ENSG00000111581

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537662 ENSG00000111581 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP107 protein_coding retained_intron 40.24415 8.871649 66.36956 0.5381988 2.165018 2.90184 2.038201 0.1452598 3.913313 0.02582051 0.4004460 4.659316 0.05481667 0.0164 0.05943333 0.04303333 2.701692e-03 4.378019e-12    
ENST00000540453 ENSG00000111581 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP107 protein_coding retained_intron 40.24415 8.871649 66.36956 0.5381988 2.165018 2.90184 2.162464 0.0000000 3.552454 0.00000000 0.3501145 8.476728 0.03572083 0.0000 0.05333333 0.05333333 4.378019e-12 4.378019e-12    
MSTRG.7637.4 ENSG00000111581 HEK293_OSMI2_2hA HEK293_TMG_2hB NUP107 protein_coding   40.24415 8.871649 66.36956 0.5381988 2.165018 2.90184 32.139930 7.6904645 53.605942 0.45378302 2.1945900 2.799645 0.78942500 0.8671 0.80733333 -0.05976667 6.788818e-02 4.378019e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111581 E001 1.3620004 0.0096811646 7.630497e-01 8.465188e-01 12 68686951 68686970 20 + 0.305 0.263 -0.293
ENSG00000111581 E002 4.7211945 0.0034515397 4.045287e-01 5.482395e-01 12 68686971 68686977 7 + 0.660 0.543 -0.515
ENSG00000111581 E003 19.4947679 0.0017100833 1.506664e-02 4.063971e-02 12 68686978 68686991 14 + 1.212 0.969 -0.879
ENSG00000111581 E004 47.6670020 0.0323656481 8.432059e-03 2.486579e-02 12 68686992 68686999 8 + 1.583 1.308 -0.949
ENSG00000111581 E005 65.5874739 0.0152404008 1.484561e-03 5.586716e-03 12 68687000 68687005 6 + 1.717 1.468 -0.848
ENSG00000111581 E006 141.5100180 0.0068273583 2.766736e-05 1.659174e-04 12 68687006 68687073 68 + 2.043 1.830 -0.714
ENSG00000111581 E007 0.0000000       12 68687455 68687461 7 +      
ENSG00000111581 E008 0.1515154 0.0435843367 1.000000e+00   12 68687462 68687591 130 + 0.052 0.000 -8.705
ENSG00000111581 E009 202.9501992 0.0041245671 2.959142e-07 2.741726e-06 12 68688962 68689053 92 + 2.197 1.990 -0.695
ENSG00000111581 E010 213.1804900 0.0002650343 2.398681e-08 2.753244e-07 12 68689533 68689619 87 + 2.214 2.060 -0.513
ENSG00000111581 E011 4.7606112 0.1963110054 3.385175e-01 4.823920e-01 12 68689620 68689910 291 + 0.673 0.432 -1.120
ENSG00000111581 E012 2.3812160 0.0587812274 8.305412e-01 8.937003e-01 12 68690468 68690602 135 + 0.444 0.425 -0.102
ENSG00000111581 E013 2.5359536 0.0061745900 2.548162e-01 3.915974e-01 12 68690603 68690630 28 + 0.483 0.263 -1.293
ENSG00000111581 E014 163.7214195 0.0002054042 8.950875e-06 6.018515e-05 12 68690631 68690670 40 + 2.096 1.966 -0.437
ENSG00000111581 E015 174.6058333 0.0002408603 6.172941e-06 4.305922e-05 12 68690671 68690746 76 + 2.124 1.996 -0.429
ENSG00000111581 E016 200.3241287 0.0002246826 5.298109e-09 6.880859e-08 12 68691968 68692112 145 + 2.188 2.017 -0.571
ENSG00000111581 E017 0.5848434 0.0218274556 6.686290e-01 7.755925e-01 12 68692113 68692169 57 + 0.179 0.000 -10.704
ENSG00000111581 E018 100.1897007 0.0003110903 2.755630e-07 2.569503e-06 12 68696819 68696850 32 + 1.896 1.662 -0.791
ENSG00000111581 E019 135.4662696 0.0008522204 3.899281e-06 2.842712e-05 12 68696851 68696922 72 + 2.020 1.850 -0.572
ENSG00000111581 E020 0.3332198 0.0311863162 2.027002e-01   12 68696923 68696926 4 + 0.052 0.263 2.707
ENSG00000111581 E021 226.9092895 0.0009483072 1.186844e-06 9.702006e-06 12 68700726 68700853 128 + 2.238 2.105 -0.443
ENSG00000111581 E022 174.9536064 0.0054838343 6.372552e-06 4.430153e-05 12 68702736 68702784 49 + 2.134 1.930 -0.684
ENSG00000111581 E023 0.5202097 0.0209337258 3.894367e-01 5.335259e-01 12 68709223 68709237 15 + 0.099 0.263 1.708
ENSG00000111581 E024 184.9087430 0.0002535657 2.212211e-06 1.704335e-05 12 68709238 68709309 72 + 2.150 2.017 -0.442
ENSG00000111581 E025 165.6545321 0.0002467315 6.010985e-05 3.319842e-04 12 68710005 68710093 89 + 2.099 1.989 -0.370
ENSG00000111581 E026 159.3277120 0.0002179155 3.864146e-03 1.276039e-02 12 68713730 68713808 79 + 2.077 2.014 -0.212
ENSG00000111581 E027 32.2630146 0.0194631832 3.554180e-05 2.074462e-04 12 68713809 68714378 570 + 1.436 0.930 -1.809
ENSG00000111581 E028 256.2822312 0.0001887512 1.586867e-04 7.859121e-04 12 68715627 68715740 114 + 2.282 2.215 -0.226
ENSG00000111581 E029 261.5326308 0.0001527161 1.951201e-05 1.213675e-04 12 68719341 68719431 91 + 2.293 2.210 -0.276
ENSG00000111581 E030 244.4678643 0.0001783425 4.530890e-04 1.978936e-03 12 68719578 68719654 77 + 2.260 2.199 -0.205
ENSG00000111581 E031 179.6321659 0.0004098947 3.031630e-04 1.392323e-03 12 68721118 68721135 18 + 2.130 2.041 -0.298
ENSG00000111581 E032 239.5893505 0.0001971046 1.589524e-02 4.250315e-02 12 68721136 68721177 42 + 2.246 2.221 -0.084
ENSG00000111581 E033 301.1710433 0.0001624252 3.523811e-01 4.966487e-01 12 68721841 68721986 146 + 2.338 2.364 0.089
ENSG00000111581 E034 185.8938939 0.0025749211 6.752951e-01 7.806196e-01 12 68722104 68722152 49 + 2.122 2.188 0.223
ENSG00000111581 E035 170.4814632 0.0018816855 8.911313e-01 9.344656e-01 12 68725727 68725796 70 + 2.086 2.141 0.186
ENSG00000111581 E036 229.8879447 0.0017055197 5.332880e-01 6.655018e-01 12 68726499 68726617 119 + 2.221 2.249 0.092
ENSG00000111581 E037 141.1825542 0.0015334491 8.689807e-02 1.704307e-01 12 68727351 68727389 39 + 2.020 1.995 -0.083
ENSG00000111581 E038 248.4011563 0.0010115984 9.965663e-01 1.000000e+00 12 68731110 68731260 151 + 2.250 2.302 0.174
ENSG00000111581 E039 239.9257615 0.0001818966 1.447479e-01 2.544876e-01 12 68731607 68731719 113 + 2.227 2.323 0.323
ENSG00000111581 E040 0.1451727 0.0428199540 1.000000e+00   12 68732573 68732636 64 + 0.052 0.000 -8.705
ENSG00000111581 E041 253.2481438 0.0001786569 5.917593e-03 1.839267e-02 12 68732637 68732739 103 + 2.244 2.376 0.441
ENSG00000111581 E042 0.2903454 0.2927256603 1.000000e+00   12 68732740 68732806 67 + 0.098 0.000 -9.701
ENSG00000111581 E043 313.0213718 0.0001692094 8.656460e-15 2.875575e-13 12 68733452 68733612 161 + 2.310 2.555 0.815
ENSG00000111581 E044 385.6758549 0.0063885676 2.196797e-04 1.048225e-03 12 68734708 68734833 126 + 2.407 2.627 0.732
ENSG00000111581 E045 390.1932666 0.0077122294 5.421661e-08 5.799319e-07 12 68735231 68735344 114 + 2.389 2.701 1.039
ENSG00000111581 E046 2.3950474 0.0061147822 2.925162e-01 4.334853e-01 12 68739724 68740218 495 + 0.464 0.263 -1.200
ENSG00000111581 E047 358.2556875 0.0094582218 4.930404e-09 6.442614e-08 12 68741813 68741980 168 + 2.339 2.697 1.193
ENSG00000111581 E048 192.9516049 0.0157916479 6.439676e-07 5.571691e-06 12 68742355 68742443 89 + 2.058 2.463 1.352
ENSG00000111581 E049 142.7889521 0.0068035492 3.995445e-08 4.394851e-07 12 68742444 68745423 2980 + 1.947 2.294 1.163
ENSG00000111581 E050 14.7291263 0.0633978053 2.155620e-01 3.450897e-01 12 68745424 68745809 386 + 1.018 1.280 0.940