ENSG00000111554

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000303145 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding protein_coding 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.5649490 0.29444389 0.3684723 0.29444389 0.36847234 0.31401148 0.14260833 0.20500000 0.04863333 -0.15636667 0.87360168 0.01392787 FALSE TRUE
ENST00000393543 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding protein_coding 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.4302511 0.22569316 0.6085845 0.09483544 0.02701599 1.39206086 0.09670000 0.13460000 0.08530000 -0.04930000 0.81862625 0.01392787   FALSE
ENST00000430606 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding protein_coding 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.6253418 0.08693621 0.7039814 0.08693621 0.07621908 2.88077885 0.10333333 0.04250000 0.10010000 0.05760000 0.37901837 0.01392787 FALSE TRUE
ENST00000538454 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding retained_intron 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.4483664 0.04203693 0.6896840 0.02218404 0.04867808 3.74909583 0.06040000 0.02410000 0.09650000 0.07240000 0.01392787 0.01392787 FALSE FALSE
ENST00000539972 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding protein_coding 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.2140955 0.15480841 0.1518691 0.15480841 0.15186911 -0.02596213 0.04633750 0.07610000 0.02060000 -0.05550000 0.84827631 0.01392787 FALSE FALSE
ENST00000545964 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding retained_intron 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.9064480 0.18952863 1.5906005 0.18952863 0.10939429 3.00394562 0.12945000 0.09266667 0.22246667 0.12980000 0.27812976 0.01392787   FALSE
ENST00000682720 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding protein_coding 5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.3257084 0.43304110 0.6650602 0.21961113 0.33377113 0.60757571 0.07817083 0.21223333 0.09696667 -0.11526667 0.85394746 0.01392787 FALSE TRUE
MSTRG.7629.7 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding   5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.3776049 0.05151557 0.6536231 0.05151557 0.21041652 3.43134055 0.05904583 0.03586667 0.08940000 0.05353333 0.46138412 0.01392787 FALSE TRUE
MSTRG.7629.8 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding   5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.4829045 0.12844148 0.5923811 0.09621125 0.44332643 2.12140031 0.08490000 0.06286667 0.07993333 0.01706667 1.00000000 0.01392787 FALSE TRUE
MSTRG.7629.9 ENSG00000111554 HEK293_OSMI2_2hA HEK293_TMG_2hB MDM1 protein_coding   5.471601 1.838665 7.135721 0.2012394 0.3472628 1.950596 0.3583690 0.04933961 0.5240858 0.04933961 0.52408582 3.17000424 0.04927083 0.02426667 0.08123333 0.05696667 0.87722681 0.01392787 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000111554 E001 0.1515154 0.0423030912 1.000000e+00   12 68272443 68272532 90 - 0.079 0.000 -8.060
ENSG00000111554 E002 0.0000000       12 68277624 68277759 136 -      
ENSG00000111554 E003 0.0000000       12 68280648 68280755 108 -      
ENSG00000111554 E004 0.5138669 0.0209388594 8.046029e-01 8.756776e-01 12 68294566 68294567 2 - 0.145 0.186 0.425
ENSG00000111554 E005 7.1899321 0.0026066994 1.352110e-06 1.091826e-05 12 68294568 68294814 247 - 0.621 1.187 2.177
ENSG00000111554 E006 5.8438566 0.0038485814 1.138909e-04 5.856439e-04 12 68294815 68294862 48 - 0.600 1.086 1.906
ENSG00000111554 E007 15.9618685 0.0012199989 1.132903e-08 1.382715e-07 12 68294863 68295049 187 - 0.989 1.466 1.691
ENSG00000111554 E008 5.7365650 0.0040143600 7.860014e-03 2.342867e-02 12 68295050 68295060 11 - 0.661 1.003 1.340
ENSG00000111554 E009 10.3738174 0.0017820379 2.713257e-03 9.412706e-03 12 68295061 68295192 132 - 0.911 1.216 1.110
ENSG00000111554 E010 10.4363774 0.0024512513 7.389280e-02 1.497355e-01 12 68295193 68295264 72 - 0.971 1.156 0.673
ENSG00000111554 E011 19.9412502 0.0010102185 3.089529e-01 4.512354e-01 12 68295265 68295366 102 - 1.316 1.230 -0.300
ENSG00000111554 E012 16.7893046 0.0144378168 9.206775e-01 9.539434e-01 12 68296923 68296982 60 - 1.213 1.218 0.016
ENSG00000111554 E013 24.8789053 0.0008398083 3.350711e-01 4.788314e-01 12 68302620 68302802 183 - 1.355 1.425 0.240
ENSG00000111554 E014 15.2705258 0.0014230174 8.806514e-01 9.274480e-01 12 68302803 68302872 70 - 1.174 1.187 0.049
ENSG00000111554 E015 16.8037941 0.0012074958 1.235197e-01 2.249717e-01 12 68313443 68313552 110 - 1.174 1.305 0.463
ENSG00000111554 E016 17.7472177 0.0015761133 4.931709e-01 6.302090e-01 12 68313644 68313753 110 - 1.223 1.281 0.206
ENSG00000111554 E017 14.3327951 0.0012440015 9.445034e-01 9.691961e-01 12 68314948 68315015 68 - 1.150 1.156 0.022
ENSG00000111554 E018 25.1653376 0.0009006728 6.743933e-02 1.390938e-01 12 68315016 68315221 206 - 1.422 1.281 -0.490
ENSG00000111554 E019 13.0717037 0.0018116792 4.024085e-02 9.147636e-02 12 68315222 68315265 44 - 1.174 0.954 -0.800
ENSG00000111554 E020 22.2851777 0.0023868090 1.257562e-01 2.282245e-01 12 68316078 68316253 176 - 1.370 1.243 -0.443
ENSG00000111554 E021 5.1264310 0.0304618138 8.212654e-01 8.873202e-01 12 68316254 68316408 155 - 0.761 0.724 -0.151
ENSG00000111554 E022 3.6850365 0.0051292328 7.266345e-01 8.195923e-01 12 68316581 68316610 30 - 0.621 0.675 0.231
ENSG00000111554 E023 4.0309338 0.0038544915 9.630703e-03 2.785683e-02 12 68320973 68321346 374 - 0.776 0.315 -2.221
ENSG00000111554 E024 8.8393581 0.0075630953 1.606566e-01 2.759825e-01 12 68321347 68321372 26 - 1.014 0.836 -0.673
ENSG00000111554 E025 11.9952022 0.0014986439 5.679881e-02 1.211153e-01 12 68321373 68321446 74 - 1.137 0.927 -0.770
ENSG00000111554 E026 0.7771569 0.0153787590 7.217201e-01 8.160011e-01 12 68321447 68321524 78 - 0.254 0.186 -0.577
ENSG00000111554 E027 7.1708808 0.0025898618 2.365793e-01 3.702264e-01 12 68321525 68321551 27 - 0.922 0.763 -0.616
ENSG00000111554 E028 7.8112735 0.0022209288 2.168099e-02 5.501250e-02 12 68321552 68321573 22 - 0.989 0.675 -1.229
ENSG00000111554 E029 11.3785860 0.0019807025 5.401716e-02 1.162938e-01 12 68321574 68321628 55 - 1.118 0.899 -0.808
ENSG00000111554 E030 14.3617070 0.0014938259 1.512406e-01 2.633657e-01 12 68323073 68323240 168 - 1.191 1.046 -0.519
ENSG00000111554 E031 0.6633060 0.0214235939 9.548032e-01 9.756759e-01 12 68323241 68323398 158 - 0.203 0.186 -0.160
ENSG00000111554 E032 1.3704314 0.0101498210 6.873910e-01 7.897447e-01 12 68325005 68325120 116 - 0.341 0.414 0.421
ENSG00000111554 E033 2.8379352 0.0097687648 4.677773e-01 6.072707e-01 12 68325121 68325171 51 - 0.503 0.624 0.552
ENSG00000111554 E034 3.5557584 0.0118037292 9.851122e-01 9.947102e-01 12 68325172 68325172 1 - 0.621 0.624 0.010
ENSG00000111554 E035 7.7671594 0.0021853285 5.916934e-01 7.144183e-01 12 68325173 68325247 75 - 0.890 0.954 0.242
ENSG00000111554 E036 6.5656346 0.0026229106 8.402557e-01 9.002648e-01 12 68325248 68325440 193 - 0.843 0.869 0.101
ENSG00000111554 E037 11.5652793 0.0197153524 4.513950e-01 5.923515e-01 12 68325441 68325575 135 - 1.046 1.136 0.325
ENSG00000111554 E038 12.1740595 0.0015167634 9.619360e-01 9.800052e-01 12 68325576 68325904 329 - 1.091 1.086 -0.018
ENSG00000111554 E039 20.4479698 0.0131125793 1.924071e-01 3.167991e-01 12 68325905 68326656 752 - 1.340 1.214 -0.441
ENSG00000111554 E040 34.5332178 0.0028733700 2.215030e-01 3.522018e-01 12 68326657 68327021 365 - 1.541 1.458 -0.285
ENSG00000111554 E041 6.5990615 0.0026981864 3.492351e-01 4.934667e-01 12 68327022 68327510 489 - 0.890 0.763 -0.495
ENSG00000111554 E042 0.0000000       12 68330696 68331106 411 -      
ENSG00000111554 E043 14.7190878 0.0202272983 7.730708e-02 1.551687e-01 12 68331107 68331221 115 - 1.217 1.005 -0.767
ENSG00000111554 E044 0.1515154 0.0423030912 1.000000e+00   12 68332001 68332227 227 - 0.079 0.000 -8.055
ENSG00000111554 E045 6.9021795 0.0097060258 1.853336e-01 3.079066e-01 12 68332228 68332381 154 - 0.911 0.722 -0.743