ENSG00000111647

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000279907 ENSG00000111647 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1BP1L protein_coding protein_coding 5.641253 1.960706 8.857469 0.2040693 0.4316423 2.16981 4.1360241 0.4330719 7.897468 0.08415005 0.5214536 4.157603 0.56544167 0.2202667 0.89173333 0.67146667 2.526756e-08 5.011418e-28 FALSE TRUE
ENST00000356828 ENSG00000111647 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1BP1L protein_coding protein_coding 5.641253 1.960706 8.857469 0.2040693 0.4316423 2.16981 0.1888886 0.2075663 0.305008 0.06582677 0.1692183 0.533933 0.05418333 0.1126667 0.03353333 -0.07913333 1.966744e-01 5.011418e-28 FALSE TRUE
ENST00000545232 ENSG00000111647 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1BP1L protein_coding protein_coding 5.641253 1.960706 8.857469 0.2040693 0.4316423 2.16981 0.4646232 0.6650987 0.000000 0.04835230 0.0000000 -6.077027 0.18186667 0.3414333 0.00000000 -0.34143333 5.011418e-28 5.011418e-28 FALSE TRUE
ENST00000548712 ENSG00000111647 HEK293_OSMI2_2hA HEK293_TMG_2hB UHRF1BP1L protein_coding protein_coding 5.641253 1.960706 8.857469 0.2040693 0.4316423 2.16981 0.3011477 0.6035046 0.000000 0.18808036 0.0000000 -5.939002 0.11603333 0.2961000 0.00000000 -0.29610000 6.650751e-14 5.011418e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111647 E001 1.3756282 0.1411142168 4.105335e-02 9.298034e-02 12 100028455 100028551 97 - 0.206 0.646 2.497
ENSG00000111647 E002 1.9636913 0.0075328397 1.713405e-03 6.323899e-03 12 100028552 100028610 59 - 0.237 0.795 2.850
ENSG00000111647 E003 4.2095245 0.1347013131 8.704968e-03 2.555008e-02 12 100037072 100037142 71 - 0.468 0.992 2.184
ENSG00000111647 E004 2.4055522 0.0060236128 7.527041e-03 2.258291e-02 12 100037143 100037180 38 - 0.320 0.795 2.265
ENSG00000111647 E005 83.0466491 0.0004432837 1.381108e-11 2.812802e-10 12 100037181 100037755 575 - 1.708 2.028 1.080
ENSG00000111647 E006 53.0846260 0.0004290881 7.960638e-04 3.245456e-03 12 100039596 100039789 194 - 1.543 1.755 0.721
ENSG00000111647 E007 36.2851521 0.0006227084 2.387685e-02 5.955209e-02 12 100047530 100047638 109 - 1.389 1.566 0.608
ENSG00000111647 E008 54.9848272 0.0023198183 1.471084e-05 9.405115e-05 12 100047943 100048196 254 - 1.545 1.818 0.926
ENSG00000111647 E009 33.4181604 0.0020134913 1.836485e-01 3.057882e-01 12 100050168 100050264 97 - 1.372 1.487 0.398
ENSG00000111647 E010 23.3779294 0.0120275311 7.924932e-01 8.673272e-01 12 100050265 100050318 54 - 1.236 1.267 0.110
ENSG00000111647 E011 38.0751506 0.0025244409 4.300462e-01 5.726825e-01 12 100051079 100051221 143 - 1.430 1.500 0.240
ENSG00000111647 E012 0.7771569 0.0154541366 6.157632e-01 7.339483e-01 12 100051222 100051874 653 - 0.172 0.273 0.851
ENSG00000111647 E013 42.4451879 0.0005353572 1.598815e-01 2.749528e-01 12 100057571 100057746 176 - 1.468 1.577 0.373
ENSG00000111647 E014 137.1777661 0.0003130889 2.978921e-02 7.155054e-02 12 100058029 100059038 1010 - 1.998 1.911 -0.293
ENSG00000111647 E015 76.7250487 0.0003975258 2.913777e-01 4.322414e-01 12 100059039 100059533 495 - 1.745 1.691 -0.182
ENSG00000111647 E016 36.1096776 0.0006202976 1.779298e-01 2.985383e-01 12 100059850 100060043 194 - 1.434 1.324 -0.381
ENSG00000111647 E017 3.5241564 0.1766337540 1.981865e-04 9.560458e-04 12 100069908 100070169 262 - 0.295 1.108 3.602
ENSG00000111647 E018 16.1044743 0.0010822149 7.973022e-01 8.706688e-01 12 100072672 100072678 7 - 1.085 1.122 0.134
ENSG00000111647 E019 28.7619435 0.0006866329 7.351300e-01 8.259487e-01 12 100072679 100072778 100 - 1.330 1.306 -0.082
ENSG00000111647 E020 19.0563568 0.0009800443 5.132207e-02 1.115078e-01 12 100072779 100072785 7 - 1.185 0.948 -0.862
ENSG00000111647 E021 18.4889031 0.0012584985 1.308367e-01 2.353213e-01 12 100072786 100072813 28 - 1.167 0.989 -0.648
ENSG00000111647 E022 36.5782931 0.0005894149 1.136182e-02 3.203075e-02 12 100083016 100083134 119 - 1.451 1.224 -0.793
ENSG00000111647 E023 27.9639506 0.0008840782 7.565525e-03 2.268430e-02 12 100084476 100084532 57 - 1.344 1.060 -1.007
ENSG00000111647 E024 36.5165148 0.0009330554 4.061825e-02 9.216237e-02 12 100084533 100084658 126 - 1.446 1.267 -0.621
ENSG00000111647 E025 30.0709800 0.0006947250 4.861723e-02 1.067130e-01 12 100086275 100086358 84 - 1.365 1.176 -0.665
ENSG00000111647 E026 40.8692165 0.0005097614 1.465849e-01 2.570470e-01 12 100088915 100089095 181 - 1.487 1.375 -0.386
ENSG00000111647 E027 0.0000000       12 100092722 100092902 181 -      
ENSG00000111647 E028 0.0000000       12 100092903 100092908 6 -      
ENSG00000111647 E029 0.0000000       12 100092909 100092964 56 -      
ENSG00000111647 E030 38.7637155 0.0007026533 8.650780e-04 3.491179e-03 12 100095667 100095837 171 - 1.484 1.176 -1.074
ENSG00000111647 E031 36.9328250 0.0005380584 1.627790e-05 1.030406e-04 12 100097365 100097505 141 - 1.471 1.026 -1.573
ENSG00000111647 E032 41.1030892 0.0005171469 3.140278e-03 1.067804e-02 12 100098352 100098541 190 - 1.502 1.246 -0.890
ENSG00000111647 E033 30.7953066 0.0006469134 3.652280e-01 5.095655e-01 12 100102766 100102857 92 - 1.363 1.287 -0.265
ENSG00000111647 E034 19.3890224 0.0010899816 2.837260e-01 4.238774e-01 12 100103913 100103934 22 - 1.178 1.060 -0.423
ENSG00000111647 E035 16.8038647 0.0013842281 2.612630e-01 3.989022e-01 12 100103935 100103951 17 - 1.122 0.989 -0.486
ENSG00000111647 E036 25.9912956 0.0008151483 3.040249e-01 4.460047e-01 12 100108386 100108548 163 - 1.296 1.200 -0.338
ENSG00000111647 E037 1.3726095 0.0101892420 9.263906e-01 9.576402e-01 12 100128580 100128725 146 - 0.294 0.273 -0.150
ENSG00000111647 E038 25.3604572 0.0007923049 1.547945e-01 2.681345e-01 12 100142592 100142874 283 - 1.291 1.150 -0.500