ENSG00000111670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000299314 ENSG00000111670 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPTAB protein_coding protein_coding 8.860265 3.3981 12.74844 0.07461449 0.1253469 1.904412 7.2658406 2.1900195 10.8010931 0.09508213 0.35283043 2.2969242 0.7726333 0.6449667 0.84730000 0.2023333 3.405183e-03 3.548282e-05 FALSE TRUE
ENST00000392919 ENSG00000111670 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPTAB protein_coding protein_coding 8.860265 3.3981 12.74844 0.07461449 0.1253469 1.904412 0.1764762 0.4749346 0.2091473 0.05642146 0.07837323 -1.1458893 0.0371875 0.1405667 0.01643333 -0.1241333 3.548282e-05 3.548282e-05   FALSE
ENST00000552009 ENSG00000111670 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPTAB protein_coding retained_intron 8.860265 3.3981 12.74844 0.07461449 0.1253469 1.904412 0.7272284 0.5837327 0.8933172 0.11784789 0.10687205 0.6054192 0.1057792 0.1706333 0.07016667 -0.1004667 1.240362e-02 3.548282e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111670 E001 2.5934855 0.0573611642 3.228288e-02 7.639856e-02 12 101745387 101745498 112 - 0.360 0.791 2.003
ENSG00000111670 E002 299.4265503 0.0050830967 3.221197e-22 2.623586e-20 12 101745499 101747241 1743 - 2.270 2.653 1.275
ENSG00000111670 E003 32.0754107 0.0016791383 3.653484e-01 5.096621e-01 12 101749101 101749141 41 - 1.394 1.516 0.418
ENSG00000111670 E004 41.2517415 0.0005716322 8.255949e-01 8.901956e-01 12 101749142 101749191 50 - 1.514 1.553 0.135
ENSG00000111670 E005 63.8323428 0.0003972718 1.134838e-01 2.106088e-01 12 101753372 101753539 168 - 1.712 1.678 -0.118
ENSG00000111670 E006 0.6224193 0.0180519132 1.496678e-01 2.612247e-01 12 101756215 101756419 205 - 0.109 0.394 2.367
ENSG00000111670 E007 0.5901540 0.0199344556 7.190009e-01 8.139698e-01 12 101756420 101756566 147 - 0.155 0.240 0.781
ENSG00000111670 E008 0.2214452 0.0389209487 8.971587e-02   12 101756942 101757211 270 - 0.000 0.241 11.166
ENSG00000111670 E009 46.4930904 0.0004666617 1.152045e-02 3.239547e-02 12 101757212 101757310 99 - 1.594 1.475 -0.407
ENSG00000111670 E010 47.5937910 0.0004837442 6.450951e-03 1.979580e-02 12 101757572 101757657 86 - 1.606 1.475 -0.450
ENSG00000111670 E011 55.4617461 0.0005782636 5.843824e-01 7.083322e-01 12 101760030 101760143 114 - 1.642 1.664 0.075
ENSG00000111670 E012 0.0000000       12 101760144 101760144 1 -      
ENSG00000111670 E013 70.3769243 0.0060522300 4.894679e-01 6.268979e-01 12 101761127 101761346 220 - 1.744 1.755 0.036
ENSG00000111670 E014 54.4944694 0.0004867229 1.550383e-01 2.684644e-01 12 101761564 101761763 200 - 1.645 1.612 -0.110
ENSG00000111670 E015 197.7596478 0.0002789344 2.475494e-13 6.658739e-12 12 101764202 101765304 1103 - 2.224 2.028 -0.654
ENSG00000111670 E016 5.8063705 0.0030158831 1.151728e-03 4.477098e-03 12 101765761 101766090 330 - 0.603 1.082 1.882
ENSG00000111670 E017 67.8416744 0.0005194961 2.820013e-01 4.219662e-01 12 101766091 101766294 204 - 1.732 1.729 -0.013
ENSG00000111670 E018 0.1472490 0.0426719361 1.000000e+00   12 101767910 101768036 127 - 0.058 0.000 -8.847
ENSG00000111670 E019 52.5579008 0.0004447785 6.780377e-01 7.825962e-01 12 101768037 101768160 124 - 1.620 1.650 0.101
ENSG00000111670 E020 67.0812367 0.0004015374 7.037032e-04 2.912322e-03 12 101770021 101770191 171 - 1.754 1.612 -0.481
ENSG00000111670 E021 62.4757890 0.0004223755 4.427771e-03 1.433845e-02 12 101770406 101770585 180 - 1.718 1.604 -0.388
ENSG00000111670 E022 50.7382630 0.0006929699 2.293563e-04 1.089322e-03 12 101770996 101771157 162 - 1.642 1.441 -0.686
ENSG00000111670 E023 2.8074341 0.1887037960 8.174914e-01 8.846047e-01 12 101778290 101780151 1862 - 0.517 0.499 -0.086
ENSG00000111670 E024 42.9056406 0.0006801632 2.013486e-05 1.247747e-04 12 101780152 101780286 135 - 1.583 1.306 -0.954
ENSG00000111670 E025 30.7625719 0.0006618118 2.134038e-01 3.425407e-01 12 101780557 101780621 65 - 1.411 1.365 -0.160
ENSG00000111670 E026 0.5159433 0.2219085519 5.094416e-01 6.447815e-01 12 101785590 101786011 422 - 0.109 0.243 1.391
ENSG00000111670 E027 56.6821431 0.0004384611 8.069603e-01 8.773786e-01 12 101786012 101786217 206 - 1.650 1.691 0.138
ENSG00000111670 E028 37.9046965 0.0156709228 7.254461e-01 8.187150e-01 12 101788548 101788589 42 - 1.480 1.500 0.070
ENSG00000111670 E029 59.6979614 0.0083727611 2.404884e-01 3.747250e-01 12 101789938 101790057 120 - 1.684 1.651 -0.112
ENSG00000111670 E030 0.0000000       12 101795871 101795873 3 -      
ENSG00000111670 E031 6.2644195 0.0029099920 5.851821e-13 1.490468e-11 12 101795874 101796262 389 - 0.386 1.321 3.801
ENSG00000111670 E032 0.0000000       12 101796511 101796676 166 -      
ENSG00000111670 E033 49.6698001 0.0025059245 6.157434e-01 7.339386e-01 12 101796677 101796762 86 - 1.598 1.620 0.073
ENSG00000111670 E034 0.4460135 0.0293813047 7.081140e-01 8.058271e-01 12 101810527 101810658 132 - 0.155 0.000 -10.515
ENSG00000111670 E035 42.6773199 0.0033679712 1.908697e-01 3.148372e-01 12 101830559 101830959 401 - 1.547 1.506 -0.142