ENSG00000111707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000541591 ENSG00000111707 HEK293_OSMI2_2hA HEK293_TMG_2hB SUDS3 protein_coding processed_transcript 19.64117 14.75044 22.94688 2.746028 1.624514 0.6371913 2.266211 5.353140 0.00000 1.881414 0.0000000 -9.066934 0.1339167 0.3475333 0.0000 -0.3475333 8.190629e-23 8.190629e-23   FALSE
ENST00000543473 ENSG00000111707 HEK293_OSMI2_2hA HEK293_TMG_2hB SUDS3 protein_coding protein_coding 19.64117 14.75044 22.94688 2.746028 1.624514 0.6371913 16.016341 9.076413 21.14903 1.208568 0.8598173 1.219491 0.8019917 0.6321667 0.9255 0.2933333 6.263988e-04 8.190629e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111707 E001 16.718626 0.0011427097 3.402572e-07 3.113376e-06 12 118376555 118376569 15 + 1.332 0.981 -1.258
ENSG00000111707 E002 104.940249 0.0002968666 6.323370e-21 4.515430e-19 12 118376570 118376833 264 + 2.078 1.859 -0.733
ENSG00000111707 E003 85.896188 0.0003253847 1.181057e-11 2.429663e-10 12 118380162 118380231 70 + 1.972 1.833 -0.469
ENSG00000111707 E004 92.012410 0.0011740023 1.034868e-09 1.530943e-08 12 118384012 118384067 56 + 1.997 1.878 -0.401
ENSG00000111707 E005 114.248921 0.0003455254 3.164814e-12 7.161546e-11 12 118386114 118386185 72 + 2.087 1.978 -0.366
ENSG00000111707 E006 77.250697 0.0003530703 2.518696e-07 2.367920e-06 12 118389927 118389946 20 + 1.909 1.827 -0.277
ENSG00000111707 E007 161.093848 0.0024790136 6.531634e-05 3.574540e-04 12 118391126 118391282 157 + 2.203 2.182 -0.070
ENSG00000111707 E008 107.430097 0.0004968135 6.697354e-03 2.043903e-02 12 118400659 118400754 96 + 2.009 2.046 0.126
ENSG00000111707 E009 63.760899 0.0003967384 8.021105e-03 2.383347e-02 12 118401759 118401771 13 + 1.794 1.808 0.047
ENSG00000111707 E010 71.524188 0.0041208784 7.740865e-02 1.553018e-01 12 118401772 118401820 49 + 1.834 1.864 0.104
ENSG00000111707 E011 66.356035 0.0128514156 1.203691e-01 2.205012e-01 12 118401983 118402004 22 + 1.812 1.813 0.004
ENSG00000111707 E012 4.412675 0.0089756973 2.106336e-01 3.392888e-01 12 118402233 118402648 416 + 0.754 0.681 -0.298
ENSG00000111707 E013 111.870874 0.0003136829 1.713468e-06 1.352660e-05 12 118403412 118403500 89 + 2.051 2.020 -0.105
ENSG00000111707 E014 67.513355 0.0003549752 2.812616e-04 1.303525e-03 12 118403501 118403517 17 + 1.834 1.808 -0.088
ENSG00000111707 E015 0.590154 0.0187067384 5.706066e-01 6.970487e-01 12 118404056 118404473 418 + 0.222 0.169 -0.490
ENSG00000111707 E016 103.382139 0.0002717512 2.897666e-05 1.730243e-04 12 118411073 118411157 85 + 2.013 2.000 -0.047
ENSG00000111707 E017 110.991242 0.0002937057 1.198856e-03 4.636514e-03 12 118414335 118414470 136 + 2.030 2.054 0.080
ENSG00000111707 E018 1678.837656 0.0035993695 1.762051e-21 1.332064e-19 12 118414471 118418033 3563 + 3.096 3.358 0.870
ENSG00000111707 E019 0.000000       12 118431823 118431969 147 +