0.976 0.654
ENSG00000111731 E010 3.0194267 0.0501642828 7.661702e-02 1.540807e-01 12 22458586 22458864 279 - 0.419 0.785 1.647
ENSG00000111731 E011 19.9198992 0.0010851822 5.003896e-01 6.366465e-01 12 22459492 22459542 51 - 1.187 1.163 -0.087
ENSG00000111731 E012 59.9923281 0.0003853796 8.671082e-01 9.185055e-01 12 22469709 22469795 87 - 1.633 1.692 0.203
ENSG00000111731 E013 31.0400499 0.0006853209 4.047891e-01 5.484899e-01 12 22470824 22470835 12 - 1.345 1.462 0.402
ENSG00000111731 E014 49.4894539 0.0004373428 1.488566e-01 2.601203e-01 12 22470836 22470896 61 - 1.535 1.677 0.485
ENSG00000111731 E015 35.2290542 0.0005932187 7.960920e-01 8.698218e-01 12 22470897 22470911 15 - 1.405 1.474 0.239
ENSG00000111731 E016 54.1802009 0.0004671103 4.050083e-01 5.486854e-01 12 22471399 22471488 90 - 1.583 1.685 0.346
ENSG00000111731 E017 51.0681137 0.0015077536 2.215841e-01 3.522982e-01 12 22471967 22472065 99 - 1.555 1.685 0.440
ENSG00000111731 E018 46.1189177 0.0004811063 6.452149e-01 7.573644e-01 12 22472286 22472347 62 - 1.521 1.601 0.276
ENSG00000111731 E019 0.1472490 0.0434595801 9.904319e-01   12 22472348 22472445 98 - 0.051 0.000 -8.955
ENSG00000111731 E020 47.7332763 0.0010669650 7.134436e-02 1.455647e-01 12 22472744 22472807 64 - 1.517 1.685 0.571
ENSG00000111731 E021 64.4819950 0.0003755778 4.739785e-01 6.128502e-01 12 22474751 22474891 141 - 1.657 1.748 0.309
ENSG00000111731 E022 0.1472490 0.0434595801 9.904319e-01   12 22477262 22477338 77 - 0.051 0.000 -8.955
ENSG00000111731 E023 0.6599951 0.0213315107 1.654542e-04 8.155911e-04 12 22478028 22478312 285 - 0.000 0.641 16.191
ENSG00000111731 E024 72.1002281 0.0003704478 9.011324e-01 9.409500e-01 12 22478313 22478477 165 - 1.712 1.755 0.145
ENSG00000111731 E025 31.7005903 0.0006556983 9.465633e-01 9.704654e-01 12 22482557 22482561 5 - 1.364 1.408 0.149
ENSG00000111731 E026 72.2694810 0.0004032548 2.519754e-02 6.227706e-02 12 22482562 22482743 182 - 1.731 1.645 -0.290
ENSG00000111731 E027 0.4502799 0.0297634428 1.000000e+00 1.000000e+00 12 22484338 22484696 359 - 0.138 0.000 -10.540
ENSG00000111731 E028 39.0440274 0.0005921524 6.054781e-04 2.553335e-03 12 22484697 22484742 46 - 1.490 1.233 -0.894
ENSG00000111731 E029 31.8244551 0.0008063116 6.369621e-03 1.958334e-02 12 22484743 22484754 12 - 1.400 1.187 -0.746
ENSG00000111731 E030 34.6942072 0.0022890699 1.437587e-02 3.907971e-02 12 22484755 22484794 40 - 1.432 1.254 -0.619
ENSG00000111731 E031 48.1129997 0.0004917691 6.388922e-03 1.963376e-02 12 22484795 22484888 94 - 1.567 1.408 -0.548
ENSG00000111731 E032 52.4458827 0.0004837599 2.007704e-04 9.670577e-04 12 22490123 22490218 96 - 1.613 1.378 -0.808
ENSG00000111731 E033 67.2161330 0.0011568481 8.673744e-04 3.499552e-03 12 22493223 22493337 115 - 1.715 1.542 -0.589
ENSG00000111731 E034 0.0000000       12 22502739 22502804 66 -      
ENSG00000111731 E035 59.0176350 0.0015008455 3.167663e-02 7.521518e-02 12 22506711 22506819 109 - 1.651 1.553 -0.335
ENSG00000111731 E036 0.1482932 0.0419488009 6.107137e-02   12 22506820 22506967 148 - 0.000 0.266 14.189
ENSG00000111731 E037 0.1472490 0.0434595801 9.904319e-01   12 22512647 22512679 33 - 0.051 0.000 -8.955
ENSG00000111731 E038 53.7418518 0.0006049598 1.512712e-03 5.677411e-03 12 22513294 22513379 86 - 1.620 1.435 -0.631
ENSG00000111731 E039 62.4530879 0.0011360448 2.647368e-05 1.595571e-04 12 22517986 22518095 110 - 1.691 1.435 -0.872
ENSG00000111731 E040 39.8659632 0.0028278165 8.667441e-03 2.545216e-02 12 22518096 22518137 42 - 1.494 1.311 -0.631
ENSG00000111731 E041 2.8151383 0.0052955141 3.039734e-02 7.274005e-02 12 22519040 22519114 75 - 0.529 0.000 -13.202
ENSG00000111731 E042 3.8105182 0.0040481788 7.440712e-01 8.325338e-01 12 22519115 22519239 125 - 0.574 0.549 -0.116
ENSG00000111731 E043 79.9001613 0.0029604612 3.727526e-04 1.668443e-03 12 22523426 22523624 199 - 1.788 1.602 -0.629
ENSG00000111731 E044 73.5116889 0.0057083802 1.498197e-04 7.462308e-04 12 22524472 22524627 156 - 1.758 1.522 -0.803
ENSG00000111731 E045 62.1670996 0.0006729647 2.584780e-05 1.561825e-04 12 22525610 22525705 96 - 1.687 1.435 -0.861
ENSG00000111731 E046 78.2278259 0.0004324726 6.220652e-11 1.134357e-09 12 22527721 22527892 172 - 1.798 1.393 -1.383
ENSG00000111731 E047 0.0000000       12 22534707 22535257 551 -      
ENSG00000111731 E048 47.4339471 0.0004695223 2.150022e-05 1.323053e-04 12 22535258 22535344 87 - 1.579 1.274 -1.054
ENSG00000111731 E049 56.2375852 0.0006254709 2.528268e-07 2.376211e-06 12 22544061 22544179 119 - 1.655 1.293 -1.246
ENSG00000111731 E050 6.2272112 0.0052614763 4.804530e-02 1.057135e-01 12 22544180 22544319 140 - 0.778 0.430 -1.564
ENSG00000111731 E051 34.8423761 0.0141253039 1.582303e-03 5.901071e-03 12 22544320 22544546 227 - 1.450 1.137 -1.096