ENSG00000111602

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000229201 ENSG00000111602 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMELESS protein_coding protein_coding 68.63298 89.37056 54.24613 4.93219 0.7869661 -0.720175 41.745203 63.036740 30.181339 4.0817690 0.7044814 -1.0622870 0.5942250 0.70526667 0.55643333 -0.14883333 0.0004562524 0.0004562524 FALSE TRUE
ENST00000553532 ENSG00000111602 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMELESS protein_coding protein_coding 68.63298 89.37056 54.24613 4.93219 0.7869661 -0.720175 8.862524 12.841467 6.295184 0.5175498 0.2451331 -1.0273227 0.1248833 0.14446667 0.11623333 -0.02823333 0.2631242963 0.0004562524 FALSE TRUE
ENST00000557589 ENSG00000111602 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMELESS protein_coding retained_intron 68.63298 89.37056 54.24613 4.93219 0.7869661 -0.720175 7.618708 6.976346 5.169107 1.0343400 0.2014108 -0.4318349 0.1138875 0.07926667 0.09523333 0.01596667 0.6725177526 0.0004562524 TRUE TRUE
MSTRG.7463.4 ENSG00000111602 HEK293_OSMI2_2hA HEK293_TMG_2hB TIMELESS protein_coding   68.63298 89.37056 54.24613 4.93219 0.7869661 -0.720175 8.211117 5.206861 10.150883 1.9572377 0.5199632 0.9617719 0.1320167 0.05630000 0.18700000 0.13070000 0.0043096173 0.0004562524 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111602 E001 138.307685 3.808422e-03 6.096334e-01 7.290962e-01 12 56416363 56417118 756 - 2.081 2.113 0.105
ENSG00000111602 E002 30.226108 1.359603e-03 8.623841e-01 9.152733e-01 12 56417119 56417126 8 - 1.452 1.448 -0.012
ENSG00000111602 E003 430.329706 4.029194e-03 8.002756e-10 1.208335e-08 12 56417127 56417308 182 - 2.417 2.655 0.793
ENSG00000111602 E004 1719.524866 2.654321e-03 1.192436e-14 3.878837e-13 12 56417309 56417786 478 - 3.041 3.249 0.691
ENSG00000111602 E005 911.788504 3.410295e-03 6.602825e-06 4.574123e-05 12 56417907 56418008 102 - 2.812 2.961 0.497
ENSG00000111602 E006 844.627373 1.635263e-03 2.939199e-06 2.203666e-05 12 56418134 56418289 156 - 2.801 2.921 0.398
ENSG00000111602 E007 544.927256 1.772605e-04 5.010258e-11 9.312975e-10 12 56418290 56418359 70 - 2.606 2.732 0.421
ENSG00000111602 E008 720.753153 6.365609e-04 5.878901e-10 9.105135e-09 12 56420569 56420687 119 - 2.727 2.853 0.421
ENSG00000111602 E009 8.612335 2.029473e-03 4.507187e-01 5.917743e-01 12 56420688 56420812 125 - 1.004 0.927 -0.287
ENSG00000111602 E010 544.626855 5.946633e-04 1.016490e-07 1.030563e-06 12 56420813 56420881 69 - 2.612 2.731 0.393
ENSG00000111602 E011 900.393740 1.582031e-03 7.146880e-04 2.951336e-03 12 56420963 56421134 172 - 2.854 2.940 0.287
ENSG00000111602 E012 84.164244 1.769677e-02 2.541994e-06 1.933640e-05 12 56421135 56421350 216 - 2.099 1.755 -1.158
ENSG00000111602 E013 795.541567 1.048071e-04 7.020974e-05 3.811182e-04 12 56421351 56421493 143 - 2.816 2.881 0.219
ENSG00000111602 E014 18.181339 1.217056e-03 8.414315e-07 7.103051e-06 12 56421494 56421551 58 - 1.472 1.086 -1.357
ENSG00000111602 E015 30.464049 4.588123e-03 3.011101e-12 6.833303e-11 12 56421552 56421726 175 - 1.730 1.251 -1.649
ENSG00000111602 E016 619.626722 1.260125e-04 5.213844e-04 2.239739e-03 12 56421727 56421809 83 - 2.708 2.773 0.218
ENSG00000111602 E017 16.960617 1.880327e-03 2.411750e-09 3.330357e-08 12 56421810 56421898 89 - 1.492 1.004 -1.723
ENSG00000111602 E018 634.525621 1.487012e-04 4.659634e-01 6.055476e-01 12 56421899 56422016 118 - 2.750 2.771 0.070
ENSG00000111602 E019 540.252837 1.319161e-03 9.644678e-01 9.816152e-01 12 56422106 56422191 86 - 2.687 2.696 0.030
ENSG00000111602 E020 1.989713 8.226709e-03 6.619881e-01 7.703561e-01 12 56422192 56422221 30 - 0.374 0.457 0.452
ENSG00000111602 E021 638.701652 1.387840e-03 1.085607e-01 2.034172e-01 12 56422847 56422992 146 - 2.785 2.758 -0.090
ENSG00000111602 E022 739.823077 8.870274e-05 1.803455e-01 3.016058e-01 12 56423274 56423475 202 - 2.837 2.827 -0.033
ENSG00000111602 E023 345.350812 1.436345e-04 1.059547e-02 3.020010e-02 12 56423584 56423624 41 - 2.454 2.518 0.212
ENSG00000111602 E024 453.949815 1.363430e-04 1.217077e-01 2.223727e-01 12 56423625 56423707 83 - 2.591 2.629 0.126
ENSG00000111602 E025 387.152497 6.889702e-04 1.428696e-01 2.519545e-01 12 56423797 56423894 98 - 2.566 2.542 -0.081
ENSG00000111602 E026 539.898284 1.721862e-03 2.149198e-01 3.443352e-01 12 56424762 56424913 152 - 2.709 2.686 -0.074
ENSG00000111602 E027 561.209679 2.505974e-04 4.690992e-01 6.083989e-01 12 56425015 56425152 138 - 2.712 2.709 -0.011
ENSG00000111602 E028 648.872378 2.470910e-03 4.292709e-02 9.640695e-02 12 56428236 56428405 170 - 2.806 2.758 -0.159
ENSG00000111602 E029 472.007328 2.282082e-03 3.195554e-02 7.577201e-02 12 56428549 56428652 104 - 2.671 2.618 -0.176
ENSG00000111602 E030 650.602037 1.233830e-04 7.008476e-17 3.077021e-15 12 56428883 56429100 218 - 2.853 2.737 -0.387
ENSG00000111602 E031 501.712784 8.679293e-04 5.159972e-13 1.325430e-11 12 56430105 56430281 177 - 2.759 2.614 -0.482
ENSG00000111602 E032 371.128367 1.048776e-03 3.863310e-12 8.605437e-11 12 56430881 56430968 88 - 2.636 2.476 -0.533
ENSG00000111602 E033 494.470747 1.670681e-03 5.739923e-12 1.242330e-10 12 56431471 56431604 134 - 2.764 2.598 -0.552
ENSG00000111602 E034 480.847079 2.613204e-03 5.049512e-08 5.439948e-07 12 56432369 56432521 153 - 2.743 2.593 -0.501
ENSG00000111602 E035 146.546106 3.789800e-03 1.131577e-03 4.409806e-03 12 56432522 56432524 3 - 2.214 2.087 -0.427
ENSG00000111602 E036 367.846829 4.729054e-03 1.107030e-03 4.326873e-03 12 56433026 56433127 102 - 2.604 2.491 -0.378
ENSG00000111602 E037 256.961484 3.888282e-03 1.160297e-04 5.957041e-04 12 56433381 56433443 63 - 2.462 2.327 -0.450
ENSG00000111602 E038 366.851573 3.439451e-03 2.148176e-07 2.046802e-06 12 56433538 56433652 115 - 2.637 2.471 -0.551
ENSG00000111602 E039 426.366357 2.165949e-03 1.441604e-09 2.073867e-08 12 56433773 56433926 154 - 2.699 2.538 -0.538
ENSG00000111602 E040 386.397154 2.765410e-03 3.405082e-08 3.795273e-07 12 56434074 56434231 158 - 2.657 2.494 -0.542
ENSG00000111602 E041 192.732390 3.909722e-03 3.160992e-04 1.445183e-03 12 56449310 56449447 138 - 2.337 2.203 -0.449