ENSG00000111684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261407 ENSG00000111684 HEK293_OSMI2_2hA HEK293_TMG_2hB LPCAT3 protein_coding protein_coding 29.63095 40.16171 21.92788 2.764119 0.5406761 -0.8727559 26.67196 38.346 19.61188 2.583442 0.184454 -0.9669887 0.8935083 0.955 0.8950667 -0.05993333 0.001020691 0.0001197376 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111684 E001 4.2414936 0.0040482316 2.618810e-02 6.433081e-02 12 6976185 6976185 1 - 0.380 0.762 1.773
ENSG00000111684 E002 556.6313281 0.0036466734 5.567166e-10 8.652743e-09 12 6976186 6976805 620 - 2.544 2.754 0.698
ENSG00000111684 E003 240.4889910 0.0009057115 5.486239e-05 3.060067e-04 12 6976806 6976891 86 - 2.244 2.372 0.428
ENSG00000111684 E004 306.1324086 0.0002021406 1.892595e-01 3.128049e-01 12 6977134 6977262 129 - 2.412 2.452 0.134
ENSG00000111684 E005 345.1153316 0.0014397872 4.070481e-01 5.506691e-01 12 6977367 6977525 159 - 2.466 2.502 0.118
ENSG00000111684 E006 7.2011478 0.0392920782 2.014790e-01 3.280217e-01 12 6977526 6977597 72 - 0.993 0.824 -0.642
ENSG00000111684 E007 167.0202014 0.0038534634 2.363581e-01 3.699434e-01 12 6977598 6977646 49 - 2.131 2.195 0.215
ENSG00000111684 E008 192.5722081 0.0004341722 1.127980e-02 3.182979e-02 12 6977647 6977698 52 - 2.174 2.260 0.288
ENSG00000111684 E009 183.2528076 0.0053477994 4.100147e-01 5.536308e-01 12 6977699 6977745 47 - 2.179 2.233 0.181
ENSG00000111684 E010 10.2635524 0.0017182544 2.570858e-01 3.941260e-01 12 6977746 6977839 94 - 0.902 1.042 0.519
ENSG00000111684 E011 9.1647828 0.0022853814 6.549079e-01 7.649426e-01 12 6977840 6978040 201 - 0.993 0.952 -0.153
ENSG00000111684 E012 12.0934616 0.0149679620 6.920539e-01 7.933554e-01 12 6978041 6978340 300 - 1.102 1.067 -0.125
ENSG00000111684 E013 204.1759672 0.0002291460 9.361637e-01 9.638353e-01 12 6978341 6978420 80 - 2.254 2.267 0.044
ENSG00000111684 E014 214.1392769 0.0002723074 4.720583e-01 6.111264e-01 12 6978421 6978507 87 - 2.292 2.284 -0.026
ENSG00000111684 E015 222.9717842 0.0002842943 1.020435e-01 1.936285e-01 12 6978603 6978689 87 - 2.325 2.294 -0.104
ENSG00000111684 E016 6.3867571 0.0239483645 2.077491e-02 5.311254e-02 12 6978690 6979270 581 - 1.033 0.724 -1.186
ENSG00000111684 E017 249.1492110 0.0002507499 4.095461e-02 9.279554e-02 12 6979471 6979579 109 - 2.378 2.340 -0.128
ENSG00000111684 E018 2.2465387 0.0592795820 1.275676e-04 6.480907e-04 12 6979595 6979967 373 - 0.848 0.162 -3.738
ENSG00000111684 E019 2.1454698 0.1833755007 2.900671e-01 4.308467e-01 12 6980707 6981003 297 - 0.579 0.384 -0.975
ENSG00000111684 E020 286.8619499 0.0014288417 1.962538e-01 3.215371e-01 12 6981004 6981182 179 - 2.427 2.405 -0.073
ENSG00000111684 E021 1.5082172 0.0087981260 2.175011e-03 7.765009e-03 12 6981294 6981541 248 - 0.674 0.163 -3.035
ENSG00000111684 E022 0.5891098 0.0184018678 5.314680e-03 1.678923e-02 12 6981542 6981559 18 - 0.457 0.000 -13.324
ENSG00000111684 E023 0.7750806 0.0246850947 3.120493e-02 7.429815e-02 12 6981560 6981594 35 - 0.457 0.089 -3.034
ENSG00000111684 E024 159.5571036 0.0022802314 1.956440e-01 3.207685e-01 12 6981595 6981632 38 - 2.182 2.147 -0.114
ENSG00000111684 E025 0.8105550 0.0139082473 2.994075e-02 7.184165e-02 12 6981633 6981808 176 - 0.457 0.089 -3.033
ENSG00000111684 E026 1.1050505 0.0836609398 9.564045e-01 9.766966e-01 12 6981809 6981810 2 - 0.286 0.283 -0.016
ENSG00000111684 E027 230.1469189 0.0011510084 4.631520e-04 2.018746e-03 12 6981811 6981904 94 - 2.378 2.290 -0.291
ENSG00000111684 E028 243.6308894 0.0002165637 2.769524e-09 3.785010e-08 12 6982676 6982782 107 - 2.430 2.300 -0.435
ENSG00000111684 E029 0.1472490 0.0428402741 2.341755e-01   12 6982783 6982783 1 - 0.166 0.000 -11.324
ENSG00000111684 E030 204.7248026 0.0016524093 4.417683e-05 2.522086e-04 12 6983432 6983539 108 - 2.346 2.230 -0.386
ENSG00000111684 E031 0.4460135 0.0266959408 1.860125e-02 4.845717e-02 12 7001428 7001486 59 - 0.380 0.000 -12.909
ENSG00000111684 E032 139.5921132 0.0063495960 4.906516e-04 2.124774e-03 12 7018274 7018477 204 - 2.209 2.054 -0.519