ENSG00000111639

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229238 ENSG00000111639 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL51 protein_coding protein_coding 280.2722 351.4747 268.2039 55.43117 2.687224 -0.3900781 175.98850 243.59577 155.56585 33.07663 1.5731068 -0.6469302 0.6260042 0.6976000 0.5802333 -0.11736667 0.0003787008 0.0003787008 FALSE FALSE
ENST00000537701 ENSG00000111639 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL51 protein_coding protein_coding 280.2722 351.4747 268.2039 55.43117 2.687224 -0.3900781 43.45753 42.11077 46.20284 10.88735 1.1547213 0.1337620 0.1563708 0.1162333 0.1722667 0.05603333 0.0335734919 0.0003787008 FALSE FALSE
ENST00000543164 ENSG00000111639 HEK293_OSMI2_2hA HEK293_TMG_2hB MRPL51 protein_coding protein_coding 280.2722 351.4747 268.2039 55.43117 2.687224 -0.3900781 43.08804 46.28361 43.26020 8.83839 0.8678827 -0.0974394 0.1554042 0.1304333 0.1613667 0.03093333 0.0196509891 0.0003787008   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111639 E001 27.45470 7.746552e-04 2.679821e-03 9.313253e-03 12 6491886 6492102 217 - 1.551 1.359 -0.661
ENSG00000111639 E002 26.65080 1.518617e-03 6.872400e-01 7.896239e-01 12 6492103 6492146 44 - 1.440 1.420 -0.068
ENSG00000111639 E003 43.45421 8.880029e-03 7.893159e-05 4.228411e-04 12 6492147 6492150 4 - 1.398 1.717 1.089
ENSG00000111639 E004 42.93827 8.430483e-03 3.807861e-05 2.206282e-04 12 6492151 6492151 1 - 1.383 1.715 1.134
ENSG00000111639 E005 1186.53726 4.031862e-04 2.681965e-04 1.250284e-03 12 6492152 6492280 129 - 3.019 3.071 0.170
ENSG00000111639 E006 3069.99543 2.047493e-04 2.876214e-01 4.281304e-01 12 6492281 6492467 187 - 3.460 3.470 0.035
ENSG00000111639 E007 3063.58580 8.901375e-05 1.293618e-01 2.332893e-01 12 6492862 6492972 111 - 3.458 3.472 0.049
ENSG00000111639 E008 12.05279 1.457494e-03 4.740755e-01 6.129364e-01 12 6492973 6493046 74 - 1.135 1.072 -0.226
ENSG00000111639 E009 2667.30513 5.168028e-04 1.738142e-02 4.578054e-02 12 6493058 6493250 193 - 3.388 3.410 0.074
ENSG00000111639 E010 295.02528 2.297414e-03 1.488808e-03 5.600344e-03 12 6493251 6493295 45 - 2.513 2.412 -0.337
ENSG00000111639 E011 429.75202 5.674244e-04 1.007003e-09 1.492634e-08 12 6493459 6493673 215 - 2.691 2.574 -0.390
ENSG00000111639 E012 231.19512 2.599294e-04 8.439912e-10 1.267472e-08 12 6493674 6493716 43 - 2.438 2.298 -0.468
ENSG00000111639 E013 376.64195 1.779292e-03 2.551766e-11 4.975037e-10 12 6493717 6493841 125 - 2.665 2.492 -0.578