ENSG00000111674

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229277 ENSG00000111674 HEK293_OSMI2_2hA HEK293_TMG_2hB ENO2 protein_coding protein_coding 13.30653 23.18784 7.142349 0.4982915 0.1333776 -1.697501 9.3142590 18.2631580 4.6490723 0.92896654 0.22193251 -1.9716114 0.67394167 0.78666667 0.65030000 -0.13636667 0.021749591 0.001769707 FALSE TRUE
ENST00000535366 ENSG00000111674 HEK293_OSMI2_2hA HEK293_TMG_2hB ENO2 protein_coding protein_coding 13.30653 23.18784 7.142349 0.4982915 0.1333776 -1.697501 0.5828616 0.4846008 0.3751961 0.08668098 0.03746813 -0.3606715 0.05068333 0.02086667 0.05273333 0.03186667 0.020792553 0.001769707 FALSE TRUE
ENST00000537688 ENSG00000111674 HEK293_OSMI2_2hA HEK293_TMG_2hB ENO2 protein_coding protein_coding 13.30653 23.18784 7.142349 0.4982915 0.1333776 -1.697501 0.7752910 1.3739295 0.5071273 0.40454465 0.19755502 -1.4201791 0.06338333 0.05946667 0.07033333 0.01086667 0.944139781 0.001769707 FALSE FALSE
ENST00000542509 ENSG00000111674 HEK293_OSMI2_2hA HEK293_TMG_2hB ENO2 protein_coding retained_intron 13.30653 23.18784 7.142349 0.4982915 0.1333776 -1.697501 0.8020778 0.5207107 0.7518289 0.16767873 0.13348403 0.5215413 0.07923750 0.02230000 0.10533333 0.08303333 0.001769707 0.001769707   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111674 E001 0.3299976 0.0278132939 1.000000e+00   12 6913745 6913842 98 + 0.000 0.126 8.391
ENSG00000111674 E002 1.6878282 0.0672100252 9.166330e-01 9.513168e-01 12 6914327 6914532 206 + 0.354 0.342 -0.071
ENSG00000111674 E003 1.8361213 0.0144974131 9.653006e-01 9.821707e-01 12 6914533 6914537 5 + 0.354 0.371 0.102
ENSG00000111674 E004 4.3438660 0.0110701767 9.731481e-01 9.872391e-01 12 6914538 6914556 19 + 0.618 0.624 0.030
ENSG00000111674 E005 8.7416201 0.0022271980 9.265947e-01 9.577789e-01 12 6914557 6914579 23 + 0.863 0.889 0.099
ENSG00000111674 E006 10.5754773 0.0034388909 8.701827e-01 9.204962e-01 12 6914580 6914588 9 + 0.932 0.966 0.129
ENSG00000111674 E007 11.9342528 0.0029700219 8.085832e-01 8.784122e-01 12 6914589 6914593 5 + 1.018 1.004 -0.053
ENSG00000111674 E008 17.4334503 0.0010637449 3.492822e-02 8.151682e-02 12 6914594 6914596 3 + 1.298 1.118 -0.638
ENSG00000111674 E009 25.2406986 0.0008062192 6.801890e-02 1.400790e-01 12 6914597 6914609 13 + 1.407 1.275 -0.458
ENSG00000111674 E010 38.7397279 0.0007254158 2.810093e-01 4.208742e-01 12 6914610 6914659 50 + 1.528 1.470 -0.200
ENSG00000111674 E011 5.2820954 0.0030119405 2.212342e-06 1.704335e-05 12 6915207 6915435 229 + 1.112 0.504 -2.448
ENSG00000111674 E012 4.9682890 0.0282370996 2.593418e-01 3.967147e-01 12 6915436 6915817 382 + 0.823 0.655 -0.686
ENSG00000111674 E013 4.7877276 0.0035258441 8.310487e-01 8.940763e-01 12 6915818 6915820 3 + 0.679 0.657 -0.093
ENSG00000111674 E014 65.4108300 0.0012817434 1.453472e-01 2.553292e-01 12 6915821 6915917 97 + 1.756 1.692 -0.214
ENSG00000111674 E015 83.7031396 0.0003428160 1.680975e-01 2.857181e-01 12 6916417 6916512 96 + 1.850 1.802 -0.164
ENSG00000111674 E016 0.3030308 0.3462746428 4.742990e-02   12 6916513 6916670 158 + 0.355 0.000 -12.579
ENSG00000111674 E017 77.6955584 0.0003561161 1.988665e-01 3.247899e-01 12 6916671 6916729 59 + 1.818 1.772 -0.157
ENSG00000111674 E018 9.3866652 0.0033879692 1.787102e-09 2.527330e-08 12 6916730 6917037 308 + 1.338 0.703 -2.359
ENSG00000111674 E019 91.5414029 0.0004133206 2.083179e-02 5.323638e-02 12 6917038 6917107 70 + 1.918 1.832 -0.290
ENSG00000111674 E020 1.5531523 0.0117743717 3.756297e-01 5.200412e-01 12 6917108 6917259 152 + 0.460 0.303 -0.901
ENSG00000111674 E021 1.4854006 0.0101232017 3.168976e-03 1.076397e-02 12 6917329 6917580 252 + 0.679 0.178 -2.901
ENSG00000111674 E022 118.3264191 0.0003344605 8.287060e-01 8.923769e-01 12 6917581 6917714 134 + 1.953 1.960 0.023
ENSG00000111674 E023 166.4189636 0.0002310207 4.018781e-01 5.455761e-01 12 6917940 6918162 223 + 2.116 2.104 -0.040
ENSG00000111674 E024 58.9598449 0.0004457769 8.563820e-01 9.111945e-01 12 6919566 6919573 8 + 1.641 1.667 0.088
ENSG00000111674 E025 142.4335226 0.0002506349 5.162529e-01 6.508369e-01 12 6919574 6919763 190 + 2.046 2.038 -0.026
ENSG00000111674 E026 1.5511777 0.0118704493 2.320281e-02 5.816806e-02 12 6921497 6921580 84 + 0.618 0.224 -2.221
ENSG00000111674 E027 156.0499544 0.0028163599 5.768266e-01 7.021974e-01 12 6921581 6921782 202 + 2.084 2.078 -0.018
ENSG00000111674 E028 2.4345952 0.0062175697 2.518498e-02 6.225173e-02 12 6921989 6922055 67 + 0.733 0.370 -1.710
ENSG00000111674 E029 81.1890894 0.0006680662 8.886844e-01 9.328217e-01 12 6922056 6922092 37 + 1.793 1.802 0.030
ENSG00000111674 E030 82.3010515 0.0003708025 6.391492e-02 1.332123e-01 12 6922093 6922164 72 + 1.716 1.825 0.370
ENSG00000111674 E031 76.4971379 0.0003592753 7.691387e-01 8.508424e-01 12 6922344 6922402 59 + 1.751 1.781 0.103
ENSG00000111674 E032 402.7763618 0.0030571346 3.655262e-09 4.880046e-08 12 6922731 6923698 968 + 2.321 2.523 0.677