ENSG00000111676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356654 ENSG00000111676 HEK293_OSMI2_2hA HEK293_TMG_2hB ATN1 protein_coding protein_coding 33.90417 45.49698 26.79266 4.63838 0.6847085 -0.7637115 19.371941 26.325110 13.885223 1.623339 0.9189619 -0.9223985 0.5843750 0.5853333 0.5188667 -0.06646667 6.076812e-01 2.483206e-42 FALSE TRUE
ENST00000396684 ENSG00000111676 HEK293_OSMI2_2hA HEK293_TMG_2hB ATN1 protein_coding protein_coding 33.90417 45.49698 26.79266 4.63838 0.6847085 -0.7637115 4.913935 5.827256 4.002340 1.855303 0.6498003 -0.5408463 0.1336750 0.1256667 0.1499000 0.02423333 8.004744e-01 2.483206e-42 FALSE TRUE
ENST00000541029 ENSG00000111676 HEK293_OSMI2_2hA HEK293_TMG_2hB ATN1 protein_coding retained_intron 33.90417 45.49698 26.79266 4.63838 0.6847085 -0.7637115 4.451055 8.639879 3.085158 1.711596 0.7046865 -1.4826668 0.1137833 0.1860667 0.1141667 -0.07190000 2.613312e-01 2.483206e-42 FALSE FALSE
MSTRG.6722.7 ENSG00000111676 HEK293_OSMI2_2hA HEK293_TMG_2hB ATN1 protein_coding   33.90417 45.49698 26.79266 4.63838 0.6847085 -0.7637115 2.951731 0.000000 4.429145 0.000000 0.5071332 8.7941380 0.1097583 0.0000000 0.1648667 0.16486667 2.483206e-42 2.483206e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111676 E001 0.147249 0.0428370701 2.702086e-01   12 6924463 6924537 75 + 0.159 0.000 -9.304
ENSG00000111676 E002 4.552771 0.0537999544 2.560936e-01 3.930471e-01 12 6927925 6927958 34 + 0.830 0.642 -0.767
ENSG00000111676 E003 1.656612 0.0088773633 1.345855e-04 6.793974e-04 12 6927959 6927964 6 + 0.735 0.093 -4.213
ENSG00000111676 E004 3.114568 0.0907425480 3.657667e-06 2.686365e-05 12 6927965 6928052 88 + 0.993 0.093 -5.207
ENSG00000111676 E005 5.896314 0.0141837001 1.646445e-05 1.041090e-04 12 6928053 6928249 197 + 1.113 0.531 -2.320
ENSG00000111676 E006 5.612319 0.0872255049 1.990049e-01 3.249712e-01 12 6928250 6928252 3 + 0.932 0.692 -0.946
ENSG00000111676 E007 83.694420 0.0151735835 2.170425e-02 5.506120e-02 12 6928253 6928384 132 + 1.990 1.836 -0.515
ENSG00000111676 E008 69.439488 0.0146457310 2.846352e-02 6.894151e-02 12 6933840 6933855 16 + 1.907 1.757 -0.506
ENSG00000111676 E009 77.879425 0.0091376928 7.807207e-05 4.188644e-04 12 6933856 6933867 12 + 2.009 1.770 -0.803
ENSG00000111676 E010 254.111845 0.0059613281 1.544309e-06 1.230660e-05 12 6933868 6934028 161 + 2.497 2.297 -0.667
ENSG00000111676 E011 313.198725 0.0012247236 2.666512e-11 5.179031e-10 12 6934176 6934313 138 + 2.569 2.397 -0.573
ENSG00000111676 E012 289.248300 0.0032610819 2.311870e-05 1.412555e-04 12 6934465 6934578 114 + 2.520 2.377 -0.477
ENSG00000111676 E013 102.246417 0.0126362726 1.440524e-01 2.535283e-01 12 6935547 6935549 3 + 2.038 1.949 -0.299
ENSG00000111676 E014 1627.613640 0.0014320490 1.896710e-04 9.198392e-04 12 6935550 6937561 2012 + 3.213 3.158 -0.184
ENSG00000111676 E015 9.826128 0.0018400562 1.402963e-01 2.484271e-01 12 6937698 6937844 147 + 1.098 0.937 -0.591
ENSG00000111676 E016 265.867358 0.0015165905 1.210208e-01 2.213931e-01 12 6937845 6938067 223 + 2.354 2.399 0.152
ENSG00000111676 E017 105.228654 0.0002798122 2.822121e-01 4.221849e-01 12 6938481 6938483 3 + 1.959 1.995 0.120
ENSG00000111676 E018 917.548881 0.0016156760 2.910282e-04 1.343300e-03 12 6938484 6939106 623 + 2.872 2.948 0.253
ENSG00000111676 E019 278.522597 0.0081124314 2.331216e-02 5.839970e-02 12 6939107 6939177 71 + 2.331 2.443 0.370
ENSG00000111676 E020 424.151540 0.0036336899 3.584462e-05 2.090011e-04 12 6940880 6941023 144 + 2.492 2.631 0.464
ENSG00000111676 E021 442.145949 0.0009386172 1.072601e-10 1.883410e-09 12 6941374 6941554 181 + 2.501 2.648 0.490
ENSG00000111676 E022 3.921993 0.0533297767 2.243144e-01 3.555865e-01 12 6941555 6941746 192 + 0.508 0.723 0.948
ENSG00000111676 E023 435.994066 0.0049198624 2.552847e-10 4.195986e-09 12 6941747 6942321 575 + 2.425 2.666 0.801