ENSG00000111711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229314 ENSG00000111711 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLT1B protein_coding protein_coding 15.86791 4.262504 25.36771 1.067846 0.4879216 2.570408 12.1508541 3.7260672 18.397182 0.9247504 0.1455161 2.300676 0.78585417 0.87470000 0.72600000 -0.14870000 0.003025915 0.003025915 FALSE FALSE
ENST00000539025 ENSG00000111711 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLT1B protein_coding nonsense_mediated_decay 15.86791 4.262504 25.36771 1.067846 0.4879216 2.570408 0.7603579 0.2029978 1.599980 0.1036551 0.1553086 2.918132 0.05052500 0.04440000 0.06316667 0.01876667 0.720074274 0.003025915   FALSE
ENST00000631252 ENSG00000111711 HEK293_OSMI2_2hA HEK293_TMG_2hB GOLT1B protein_coding protein_coding 15.86791 4.262504 25.36771 1.067846 0.4879216 2.570408 1.7055647 0.1664084 3.465187 0.1664084 0.5900087 4.300100 0.09039583 0.05473333 0.13586667 0.08113333 0.256618850 0.003025915   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111711 E001 0.0000000       12 21501781 21501788 8 +      
ENSG00000111711 E002 0.8448967 0.4278103644 2.220719e-01 3.528902e-01 12 21501789 21501792 4 + 0.144 0.425 2.074
ENSG00000111711 E003 16.0807099 0.0010851620 2.038497e-06 1.582994e-05 12 21501793 21501814 22 + 1.170 0.534 -2.513
ENSG00000111711 E004 16.2279589 0.0010928943 1.731366e-06 1.365537e-05 12 21501815 21501816 2 + 1.174 0.534 -2.527
ENSG00000111711 E005 34.0253339 0.0007236942 1.692183e-03 6.258375e-03 12 21501817 21501823 7 + 1.442 1.272 -0.590
ENSG00000111711 E006 42.1760457 0.0005798774 3.745581e-04 1.675643e-03 12 21501824 21501828 5 + 1.533 1.357 -0.607
ENSG00000111711 E007 42.3275611 0.0005654164 3.393748e-04 1.537902e-03 12 21501829 21501829 1 + 1.535 1.357 -0.612
ENSG00000111711 E008 56.9936368 0.0011139916 7.420136e-05 4.002741e-04 12 21501830 21501852 23 + 1.660 1.489 -0.584
ENSG00000111711 E009 91.0834562 0.0374893702 2.652970e-01 4.033373e-01 12 21501853 21501948 96 + 1.845 1.785 -0.202
ENSG00000111711 E010 84.9003279 0.0110535719 2.948269e-01 4.359308e-01 12 21506885 21506976 92 + 1.806 1.810 0.012
ENSG00000111711 E011 1.4790604 0.0090099639 1.155561e-01 2.136449e-01 12 21506977 21507116 140 + 0.364 0.000 -11.355
ENSG00000111711 E012 1.4768704 0.0544425520 1.320917e-01 2.370182e-01 12 21507117 21507151 35 + 0.364 0.000 -11.355
ENSG00000111711 E013 1.6261957 0.2315080158 1.926164e-01 3.170421e-01 12 21507152 21507305 154 + 0.388 0.000 -11.492
ENSG00000111711 E014 18.4152855 0.0009685936 4.209127e-03 1.372898e-02 12 21507944 21508109 166 + 1.197 0.957 -0.870
ENSG00000111711 E015 127.3871599 0.0002345883 1.622158e-01 2.779906e-01 12 21508383 21508561 179 + 1.975 2.024 0.164
ENSG00000111711 E016 108.1165366 0.0003882338 1.478312e-01 2.587310e-01 12 21512295 21512376 82 + 1.886 2.049 0.550
ENSG00000111711 E017 0.0000000       12 21515238 21515270 33 +      
ENSG00000111711 E018 794.0798768 0.0127968764 1.302741e-03 4.986167e-03 12 21515669 21518408 2740 + 2.737 2.918 0.603