ENSG00000111666

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229266 ENSG00000111666 HEK293_OSMI2_2hA HEK293_TMG_2hB CHPT1 protein_coding protein_coding 46.22594 38.76803 54.03303 6.164593 1.815417 0.4788691 18.88385 20.57700 18.75066 2.868347 0.9909182 -0.1340231 0.4202583 0.5340667 0.3486333 -0.1854333 0.001559149 0.000662327 FALSE TRUE
MSTRG.7870.3 ENSG00000111666 HEK293_OSMI2_2hA HEK293_TMG_2hB CHPT1 protein_coding   46.22594 38.76803 54.03303 6.164593 1.815417 0.4788691 23.12375 14.70516 31.57804 3.530466 2.1745747 1.1020746 0.4883708 0.3708333 0.5835000 0.2126667 0.000662327 0.000662327 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111666 E001 0.0000000       12 101696947 101697028 82 +      
ENSG00000111666 E002 28.2167482 0.0413253050 8.057400e-04 3.279061e-03 12 101697640 101697671 32 + 1.646 1.221 -1.469
ENSG00000111666 E003 43.2021582 0.0260048807 4.028557e-06 2.927944e-05 12 101697672 101697691 20 + 1.841 1.369 -1.610
ENSG00000111666 E004 96.0252541 0.0132695915 4.648570e-17 2.082425e-15 12 101697692 101697853 162 + 2.219 1.602 -2.078
ENSG00000111666 E005 112.7528893 0.0081788806 3.285987e-14 1.001917e-12 12 101697854 101697964 111 + 2.247 1.786 -1.545
ENSG00000111666 E006 332.2606809 0.0035479583 1.206034e-07 1.206397e-06 12 101697965 101698134 170 + 2.623 2.422 -0.669
ENSG00000111666 E007 530.0291461 0.0009536679 6.752472e-08 7.089142e-07 12 101714090 101714237 148 + 2.793 2.668 -0.417
ENSG00000111666 E008 0.1451727 0.0443133224 5.253003e-01   12 101714238 101714284 47 + 0.122 0.000 -11.090
ENSG00000111666 E009 337.9709234 0.0003919193 4.154370e-03 1.357609e-02 12 101714504 101714527 24 + 2.575 2.503 -0.241
ENSG00000111666 E010 598.5742158 0.0004603438 8.557148e-02 1.683243e-01 12 101714528 101714645 118 + 2.807 2.764 -0.143
ENSG00000111666 E011 2.8379483 0.0692370469 3.858614e-01 5.300579e-01 12 101714884 101715076 193 + 0.661 0.475 -0.850
ENSG00000111666 E012 495.6161690 0.0006377489 6.424691e-01 7.552408e-01 12 101716728 101716812 85 + 2.706 2.700 -0.018
ENSG00000111666 E013 0.5954526 0.0183386109 4.217824e-02 9.505191e-02 12 101717237 101717394 158 + 0.362 0.000 -13.091
ENSG00000111666 E014 0.4427912 0.1807229285 6.242697e-01 7.406485e-01 12 101719490 101719516 27 + 0.217 0.121 -1.012
ENSG00000111666 E015 469.9635333 0.0001355780 1.835960e-04 8.932358e-04 12 101720123 101720254 132 + 2.654 2.701 0.157
ENSG00000111666 E016 644.4908535 0.0001397571 8.454024e-04 3.421249e-03 12 101723168 101723326 159 + 2.798 2.831 0.107
ENSG00000111666 E017 592.6085158 0.0003573601 7.111344e-05 3.855597e-04 12 101723722 101723847 126 + 2.752 2.799 0.157
ENSG00000111666 E018 323.2092515 0.0009625013 5.142468e-07 4.537823e-06 12 101726294 101726322 29 + 2.456 2.558 0.340
ENSG00000111666 E019 426.8024332 0.0002721512 2.677510e-19 1.579714e-17 12 101726323 101726404 82 + 2.550 2.698 0.492
ENSG00000111666 E020 38.5582239 0.0061587129 8.360173e-01 8.974596e-01 12 101726405 101726501 97 + 1.603 1.594 -0.028
ENSG00000111666 E021 6.2156764 0.0034623060 3.974206e-01 5.411769e-01 12 101726502 101726517 16 + 0.928 0.815 -0.436
ENSG00000111666 E022 34.9163618 0.0006569522 2.197586e-06 1.693760e-05 12 101726518 101728900 2383 + 1.694 1.399 -1.008
ENSG00000111666 E023 209.7838002 0.0028996484 5.043523e-08 5.434733e-07 12 101728901 101728907 7 + 2.225 2.396 0.570
ENSG00000111666 E024 279.4726433 0.0014951533 1.112633e-11 2.300142e-10 12 101728908 101729646 739 + 2.351 2.521 0.567
ENSG00000111666 E025 2.9076771 0.0056875807 6.946530e-01 7.954349e-01 12 101730521 101730636 116 + 0.629 0.557 -0.320
ENSG00000111666 E026 0.1472490 0.0453330667 5.247394e-01   12 101739578 101739769 192 + 0.122 0.000 -11.090
ENSG00000111666 E027 1.8391332 0.2502104810 3.042446e-01 4.462566e-01 12 101742397 101742506 110 + 0.594 0.295 -1.591
ENSG00000111666 E028 0.9179495 0.8427246268 6.053432e-01 7.257577e-01 12 101742507 101742509 3 + 0.419 0.123 -2.305
ENSG00000111666 E029 5.1337255 0.0039929328 7.826202e-01 8.604416e-01 12 101743715 101744029 315 + 0.769 0.793 0.096
ENSG00000111666 E030 1.8175908 0.0079070374 2.003262e-02 5.155851e-02 12 101744030 101744140 111 + 0.629 0.218 -2.320
ENSG00000111666 E031 2.5831039 0.0348686955 7.196569e-01 8.144200e-01 12 101748550 101748615 66 + 0.594 0.516 -0.361