ENSG00000111678

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229281 ENSG00000111678 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf57 protein_coding protein_coding 248.6071 486.2109 151.0945 22.525 4.020014 -1.686065 199.82264 401.41174 107.44974 19.426488 2.4008335 -1.9013225 0.78187083 0.82560000 0.7113000 -0.1143000 1.337380e-07 3.124197e-13 FALSE TRUE
ENST00000458811 ENSG00000111678 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf57 protein_coding snRNA 248.6071 486.2109 151.0945 22.525 4.020014 -1.686065 18.80657 24.73116 24.21230 2.898955 1.8931779 -0.0305777 0.09834167 0.05066667 0.1598333 0.1091667 3.124197e-13 3.124197e-13   FALSE
ENST00000537087 ENSG00000111678 HEK293_OSMI2_2hA HEK293_TMG_2hB C12orf57 protein_coding protein_coding 248.6071 486.2109 151.0945 22.525 4.020014 -1.686065 25.10478 52.87055 15.49255 3.065427 0.3490955 -1.7702320 0.09603333 0.10886667 0.1027667 -0.0061000 8.249738e-01 3.124197e-13   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111678 E001 6.601241 2.657060e-02 7.261107e-04 2.992831e-03 12 6942978 6943244 267 + 1.118 0.636 -1.864
ENSG00000111678 E002 6.754723 1.614600e-02 6.579731e-08 6.925826e-07 12 6943433 6943501 69 + 1.251 0.548 -2.733
ENSG00000111678 E003 5.078152 1.348262e-02 7.186384e-05 3.892717e-04 12 6943502 6943541 40 + 1.071 0.507 -2.282
ENSG00000111678 E004 10.142412 1.040913e-02 4.295558e-07 3.849664e-06 12 6943542 6943662 121 + 1.339 0.770 -2.094
ENSG00000111678 E005 2.910985 1.699844e-02 2.633793e-03 9.171797e-03 12 6943816 6943816 1 + 0.849 0.355 -2.260
ENSG00000111678 E006 24.717960 8.347816e-04 7.999307e-08 8.278672e-07 12 6943817 6943833 17 + 1.588 1.181 -1.411
ENSG00000111678 E007 190.170999 1.717898e-03 2.672549e-09 3.662783e-08 12 6943834 6944021 188 + 2.317 2.105 -0.711
ENSG00000111678 E008 1369.522780 7.901539e-05 8.744422e-01 9.232864e-01 12 6944022 6944106 85 + 3.003 3.001 -0.007
ENSG00000111678 E009 1448.329824 7.482850e-05 1.339258e-03 5.107363e-03 12 6944107 6944121 15 + 2.993 3.032 0.129
ENSG00000111678 E010 1648.499844 6.374148e-05 1.275056e-01 2.306768e-01 12 6944122 6944173 52 + 3.068 3.085 0.056
ENSG00000111678 E011 40.242798 1.578551e-03 9.512189e-05 4.991153e-04 12 6944380 6944475 96 + 1.688 1.433 -0.871
ENSG00000111678 E012 2074.798633 7.138832e-05 7.791302e-01 8.579675e-01 12 6944476 6944565 90 + 3.184 3.181 -0.009
ENSG00000111678 E013 1655.328914 4.053204e-04 6.261895e-01 7.421779e-01 12 6944566 6944652 87 + 3.078 3.086 0.028
ENSG00000111678 E014 21.755660 4.609210e-03 5.236618e-03 1.657552e-02 12 6944653 6945098 446 + 1.424 1.177 -0.867
ENSG00000111678 E015 1615.445100 6.848904e-04 2.891430e-01 4.298212e-01 12 6945771 6946003 233 + 3.060 3.078 0.060