ENSG00000111652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229251 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding protein_coding 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 4.878584 9.684374 3.9986554 0.2498390 1.6507085 -1.2740294 0.06441667 0.09010000 0.079033333 -0.011066667 8.025730e-01 3.593096e-68 FALSE TRUE
ENST00000455113 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding nonsense_mediated_decay 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 3.797055 6.056562 3.9045685 1.1030823 1.4601712 -0.6320259 0.05815833 0.05696667 0.077600000 0.020633333 9.240771e-01 3.593096e-68   FALSE
ENST00000534947 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding protein_coding 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 2.712618 7.670850 0.1702877 1.2300188 0.1702877 -5.4128933 0.03529583 0.07213333 0.003533333 -0.068600000 1.238112e-02 3.593096e-68 FALSE TRUE
ENST00000539735 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding protein_coding 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 8.451743 11.856390 5.5301431 1.9599707 0.4594079 -1.0988860 0.12599167 0.10936667 0.108966667 -0.000400000 1.000000e+00 3.593096e-68 FALSE TRUE
ENST00000541866 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding protein_coding 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 3.396460 0.000000 6.5058497 0.0000000 0.4065115 9.3478095 0.05990000 0.00000000 0.128600000 0.128600000 3.593096e-68 3.593096e-68 FALSE FALSE
ENST00000543155 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding protein_coding 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 31.666156 55.119753 20.5407037 1.2617093 2.3196878 -1.4236433 0.46656667 0.51270000 0.404966667 -0.107733333 1.634147e-01 3.593096e-68 FALSE TRUE
ENST00000626119 ENSG00000111652 HEK293_OSMI2_2hA HEK293_TMG_2hB COPS7A protein_coding protein_coding 67.0829 107.5631 50.63502 3.194888 1.111207 -1.086825 5.190218 7.484196 3.8701306 0.5946322 0.7184888 -0.9496686 0.07856667 0.06950000 0.075933333 0.006433333 9.240129e-01 3.593096e-68 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111652 E001 9.959693 0.0161434503 9.920700e-01 9.991396e-01 12 6724014 6724038 25 + 0.967 0.976 0.035
ENSG00000111652 E002 12.500747 0.0042208616 4.655685e-01 6.052373e-01 12 6724039 6724045 7 + 0.990 1.083 0.338
ENSG00000111652 E003 63.632669 0.0010586241 5.377748e-01 6.692888e-01 12 6724046 6724070 25 + 1.708 1.753 0.151
ENSG00000111652 E004 75.822992 0.0003695817 6.722577e-01 7.782856e-01 12 6724071 6724078 8 + 1.796 1.828 0.108
ENSG00000111652 E005 76.770124 0.0003714624 6.243431e-01 7.406759e-01 12 6724079 6724080 2 + 1.799 1.834 0.118
ENSG00000111652 E006 76.915296 0.0003746693 6.790141e-01 7.833127e-01 12 6724081 6724081 1 + 1.803 1.834 0.106
ENSG00000111652 E007 91.890818 0.0003042948 3.662493e-01 5.105918e-01 12 6724082 6724089 8 + 1.865 1.916 0.171
ENSG00000111652 E008 115.543807 0.0004201149 8.711925e-01 9.212043e-01 12 6724090 6724110 21 + 1.989 2.008 0.063
ENSG00000111652 E009 128.469344 0.0002784491 1.896325e-01 3.132875e-01 12 6724111 6724118 8 + 2.003 2.063 0.201
ENSG00000111652 E010 165.540860 0.0002836251 4.189528e-01 5.622173e-01 12 6724119 6724134 16 + 2.128 2.166 0.128
ENSG00000111652 E011 189.690210 0.0002029554 3.461306e-01 4.902978e-01 12 6724135 6724152 18 + 2.184 2.225 0.135
ENSG00000111652 E012 175.189925 0.0002290503 2.265032e-01 3.582400e-01 12 6724153 6724179 27 + 2.141 2.191 0.167
ENSG00000111652 E013 23.936477 0.0128362827 5.836243e-01 7.076902e-01 12 6724180 6724183 4 + 1.356 1.316 -0.138
ENSG00000111652 E014 46.628086 0.0030945997 2.014519e-01 3.279973e-01 12 6724184 6724250 67 + 1.657 1.590 -0.229
ENSG00000111652 E015 2.663427 0.0056861958 4.074804e-01 5.510493e-01 12 6724251 6724266 16 + 0.613 0.484 -0.596
ENSG00000111652 E016 2.150681 0.0145467650 5.545819e-02 1.187729e-01 12 6724287 6724290 4 + 0.664 0.348 -1.555
ENSG00000111652 E017 3.072807 0.0366043689 2.137002e-01 3.428915e-01 12 6724291 6724292 2 + 0.710 0.511 -0.882
ENSG00000111652 E018 3.072807 0.0366043689 2.137002e-01 3.428915e-01 12 6724293 6724293 1 + 0.710 0.511 -0.882
ENSG00000111652 E019 5.321647 0.0038132411 4.859176e-03 1.553996e-02 12 6724294 6724297 4 + 0.990 0.631 -1.421
ENSG00000111652 E020 10.058564 0.0026608117 5.750797e-04 2.440900e-03 12 6724298 6724305 8 + 1.217 0.867 -1.285
ENSG00000111652 E021 13.404442 0.0345338440 8.375108e-04 3.393227e-03 12 6724306 6724330 25 + 1.367 0.954 -1.477
ENSG00000111652 E022 13.533693 0.0067055774 8.693580e-05 4.607045e-04 12 6724331 6724368 38 + 1.346 0.974 -1.332
ENSG00000111652 E023 12.573802 0.0073889599 3.783268e-05 2.193978e-04 12 6724369 6724378 10 + 1.336 0.934 -1.446
ENSG00000111652 E024 10.358159 0.0168636658 2.171949e-03 7.756039e-03 12 6724379 6724436 58 + 1.231 0.888 -1.250
ENSG00000111652 E025 70.069590 0.0099933670 9.146999e-03 2.664972e-02 12 6724437 6724613 177 + 1.903 1.750 -0.518
ENSG00000111652 E026 705.017285 0.0001628086 2.463074e-02 6.112017e-02 12 6724614 6724818 205 + 2.800 2.779 -0.072
ENSG00000111652 E027 2.691528 0.0057331833 1.806082e-01 3.019412e-01 12 6725648 6725757 110 + 0.664 0.454 -0.970
ENSG00000111652 E028 1.176040 0.0114750376 1.100050e-01 2.055460e-01 12 6725865 6725959 95 + 0.487 0.208 -1.746
ENSG00000111652 E029 6.750470 0.0023892612 2.445981e-05 1.487541e-04 12 6727671 6727800 130 + 1.143 0.652 -1.889
ENSG00000111652 E030 448.011155 0.0001478685 9.519362e-01 9.739101e-01 12 6727926 6728001 76 + 2.576 2.590 0.046
ENSG00000111652 E031 591.254733 0.0003309409 6.857056e-02 1.409971e-01 12 6728223 6728311 89 + 2.722 2.702 -0.065
ENSG00000111652 E032 5.397532 0.0417442435 2.783794e-04 1.291715e-03 12 6729035 6729246 212 + 1.091 0.540 -2.202
ENSG00000111652 E033 446.985791 0.0002479415 9.127407e-01 9.487013e-01 12 6729247 6729300 54 + 2.577 2.587 0.034
ENSG00000111652 E034 441.212854 0.0001562976 4.832807e-04 2.096160e-03 12 6729301 6729360 60 + 2.619 2.566 -0.179
ENSG00000111652 E035 538.353805 0.0004291720 2.031082e-03 7.323329e-03 12 6729361 6729449 89 + 2.699 2.654 -0.152
ENSG00000111652 E036 2.068090 0.0250783553 6.922152e-01 7.935115e-01 12 6729450 6729452 3 + 0.487 0.422 -0.331
ENSG00000111652 E037 512.259848 0.0001763116 5.303872e-01 6.630119e-01 12 6730402 6730507 106 + 2.643 2.644 0.004
ENSG00000111652 E038 2.479660 0.0070639669 3.170738e-01 4.599194e-01 12 6730508 6730509 2 + 0.613 0.454 -0.749
ENSG00000111652 E039 573.229704 0.0001595576 9.583958e-01 9.779179e-01 12 6730669 6730820 152 + 2.686 2.698 0.039
ENSG00000111652 E040 15.279709 0.0103060758 1.295973e-01 2.335888e-01 12 6730821 6730821 1 + 1.013 1.196 0.661
ENSG00000111652 E041 2032.231777 0.0013092073 2.379494e-06 1.820704e-05 12 6731000 6731875 876 + 3.176 3.264 0.294