ENSG00000111665

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000535406 ENSG00000111665 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA3 protein_coding protein_coding 103.954 162.5438 66.78366 4.339395 0.9080052 -1.283134 5.931317 8.203359 5.786415 0.1593406 0.204832 -0.5028114 0.06061250 0.05060000 0.08663333 0.03603333 5.459025e-06 2.820646e-17 FALSE  
ENST00000536241 ENSG00000111665 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA3 protein_coding retained_intron 103.954 162.5438 66.78366 4.339395 0.9080052 -1.283134 4.642124 3.427056 5.334574 0.1706631 0.324276 0.6369019 0.05372083 0.02116667 0.07983333 0.05866667 2.820646e-17 2.820646e-17 TRUE  
ENST00000538862 ENSG00000111665 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA3 protein_coding protein_coding 103.954 162.5438 66.78366 4.339395 0.9080052 -1.283134 45.578105 65.331120 21.610635 0.4433981 1.984159 -1.5955823 0.43360833 0.40246667 0.32340000 -0.07906667 2.039873e-01 2.820646e-17 FALSE  
ENST00000540683 ENSG00000111665 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA3 protein_coding protein_coding 103.954 162.5438 66.78366 4.339395 0.9080052 -1.283134 27.168006 53.152377 17.772642 2.6021825 1.860832 -1.5799360 0.24858333 0.32663333 0.26636667 -0.06026667 3.596293e-01 2.820646e-17 FALSE  
ENST00000545368 ENSG00000111665 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA3 protein_coding processed_transcript 103.954 162.5438 66.78366 4.339395 0.9080052 -1.283134 3.729930 3.459998 5.068940 2.1214108 2.830209 0.5495927 0.04154583 0.02160000 0.07556667 0.05396667 8.549032e-01 2.820646e-17 FALSE  
MSTRG.6716.11 ENSG00000111665 HEK293_OSMI2_2hA HEK293_TMG_2hB CDCA3 protein_coding   103.954 162.5438 66.78366 4.339395 0.9080052 -1.283134 6.408466 13.501467 4.547591 1.8336842 2.697518 -1.5678411 0.05873750 0.08270000 0.06843333 -0.01426667 8.191866e-01 2.820646e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111665 E001 1.106097 0.0115872730 1.524571e-02 4.104265e-02 12 6844793 6844798 6 - 0.568 0.144 -2.782
ENSG00000111665 E002 8.150098 0.0527851317 2.351924e-01 3.685858e-01 12 6844799 6844858 60 - 1.008 0.835 -0.650
ENSG00000111665 E003 202.751542 0.0030827831 8.390378e-09 1.048711e-07 12 6844859 6846367 1509 - 2.387 2.172 -0.720
ENSG00000111665 E004 11.503289 0.0357973005 9.026098e-03 2.634326e-02 12 6846368 6846724 357 - 1.262 0.920 -1.237
ENSG00000111665 E005 36.511191 0.0007353862 7.986043e-07 6.771694e-06 12 6846725 6846903 179 - 1.709 1.407 -1.033
ENSG00000111665 E006 53.298600 0.0197507853 6.451211e-08 6.799614e-07 12 6848061 6848815 755 - 1.952 1.505 -1.516
ENSG00000111665 E007 6.033610 0.0028682776 8.824720e-01 9.287561e-01 12 6848816 6848827 12 - 0.768 0.785 0.071
ENSG00000111665 E008 6.406382 0.0026512161 4.182176e-01 5.615052e-01 12 6848828 6848828 1 - 0.726 0.838 0.446
ENSG00000111665 E009 6.849173 0.0025650391 7.296176e-01 8.217682e-01 12 6848829 6848831 3 - 0.806 0.850 0.171
ENSG00000111665 E010 12.139970 0.0018774563 3.797084e-01 5.239611e-01 12 6848832 6848842 11 - 0.984 1.078 0.346
ENSG00000111665 E011 721.755141 0.0006801598 2.770304e-06 2.089607e-05 12 6848843 6849074 232 - 2.717 2.803 0.289
ENSG00000111665 E012 817.460850 0.0003715070 2.924724e-02 7.048381e-02 12 6849075 6849153 79 - 2.813 2.846 0.108
ENSG00000111665 E013 690.445710 0.0005283048 3.728214e-02 8.600292e-02 12 6849154 6849198 45 - 2.737 2.773 0.118
ENSG00000111665 E014 609.641060 0.0003040824 4.188132e-01 5.620672e-01 12 6849323 6849413 91 - 2.703 2.714 0.038
ENSG00000111665 E015 323.135980 0.0001891768 3.423342e-01 4.863310e-01 12 6849414 6849429 16 - 2.421 2.439 0.062
ENSG00000111665 E016 49.166906 0.0006430331 7.078217e-21 5.037366e-19 12 6849430 6849550 121 - 1.941 1.460 -1.632
ENSG00000111665 E017 31.203889 0.0098148691 1.670873e-07 1.626294e-06 12 6849551 6849564 14 - 1.714 1.301 -1.417
ENSG00000111665 E018 1153.905612 0.0001010064 3.426837e-03 1.151561e-02 12 6849565 6849783 219 - 2.963 2.995 0.105
ENSG00000111665 E019 600.573671 0.0001540441 9.341416e-01 9.625014e-01 12 6849784 6849858 75 - 2.705 2.703 -0.007
ENSG00000111665 E020 16.123696 0.0011314771 4.236908e-10 6.723652e-09 12 6850199 6850466 268 - 1.502 0.975 -1.867
ENSG00000111665 E021 829.000259 0.0007040771 3.119108e-01 4.544309e-01 12 6850467 6850596 130 - 2.832 2.847 0.049
ENSG00000111665 E022 53.349301 0.0118518628 8.960425e-14 2.564625e-12 12 6850597 6850832 236 - 2.004 1.476 -1.789
ENSG00000111665 E023 785.528516 0.0001403852 1.076631e-01 2.020871e-01 12 6850833 6851009 177 - 2.804 2.824 0.068
ENSG00000111665 E024 78.863983 0.0003570185 6.844919e-08 7.177050e-07 12 6851010 6851221 212 - 1.997 1.765 -0.779
ENSG00000111665 E025 485.114671 0.0001628709 4.517124e-01 5.926408e-01 12 6851222 6851292 71 - 2.601 2.612 0.036